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Results for "

HIF-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Antibiotic (1) Apoptosis (5) Autophagy (2) Bacterial (4) Caspase (1) Cholinesterase (ChE) (1) DNA Methyltransferase (1) Endogenous Metabolite (1) Environmental Pollutants (1) Ferroptosis (1) Fluorescent Dye (3) Fungal (3) HIF/HIF Prolyl-Hydroxylase (37) HSP (1) MOFs (1) Molecular Glues (2) Monocarboxylate Transporter (3) mTOR (1) NF-κB (1) p38 MAPK (1) Proton Pump (1) Ras (2) Reactive Oxygen Species (ROS) (3) Reference Standards (3) SARS-CoV (3) Small Interfering RNA (siRNA) (2) Topoisomerase (1) VEGFR (2) β-catenin (1)
By Research Areas:	Cancer (30) Cardiovascular Disease (4) Infection (4) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (2)
Oligonucleotides:	siRNA drugs (2) siRNAs (2)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Peptides

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15893

DMOG Maximum Cited Publications 76 Publications Verification Dimethyloxallyl GlycINe	HIF/HIF Prolyl-Hydroxylase Autophagy	Cancer
DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in *HIF-1α* stabilisation and accmulation?in vitro and in vivo ^[1]. DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG?acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal . DMOG induces cell autophagy .

HY-15836

BAY 87-2243 25+ Cited Publications	HIF/HIF Prolyl-Hydroxylase Ferroptosis	Cancer
BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.

HY-13671

LW6 55+ Cited Publications HIF-1α INhibitor; LW8	HIF/HIF Prolyl-Hydroxylase Apoptosis	Cancer
LW6 (HIF-1α inhibitor) is a novel *HIF-1* inhibitor with an IC₅₀ value of 4.4 μM, and it is also an inhibitor of MDH2. LW6 decreases *HIF-1α* protein expression without affecting HIF-1β expression.

HY-18777

KC7F2 15+ Cited Publications	HIF/HIF Prolyl-Hydroxylase	Cancer
KC7F2 is a potent hypoxia inducible factor-1 (HIF-1) pathway inhibitor with an IC₅₀ of 20 μM in LN229-HRE-AP cells, and with potential as a cancer therapy agent ^[1].

HY-106101

Echinomycin 10+ Cited Publications QuINomycIN A; NSC-13502	HIF/HIF Prolyl-Hydroxylase Antibiotic Bacterial	Cancer
Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC₅₀ of 29.4 pM ^[1] .

HY-100575

Acriflavine 5+ Cited Publications AcriflavINium chloride 3,6-AcridINediamINe mix	Environmental Pollutants Fluorescent Dye Monocarboxylate Transporter Bacterial Fungal HIF/HIF Prolyl-Hydroxylase SARS-CoV	Infection Cancer
Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent *HIF-1* inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 ^[1] .

HY-N3244

Moracin O 2 Publications Verification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Moracin O is a 2-arylbenzofuran isolated from the Morus alba Linn. . Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects ^[1] .

HY-119264

PRLX-93936	Molecular Glues Ras Apoptosis HIF/HIF Prolyl-Hydroxylase	Cancer
PRLX-93936 is a molecular Glues that binds to and reprograms the TRIM21 ubiquitin ligase to degrade nuclear pore complexes. PRLX-93936 binds to TRIM21, forms a ternary complex with TRIM21 and NUP98, and mediates the ubiquitination and proteasomal degradation of NUP98 and other nuclear pore complex proteins. PRLX-93936 induces the loss of short-lived cytoplasmic mRNA transcripts, triggers cancer cell apoptosis (Apoptosis), and inhibits the activated Ras pathway. PRLX-93936 inhibits *HIF-1* under hypoxic conditions (IC₅₀ = 0.09 μM in cell-based reporter gene assay). PRLX-93936 suppresses tumor growth in mouse models and improves survival rates in mouse models of multiple myeloma. PRLX-93936 is applicable to research related to pancreatic cancer and multiple myeloma ^[1] .

HY-153017

HIF-1 inhibitor-4	HIF/HIF Prolyl-Hydroxylase	Cancer
HIF-1 inhibitor-4 is a *HIF-1* inhibitor (IC₅₀: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level ^[1].

HY-137239

1,4-DPCA ethyl ester 1 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
1,4-DPCA ethyl ester is the ethyl ester of 1,4-DPCA and can inhibit factor inhibiting HIF (FIH) .

HY-P2657

Verucopeptin	HIF/HIF Prolyl-Hydroxylase Proton Pump Endogenous Metabolite	Cancer
Verucopeptin is a potent HIF-1 (IC50=0.22 μM) inhibitor and decreases the expression of HIF-1 target genes and HIF-1α protein levels. Verucopeptin strongly inhibits v-ATPase activity by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D. Verucopeptin exhibits antitumor activity against multidrug resistance (MDR) cancers and can be used for cancer research.

HY-120087

KG-548	MOFs HIF/HIF Prolyl-Hydroxylase	Cancer
KG-548 is an ARNT/TACC3 disruptor and a *HIF-1α* inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as *HIF-β* .

HY-W088075

Acriflavine hydrochloride 5+ Cited Publications AcriflavINium chloride hydrochloride	Fluorescent Dye HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV Monocarboxylate Transporter Fungal	Infection Cancer
Acriflavine (Acriflavinium chloride) hydrochloride is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine hydrochloride is an antiseptic agent. Acriflavine hydrochloride is a potent *HIF-1* inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine hydrochloride inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine hydrochloride is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 ^[1] .

HY-146144

*HIF-IN-1*	HIF/HIF Prolyl-Hydroxylase	Cancer
HIF-IN-1 (Compound 3c) is a hypoxia-inducible factor (HIF)-1 inhibitor. HIF-IN-1 suppresses HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. HIF-IN-1 shows no obvious cytotoxicity ^[1].

HY-100693

SYP-5 2 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
SYP-5 is a novel *HIF-1* inhibitor, suppresses tumor cells invasion and angiogenesis.

HY-124473

Naphthofluorescein NaphthafluoresceIN	HIF/HIF Prolyl-Hydroxylase	Cancer
Naphthofluorescein inhibits the interaction between HIF-1 and Mint3. Naphthofluorescein suppresses Mint3-dependent HIF-1 activity and glycolysis in cancer cells and macrophages without cytotoxicity in vitro and adverse effect in vivo ^[1]. Naphthofluorescein is also a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging .

HY-108868

Mersalyl Salirgan; SalurIN; Salyrgan	HIF/HIF Prolyl-Hydroxylase VEGFR	Metabolic Disease
Mersalyl (Salirgan) is a potent vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) inducer. Mersalyl induces VEGF and ENO1 mRNA expression. Mersalyl shows diuresis effects ^[1] .

HY-P1420

TAT-cyclo-CLLFVY 2 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
TAT-cyclo-CLLFVY is a cyclic peptide inhibitor of *HIF-1* heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY disrupts *HIF-1α/HIF-1β* protein-protein interaction with an IC₅₀ of 1.3 μM ^[1].

HY-119264A

PRLX-93936 dihydrochloride	Molecular Glues Apoptosis Ras HIF/HIF Prolyl-Hydroxylase	Cancer
PRLX-93936 dihydrochloride is a molecular Glues that binds to and reprograms the TRIM21 ubiquitin ligase to degrade nuclear pore complexes. PRLX-93936 dihydrochloride binds to TRIM21, forms a ternary complex with TRIM21 and NUP98, and mediates the ubiquitination and proteasomal degradation of NUP98 and other nuclear pore complex proteins. PRLX-93936 dihydrochloride induces the loss of short-lived cytoplasmic mRNA transcripts, triggers cancer cell apoptosis (Apoptosis), and inhibits the activated Ras pathway. PRLX-93936 dihydrochloride inhibits *HIF-1* under hypoxic conditions (IC₅₀ = 0.09 μM in cell-based reporter gene assay). PRLX-93936 dihydrochloride suppresses tumor growth in mouse models and improves survival rates in mouse models of multiple myeloma. PRLX-93936 dihydrochloride is applicable to research related to pancreatic cancer and multiple myeloma ^[1] .

HY-P10426

cyclo(CLLFVY)	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC₅₀ of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers ^[1].

HY-123422

GSK360A	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
GSK360A is a potent and orally active HIF-PHD inhibitor with IC₅₀ values of 10, 100, and 126 nM for PHD1, PHD2, and PHD3, respectively. GSK360A activates the HIF-1 alpha pathway and protect the failing heart after myocardial infarction (MI) ^[1].

HY-N3243

Moracin P 2 Publications Verification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects ^[1] .

HY-15893R

DMOG (Standard) Dimethyloxallyl GlycINe (Standard)	HIF/HIF Prolyl-Hydroxylase Autophagy Reference Standards	Cancer
DMOG (Standard) is the analytical standard of DMOG. This product is intended for research and analytical applications. DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo ^[1]. DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal . DMOG induces cell autophagy .

HY-P1888

HIF-1 alpha (556-574)	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
HIF-1 alpha (556-574) is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis ^[1].

HY-153493A

PF-04523655 sodium	Small Interfering RNA (siRNA)	Metabolic Disease
PF-04523655 sodium is a siRNA directed against RTP801 gene. RTP801 sodium is an inhibitor of the mammalian target of rampamycin complex 1 (mTORC1) and downstream transcription factor HIF-1.

HY-163512

Anti-inflammatory agent 79	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based *HIF-1* inhibitor (IC₅₀: 0.55 μM), which can effectively block HIF-1 signals and increase HIF- Degradation of 1α. Anti-inflammatory agent 79 inhibits synovial invasion and migration and inhibits angiogenesis. Anti-inflammatory agent 79 also effectively reduced foot swelling and arthritis in a mouse inflammation model, and down-regulated the levels of inflammatory factors and blood vessel proliferation in the body ^[1].

HY-153493

PF-04523655	Small Interfering RNA (siRNA)	Metabolic Disease
PF-04523655 is a siRNA directed against RTP801 gene. RTP801 is an inhibitor of the mammalian target of rampamycin complex 1 (mTORC1) and downstream transcription factor HIF-1.

HY-P1420A

TAT-cyclo-CLLFVY TFA	HIF/HIF Prolyl-Hydroxylase	Cancer
TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor of *HIF-1* heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY TFA disrupts *HIF-1α/HIF-1β* protein-protein interaction with an IC₅₀ of 1.3 μM ^[1].

HY-P1888A

HIF-1 alpha (556-574) TFA	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
HIF-1 alpha (556-574) TFA is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis ^[1].

HY-149260

HIF-1 inhibitor-5	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
HIF-1 inhibitor-5 (Compound 16e) is a potent *HIF-1* inhibitor with an IC₅₀ of 2.38 μM. HIF-1 inhibitor-5 possesses anti-angiogenic potential ^[1].

HY-164259

AJM 290	HIF/HIF Prolyl-Hydroxylase	Cancer
AJM 290 is a *Trx-1* inhibitor. AJM 290 is an inhibitor of the HIF-1α COOH-terminal transactivation domain, and blocks HIF-1 binding to DNA ^[1].

HY-113662

CLB-016	HIF/HIF Prolyl-Hydroxylase	Cancer
CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC₅₀ of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response ^[1].

HY-161427

HSP90-IN-30	HSP HIF/HIF Prolyl-Hydroxylase	Cancer
HSP90-IN-30 (compound 3e) inhibits HSP90 chaperone activity. HSP90-IN-30 inhibits the activity of *HIF-1* transcriptional under hypoxia with an IC₅₀ value of 2.16 μM ^[1].

HY-18259

103D5R	HIF/HIF Prolyl-Hydroxylase	Cancer
103D5R (Compound 15) is an inhibitor for the activation of hypoxia-inducible factor-1 (HIF-1) with an IC₅₀ of 35 µM, through reduction of the HIF-1α protein synthesis. 103D5R inhibits the proliferation of LN229 with IC₅₀ of 26 µM ^[1].

HY-134200A

1-Palmitoyl-2-oleoyl-sn-glycerol, 1-Oleoyl-3-palmitoylglycerol (1:1)	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
1-Palmitoyl-2-oleoyl-sn-glycerol, 1-Oleoyl-3-palmitoylglycerol (1:1) is a 1:1 mixture of 1-Palmitoyl-2-oleoyl-sn-glycerol (HY-134200) and 1-Oleoyl-3-palmitoylglycerol (HY-W583685). 1-Palmitoyl-2-oleoyl-sn-glycerol, 1-Oleoyl-3-palmitoylglycerol (1:1) is the major active component of diacylglycerol (DAG) and a hypoxia-inducible factor (HIF) inducer .

HY-100693R

SYP-5 (Standard)	HIF/HIF Prolyl-Hydroxylase Reference Standards	Cancer
SYP-5 (Standard) is the analytical standard of SYP-5 (HY-100693). This product is intended for research and analytical applications. SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.

HY-181955

MS1129	Apoptosis DNA Methyltransferase HIF/HIF Prolyl-Hydroxylase Caspase	Cancer
MS1129 is a DNMT degrader that induces proteasomal degradation of *DNMT1, DNMT3A* and DNMT3B proteins. MS1129 upregulates TRAIL, DR4 and DR5 proteins, downregulates the decoy receptor DcR2, and activates TRAIL-dependent apoptosis via the HIF-1/2 and Caspase-10 pathways. MS1129 is applicable to the research of VHL-deficient clear cell renal cell carcinoma ^[1].

HY-W585945

Mono N-desmethyl disperse polyester dark blue	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Mono N-Desmethyl Disperse Polyester Dark Blue is a bioreductive agent that is activated under hypoxic conditions. Once inside a cell, it is reduced to its active form, which generates reactive oxygen species that can damage cellular components, including DNA. This damage can lead to cell death, particularly in hypoxic cancer cells that are already under stress. It has also been shown to inhibit the activity of hypoxia-inducible factor 1 (HIF-1) , which is a key regulator of the cellular response to hypoxia.

HY-100575R

Acriflavine (Standard) AcriflavINium chloride 3,6-AcridINediamINe mix (Standard)	Fluorescent Dye Reference Standards HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV Monocarboxylate Transporter Fungal	Infection Cancer
Acriflavine (Standard) is the analytical standard of Acriflavine (HY-100575). This product is intended for research and analytical applications. Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 ^[1] .

HY-W800535

Cryptolepine	NF-κB p38 MAPK mTOR Topoisomerase AMPK Apoptosis Cholinesterase (ChE) HIF/HIF Prolyl-Hydroxylase β-catenin	Infection Metabolic Disease Inflammation/Immunology Cancer
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of *c-Myc, mTOR, NF-κB, HIF-1, MAPK* and an activator of AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection ^[1] .

Cat. No.	Product Name

HY-L045

Oxygen Sensing Compound Library	4,097 compounds
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival. HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation. MCE offers a unique collection of 4,097 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Oxygen Sensing Compound Library

4,097 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 4,097 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Type

HY-100575

Acriflavine 5+ Cited Publications AcriflavINium chloride 3,6-AcridINediamINe mix	Fluorescent Dyes
Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent *HIF-1* inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 ^[1] .

Acriflavine

5+ Cited Publications

AcriflavINium chloride 3,6-AcridINediamINe mix

Fluorescent Dyes

Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 ^[1] .

HY-100575R

Acriflavine (Standard) AcriflavINium chloride 3,6-AcridINediamINe mix (Standard)	Fluorescent Dyes
Acriflavine (Standard) is the analytical standard of Acriflavine (HY-100575). This product is intended for research and analytical applications. Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 ^[1] .

Acriflavine (Standard)

AcriflavINium chloride 3,6-AcridINediamINe mix (Standard)

Fluorescent Dyes

Acriflavine (Standard) is the analytical standard of Acriflavine (HY-100575). This product is intended for research and analytical applications. Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P2657

Verucopeptin	HIF/HIF Prolyl-Hydroxylase Proton Pump Endogenous Metabolite	Cancer
Verucopeptin is a potent HIF-1 (IC50=0.22 μM) inhibitor and decreases the expression of HIF-1 target genes and HIF-1α protein levels. Verucopeptin strongly inhibits v-ATPase activity by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D. Verucopeptin exhibits antitumor activity against multidrug resistance (MDR) cancers and can be used for cancer research.

HY-P1420

TAT-cyclo-CLLFVY 2 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
TAT-cyclo-CLLFVY is a cyclic peptide inhibitor of *HIF-1* heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY disrupts *HIF-1α/HIF-1β* protein-protein interaction with an IC₅₀ of 1.3 μM ^[1].

HY-P10426

cyclo(CLLFVY)	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC₅₀ of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers ^[1].

HY-P1888

HIF-1 alpha (556-574)	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
HIF-1 alpha (556-574) is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis ^[1].

HY-P1420A

TAT-cyclo-CLLFVY TFA	HIF/HIF Prolyl-Hydroxylase	Cancer
TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor of *HIF-1* heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY TFA disrupts *HIF-1α/HIF-1β* protein-protein interaction with an IC₅₀ of 1.3 μM ^[1].

HY-P1888A

HIF-1 alpha (556-574) TFA	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
HIF-1 alpha (556-574) TFA is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis ^[1].

Cat. No.	Product Name		Classification

HY-153493A

PF-04523655 sodium		siRNAs siRNA drugs
PF-04523655 sodium is a siRNA directed against RTP801 gene. RTP801 sodium is an inhibitor of the mammalian target of rampamycin complex 1 (mTORC1) and downstream transcription factor HIF-1.

HY-153493

PF-04523655		siRNAs siRNA drugs
PF-04523655 is a siRNA directed against RTP801 gene. RTP801 is an inhibitor of the mammalian target of rampamycin complex 1 (mTORC1) and downstream transcription factor HIF-1.

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