1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase
  3. TAT-cyclo-CLLFVY

TAT-cyclo-CLLFVY 

Cat. No.: HY-P1420 Purity: 95.06%
Handling Instructions

TAT-cyclo-CLLFVY is a cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY disrupts HIF-1α/HIF-1β protein-protein interaction with an IC50 of 1.3 μM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TAT-cyclo-CLLFVY Chemical Structure

TAT-cyclo-CLLFVY Chemical Structure

CAS No. : 1446322-66-2

Size Price Stock Quantity
1 mg USD 240 In-stock
Estimated Time of Arrival: December 31
5 mg USD 840 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1350 Get quote
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TAT-cyclo-CLLFVY:

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Description

TAT-cyclo-CLLFVY is a cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY disrupts HIF-1α/HIF-1β protein-protein interaction with an IC50 of 1.3 μM[1].

In Vitro

TAT-cyclo-CLLFVY inhibits HIF-1 activity in a mammalian cell luciferase reporter assay[1].
Hypoxia (1% O2) results in a ~12-fold increase in the luciferase signal, which is inhibited in a dose-dependent manner by TAT-cyclo-CLLFVY (IC50 of 19±2 μM)[1].
To assess the cell-specificity of TAT-cyclo-CLLFVY, the experiment is repeated in MCF-7 breast cancer cells with similar results (TAT-cyclo-CLLFVY IC50 of 16±1 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2559.08

Formula

C₁₁₁H₁₈₈N₄₂O₂₄S₂

CAS No.
Sequence Shortening

CGRKKRRQRRRPPQ.cyclo(CLLFVY) (Disulfide bridge:Cys1-Cys1')

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (19.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3908 mL 1.9538 mL 3.9077 mL
5 mM 0.0782 mL 0.3908 mL 0.7815 mL
10 mM 0.0391 mL 0.1954 mL 0.3908 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (0.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (0.98 mM); Clear solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (0.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
TAT-cyclo-CLLFVY
Cat. No.:
HY-P1420
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