1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase
  3. TAT-cyclo-CLLFVY TFA

TAT-cyclo-CLLFVY TFA 

Cat. No.: HY-P1420A
Handling Instructions

TAT-cyclo-CLLFVY TFA is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY TFA blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY TFA inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY TFA also reduces tubularization of hypoxic HUVECs.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TAT-cyclo-CLLFVY TFA Chemical Structure

TAT-cyclo-CLLFVY TFA Chemical Structure

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Description

TAT-cyclo-CLLFVY TFA is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY TFA blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY TFA inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY TFA also reduces tubularization of hypoxic HUVECs.

Molecular Weight

2660.88

Formula

C₁₁₈H₁₇₇F₃N₃₂O₃₅

Sequence

Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln.cyclo[Cys-Leu-Leu-Phe-Val-Tyr] (Disulfide bridge:Cys1-Cys1')

Sequence Shortening

CGRKKRRQRRRPPQ.cyclo(CLLFVY) (Disulfide bridge:Cys1-Cys1')

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TAT-cyclo-CLLFVYHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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TAT-cyclo-CLLFVY TFA
Cat. No.:
HY-P1420A
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