175205-09-1
175205-09-1
Chemical Structure
KG-548
- CAS No.: 175205-09-1
- Formula:C9H4F6N4
- Molecular Weight:282.15
IUPAC Name: 5-(3,5-bis(trifluoromethyl)phenyl)-1H-tetrazole
InChIKey: KKJFZIQEWZVVIV-UHFFFAOYSA-N
SMILES: FC(C1=CC(C(F)(F)F)=CC(C2=NN=NN2)=C1)(F)F
Biological Activity: KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KG-548 | 99.90% | KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β. | ||||||||||||||||||||
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References
- [1]. Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8(3):626-35. [Content Brief]
- [2]. Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27(6):735-742. [Content Brief]
