175205-09-1
175205-09-1
Chemical Structure
KG-548
- CAS No.: 175205-09-1
- Formula:C9H4F6N4
- Molecular Weight:282.15
IUPAC Name: 5-(3,5-bis(trifluoromethyl)phenyl)-1H-tetrazole
InChIKey: KKJFZIQEWZVVIV-UHFFFAOYSA-N
SMILES: FC(C1=CC(C(F)(F)F)=CC(C2=NN=NN2)=C1)(F)F
Biological Activity: KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KG-548 | 99.90% | KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β. | ||||||||||||||||||||
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MTPG | MTPG is a potent mGluR2 and mGluR3 antagonist. MTPG can block the induction of brain ischemic tolerance induced by cerebral ischemic preconditioning. MTPG also significantly attenuates the inhibitory effect of L-CCG-1 on the KCl-evoked dopamine release. | |||||||||||||||||||||
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1,2-Bis(3-(trifluoromethyl)phenyl)diselane | 99.97% | 1,2-Bis(3-(trifluoromethyl)phenyl)diselane is an active compound and can be used for research. | ||||||||||||||||||||
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4,4'-Tfmbpy | 99.68% | 4,4'-Tfmbpy(4,4'-Bis(trifluoromethyl)-2,2'-bipyridine) is a metal-organic framework (MOF). | ||||||||||||||||||||
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5-(Trifluoromethyl)-2-[5-(trifluoromethyl)pyridin-2-yl]pyridine | 99.57% | 5-(Trifluoromethyl)-2-[5-(trifluoromethyl)pyridin-2-yl]pyridine(5,5'-Ditrifluoromethyl-2,2'-bipyridine) is a metal-organic framework (MOF). | ||||||||||||||||||||
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5-(1H-Tetrazol-5-yl)isophthalic acid | 5-(1H-Tetrazol-5-yl)isophthalic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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1,3-Di(1H-tetrazol-5-yl)benzene | 1,3-Di(1H-tetrazol-5-yl)benzene is a metal-organic framework (MOF). | |||||||||||||||||||||
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1,4-Di(1H-tetrazol-5-yl)benzene | 1,4-Di(1H-tetrazol-5-yl)benzene is a metal-organic framework (MOF). | |||||||||||||||||||||
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5,5'-Bis(trifluoromethyl)-3,3'-bipyridine | 5,5'-Bis(trifluoromethyl)-3,3'-bipyridine is a metal-organic framework (MOF). | |||||||||||||||||||||
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4,4'-Diiodo-2,2'-bis(trifluoromethyl)-1,1'-biphenyl | 4,4'-Diiodo-2,2'-bis(trifluoromethyl)-1,1'-biphenyl (2,2'-Bis(trifluoromethyl)-4,4'-diiodobiphenyl) is a metal-organic framework (MOF). | |||||||||||||||||||||
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3-(3-Carboxyphenyl)-5-(trifluoromethyl)benzoic acid | 3-(3-Carboxyphenyl)-5-(trifluoromethyl)benzoic acid (5-(Trifluoromethyl)-[1,1'-biphenyl]-3,3'-dicarboxylic acid) is a metal-organic framework (MOF). | |||||||||||||||||||||
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References
- [1]. Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8(3):626-35. [Content Brief]
- [2]. Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27(6):735-742. [Content Brief]
