3 Results for "

Herbimycin A

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Herbimycin A" in MCE Product Catalog:

Herbimycin A
Herbimycin A
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Cat. No.: HY-108486
CAS No.: 70563-58-5
Purity:  99%
Category:  

Infection Quinones Microorganisms Benzene Quinones Disease Research Fields

Target:  

Antibiotic IGF-1R Insulin Receptor EGFR NF-κB Bcr-Abl Src

Herbimycin A is an antibiotic and protein tyrosine kinase inhibitor. Herbimycin A directly inhibits the autophosphorylation of p210 BCR-ABL with an IC50 of approximately 5 μM, and reduces Src kinase activity. Herbimycin A also induces the degradation of receptor tyrosine kinases such as insulin-like growth factor 1 receptor (IGF-1R), insulin receptor (IR) and epidermal growth factor receptor (EGFR) via the ubiquitin-20S proteasome pathway. Herbimycin A directly modifies NF-κB p50, with the main target site involving Cys62, thereby blocking the DNA binding of p50 and NF-κB-driven gene expression. Herbimycin A can be used in studies related to tyrosine kinase signaling, chronic myeloid leukemia, NF-κB signaling, osteoclast function, apoptosis and cellular stress .
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Herbimycin B
Herbimycin B
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Cat. No.: HY-N15076
CAS No.: 76207-83-5
Category:  

Microorganisms Antibiotics Other Antibiotics

Target:  

Src Antibiotic Bacterial

Herbimycin B is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Herbimycin B has herbicidal effect on most monocotyledons and dicotyledons, inhibits the activity of tobacco Mosaic virus (TMV), HeLa cells and Ehrlich cells .
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Herbimycin C
Herbimycin C
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Cat. No.: HY-126699
CAS No.: 91700-92-4
Synonyms: Antibiotic TAN 420D
Target:  

Bacterial

Research Areas:  

Infection

Herbimycin C is a bacterial metabolite originally isolated from S. hygroscopicus. It is cytotoxic to HeLa and Ehrlich cells (IC50s=7.3 and 1.2 μg/mL, respectively).
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