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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
IRAK4-IN-4
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "IRAK4-IN-4" in MCE Product Catalog:
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1 Cited Publications
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IRAK4-IN-4 (Compound 15) is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, with an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM. IRAK4-IN-4 can be used for research of autoimmune diseases .
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1 Cited Publications
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IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
Cat. No.: HY-175764
CAS No.: 3091132-73-6
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FIP22 is a potent and selective IRAK4 PROTAC degrader (HEK293T cells: DC50 = 3.2 nM; THP-1 cells: DC50 = 10.6 nM). FIP22 induces the ubiquitin-proteasome system by forming an IRAK4-FIP22-CRBN ternary complex (EC50 = 12.63 nM), thereby potently blocking IRAK4-mediated NF-κB and MAPK signaling pathways. FIP22 can be used for the study of atopic dermatitis .
Cat. No.: HY-174470
CAS No.: 3065496-26-3
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IRAK4 ligand-14 is a ligand for IRAK4. IRAK4 ligand-14 can be used for synthesizing PROTACs such as APH02174 (HY-174455) .
Cat. No.: HY-168611
CAS No.: 2434841-55-9
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IRAK4 ligand-18 is a Ligand for Target Protein for PROTAC with antitumor activity. PROTAC IRAK4 ligand-4 can be used to synthesize PROTAC IRAK4 degrader-12 (HY-168586) .
Cat. No.: HY-158760
CAS No.: 3033830-07-5
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PROTAC IRAK4 degrader-11 is an imidazopyridine-based PROTAC IRAK4 degrader that degrades IRAK4 protein with a DC50 of 2.29 nM. PROTAC IRAK4 degrader-11 can be used in the research of IRAK4-related diseases, such as immune-related diseases .
Cat. No.: HY-158758
CAS No.: 3033829-95-4
PROTAC IRAK4 degrader-10 is a IRAK4 PROTAC degrader with a DC50 value of 7.68 nM. PROTAC IRAK4 degrader-10 promotes the ubiquitination and degradation of IRAK4. PROTAC IRAK4 degrader-10 can be used for the research of IRAK4-related diseases .
Cat. No.: HY-162538
CAS No.: 3053823-69-8
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LC-MI-3 is an orally active IRAK4 PROTAC degrader with an IC50 of 57.2 nM and high selectivity among human protein kinases. LC-MI-3 eliminates IRAK4 kinase and scaffolding functions via the cereblon E3 ubiquitin ligase and ubiquitin-proteasome systems. LC-MI-3 inhibits downstream nuclear factor-κB and IRAK4-mediated inflammatory signaling pathways. LC-MI-3 can be used for the research of acute lung injury, sepsis, psoriasis, and inflammatory diseases .
Cat. No.: HY-168586
CAS No.: 2919995-09-6
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PROTAC IRAK4 degrader-12 is an orally active IRAK4 PROTAC degrader with a DC50 of 4.87 nM in K562 IRAK4-HiBiT cells. PROTAC IRAK4 degrader-12 induces protein degradation of IRAK4, IKZF1 and IKZF3. It inhibits the proliferation of diffuse large B-cell lymphoma cells. It suppresses tumor growth in mouse xenograft models of lymphoma cells. PROTAC IRAK4 degrader-12 can be used for the research of B-cell lymphoma and diffuse large B-cell lymphoma .
Cat. No.: HY-139318
CAS No.: 2408878-25-9
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IRAK4 ligand-16 is a IRAK4 ligand and can be used for the synthesis of PROTACs, such as PROTAC IRAK4 degrader-4 (HY-139315) and PROTAC IRAK4 degrader-6 (HY-139317) .
Cat. No.: HY-183800
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JH-l-25-NH2 is an IRAK1/4 inhibitor analog derived from JH-I-25 and serves as the IRAK4-binding moiety for synthesizing VHL-recruiting and CRBN-recruiting IRAK4 PROTAC degraders .
Cat. No.: HY-200864
CAS No.: 2654826-81-8
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E3 ligase Ligand 64-2-(4-hydroxypiperidin-4-yl) acetic acid is an E3 ligase-linker conjugate. E3 ligase Ligand 64-2-(4-hydroxypiperidin-4-yl) acetic acid serves as a synthetic intermediate for the IRAK4-targeting PROTAC APH003 (HY-184915) .
Cat. No.: HY-183799
Research Areas:
GSI526 is a IRAK4 PROTAC degrader (DC50=40.17 nM, Dmax=97%; THP-1) based on the VHL ubiquitin-proteasome system. GSI526 inhibits IRAK4-mediated NF-κB and MAPK inflammatory signaling pathways, and induces IRAK4 degradation in myeloid cells. GSI526 is applicable to inflammation-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
