country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-158758

Copy Link Print Information

PROTAC IRAK4 degrader-10

PROTAC IRAK4 degrader-10 is a IRAK4 PROTAC degrader with a DC₅₀ value of 7.68 nM. PROTAC IRAK4 degrader-10 promotes the ubiquitination and degradation of IRAK4. PROTAC IRAK4 degrader-10 can be used for the research of IRAK4-related diseases.
(Pink: Target protein ligand; Blue: Cereblon ligand (HY-W087383); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3033829-95-4
Formula: C₄₃H₄₅F₃N₈O₆
Molecular Weight:826.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PROTAC IRAK4 degrader-10 Chemical Structure

CAS No.: 3033829-95-4

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC IRAK4 degrader-10 is a IRAK4 PROTAC degrader with a DC₅₀ value of 7.68 nM. PROTAC IRAK4 degrader-10 promotes the ubiquitination and degradation of IRAK4. PROTAC IRAK4 degrader-10 can be used for the research of IRAK4-related diseases^[1]. (Pink: Target protein ligand; Blue: Cereblon ligand (HY-W087383); Black: linker).

IC₅₀ & Target

^[1]

IRAK4

7.68 nM (DC₅₀)

Cereblon

All PROTACs Isoforms :

All IRAK Isoforms :

In Vitro

PROTAC IRAK4 degrader-10 (Compound 10) (0-1000 nM; 24 h) induces IRAK4 degradation in HEK293‑IRAK4‑Hibit cells, with a maximum degradation rate of 95.94% and a DC₅₀ value of 7.68 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3033829-95-4
Molecular Weight 826.86
Formula C₄₃H₄₅F₃N₈O₆
SMILES

O=C(C1=NC(C2C(F)(F)C2)=CC=C1)NC3=CN4C(C(F)=C3C(C)(O)C)=NC(C5CCN(CC6CCN(C7=CC8=C(C(N(C(CC9)C(NC9=O)=O)C8=O)=O)C=C7)CC6)CC5)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Xuejūn, et al. Imidazopyridines as IRAK4 degradants and uses thereof. CN117777126A. China. 2024-03-29.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote