3033829-95-4
3033829-95-4
Chemical Structure
PROTAC IRAK4 degrader-10
- CAS No.: 3033829-95-4
- Formula:C43H45F3N8O6
- Molecular Weight:826.86
InChIKey: WIFFXHPUQAHTBH-UHFFFAOYSA-N
SMILES: O=C(C1=NC(C2C(F)(F)C2)=CC=C1)NC3=CN4C(C(F)=C3C(C)(O)C)=NC(C5CCN(CC6CCN(C7=CC8=C(C(N(C(CC9)C(NC9=O)=O)C8=O)=O)C=C7)CC6)CC5)=C4
Biological Activity: PROTAC IRAK4 degrader-10 (compound 10) is an oral active PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 95.94% and the DC50 of 7.68 nM in HEK293 cells (Sturcture Note:(Blue: Cereblon ligand, Black: linker；Pink: IRAK4 ligand)[1].
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PROTAC IRAK4 degrader-10 | PROTAC IRAK4 degrader-10 (compound 10) is an oral active PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 95.94% and the DC50 of 7.68 nM in HEK293 cells (Sturcture Note:(Blue: Cereblon ligand, Black: linker；Pink: IRAK4 ligand). | |||||||||||||||||||||
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References
Keywords
