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IgG1 Fc silencing

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fc Receptor (FcR) (1) ADC Antibody (3) CCR (1) Claudin (1) Complement System (1) Folate Receptor (FR) (1) PD-1/PD-L1 (1) Radionuclide-Drug Conjugates (RDCs) (1)
By Research Areas:	Cancer (5)

Inhibitors & Agonists

Inhibitory Antibodies

Targets Recommended: Fc Receptor (FcR) Human leukocyte immunoglobulin (Ig)-like receptors (LILR) VISTA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99807

Prolgolimab BCD-100	PD-1/PD-L1	Cancer
Prolgolimab (BCD-100) is a human IgG1 anti-PD-1 monoclonal antibody containing the Fc-silencing 'LALA' mutation. Prolgolimab can be used for the research of advanced melanoma .

HY-P991564

Arcotatug IBI-343 antibody; HB37A6; TAK-921 Antibody	ADC Antibody Claudin	Cancer
Arcotatug (IBI-343 antibody) is a CLDN18.2 targeting humanized monoclonal antibody. Arcotatug can be used for synthesis of ADCs .

HY-P992510

Sofetabart LY-4170156 Antibody; MBK-103 Antibody	ADC Antibody Folate Receptor (FR)	Cancer
Sofetabart (LY-4170156 Antibody) is an Fc-silenced, humanized IgG1 antibody targeting FRα, a composition of antibody drug conjugate (ADC) LY-4170156. Sofetabart can be used for the research of Platinum-resistant ovarian cancer and platinum-sensitive ovarian cancer .

HY-P991940

JBH492 Antibody	ADC Antibody CCR	Cancer
JBH492 Antibody is a humanized, Fc-silenced anti-CCR7 IgG1 antibody. JBH492 Antibody can generate antibody drug conjugate (ADC) (JBH492) with a maytansinoid microtubule DM4 (HY-12454). JBH492 Antibody can be used for the study of lymphoma .

HY-P991922

AKIR001	Fc Receptor (FcR) Complement System Radionuclide-Drug Conjugates (RDCs)	Cancer
AKIR001 is a high-affinity human IgG1 antibody targeting CD44v6. AKIR001 carries LALA-silencing mutations in its FcγR-binding domain to reduce FcγR and C1q interactions, minimizing tissue interactions and limiting CDC and ADCC risks. [ ¹⁷⁷Lu] radiolabeled AKIR001, namely [ ¹⁷⁷Lu]Lu-AKIR001, has anticancer activity against epidermoid carcinoma .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99807

Prolgolimab BCD-100	PD-1/PD-L1	Cancer
Prolgolimab (BCD-100) is a human IgG1 anti-PD-1 monoclonal antibody containing the Fc-silencing 'LALA' mutation. Prolgolimab can be used for the research of advanced melanoma .

HY-P991564

Arcotatug IBI-343 antibody; HB37A6; TAK-921 Antibody	ADC Antibody Claudin	Cancer
Arcotatug (IBI-343 antibody) is a CLDN18.2 targeting humanized monoclonal antibody. Arcotatug can be used for synthesis of ADCs .

HY-P992510

Sofetabart LY-4170156 Antibody; MBK-103 Antibody	ADC Antibody Folate Receptor (FR)	Cancer
Sofetabart (LY-4170156 Antibody) is an Fc-silenced, humanized IgG1 antibody targeting FRα, a composition of antibody drug conjugate (ADC) LY-4170156. Sofetabart can be used for the research of Platinum-resistant ovarian cancer and platinum-sensitive ovarian cancer .

HY-P991940

JBH492 Antibody	ADC Antibody CCR	Cancer
JBH492 Antibody is a humanized, Fc-silenced anti-CCR7 IgG1 antibody. JBH492 Antibody can generate antibody drug conjugate (ADC) (JBH492) with a maytansinoid microtubule DM4 (HY-12454). JBH492 Antibody can be used for the study of lymphoma .

HY-P991922

AKIR001	Fc Receptor (FcR) Complement System Radionuclide-Drug Conjugates (RDCs)	Cancer
AKIR001 is a high-affinity human IgG1 antibody targeting CD44v6. AKIR001 carries LALA-silencing mutations in its FcγR-binding domain to reduce FcγR and C1q interactions, minimizing tissue interactions and limiting CDC and ADCC risks. [ ¹⁷⁷Lu] radiolabeled AKIR001, namely [ ¹⁷⁷Lu]Lu-AKIR001, has anticancer activity against epidermoid carcinoma .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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