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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
JUND
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "JUND" in MCE Product Catalog:
Cat. No.: HY-RS19345
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Jund Mouse Pre-designed siRNA Set A contains three designed siRNAs for Jund gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07060
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JUND Human Pre-designed siRNA Set A contains three designed siRNAs for JUND gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25836
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Jund Rat Pre-designed siRNA Set A contains three designed siRNAs for Jund gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W471288
CAS No.: 30479-81-3
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JPC0661 is a direct and allosteric ΔFOSB inhibitor. JPC0661 inhibits the binding of ΔFOSB/JUND and ΔFOsB to DNA with IC50 values in the micromolar range (9-52 uM), directly inhibits ΔFOSB-mediated transcription with IC50 of 0.82 μM in vitro. JPC0661 significantly reduces ΔFOSB occupancy at genomic AP1 sites in vivo. JPC0661 binds to a novel groove outside the DNA-binding cleft of ΔFOSB and disrupt the formation of the ΔFOSB/JUND-DNA complex. JPC0661 can be used for Alzheimer's disease research .
Cat. No.: HY-182050
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YL0441 is an inhibitor of ΔFOSB/JUND heterodimers and ΔFOSB homomultimers, with IC50 values of 13.7 μM and 12.3 μM, respectively. YL0441 blocks the binding of ΔFOSB to DNA. YL0441 reduces ΔFOSB bound to genomic DNA in the hippocampal tissues of APP mice. YL0441 is applicable to the research of Alzheimer's disease .
Cat. No.: HY-179594
CAS No.: 81682-91-9
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HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
