2. Immunology/Inflammation Cell Cycle/DNA Damage
  3. AP-1 DNA Alkylator/Crosslinker
  4. YL0441

YL0441 is an inhibitor of ΔFOSB/JUND heterodimers and ΔFOSB homomultimers, with IC50 values of 13.7 μM and 12.3 μM, respectively. YL0441 blocks the binding of ΔFOSB to DNA. YL0441 reduces ΔFOSB bound to genomic DNA in the hippocampal tissues of APP mice. YL0441 is applicable to the research of Alzheimer's disease.

For research use only. We do not sell to patients.

YL0441

YL0441 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

YL0441 Related Antibodies

Top Publications Citing Use of Products

View All AP-1 Isoform Specific Products:

View All Isoforms
c-Fos FosB Fra1/FOSL1 Fra2/FOSL2 c-Jun

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

YL0441 is an inhibitor of ΔFOSB/JUND heterodimers and ΔFOSB homomultimers, with IC50 values of 13.7 μM and 12.3 μM, respectively. YL0441 blocks the binding of ΔFOSB to DNA. YL0441 reduces ΔFOSB bound to genomic DNA in the hippocampal tissues of APP mice. YL0441 is applicable to the research of Alzheimer's disease[1].

IC50 & Target[1]

ΔFOSB/JUND

13.7<br/> μM (IC50)

ΔFOSB

12.3 μM (IC50)

In Vitro

YL0441 (0-200 μM; 15 min) disrupts the binding of purified full-length mouse ΔFOSB/JUND heterodimers and ΔFOSB/ΔFOSB homomers to a TAMRA-labeled AP-1 consensus oligonucleotide with IC50 values of 13.7 μM and 12.3 μM, respectively[1].
YL0441 (12.5-50 μM; 72 h) shows no detectable toxicity to Neuro 2A cells at concentrations up to 50 μM after 72 h of incubation[1].
YL0441 (1 μM; up to 60 min) exhibits high metabolic stability in mouse liver microsomes, with a half-life greater than 186.38 min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YL0441 Related Antibodies
In Vivo

YL0441 (50 μM; infused into the
hippocampus; for 3 consecutive days) reduces the binding level of ΔFOSB to genomic DNA in the hippocampus of APP transgenic mice by ~94%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: J20 (2-3 month-old; heterozygous transgenic; male and female; Alzheimer's disease model expressing human amyloid precursor protein with Swedish and Indiana mutations)[1]
Dosage: 50 μM; 18.5 ng per hour
Administration: infused into the
hippocampus; continuous; 3 consecutive days
Result: Reduced total ΔFOSB-bound genomic DNA peaks from 9642 to 540, representing a ~94% reduction in total binding events.
Decreased average peak width of remaining ΔFOSB-bound sites from ~286 bp to ~254 bp.
Reduced ΔFOSB binding to unique target genes by ~94%, with a 95% reduction in promoter-bound genes and 91% reduction in distal intergenic-bound genes.
Eliminated ΔFOSB occupancy across all genomic regions (promoters, exons, introns, distal intergenic regions), with no induction of ΔFOSB binding to novel ectopic sites.
Molecular Weight

385.39

Formula

C19H15NO6S
SMILES

O=C(/C=C/C1=CC=CO1)NC(C=C2S(O)(=O)=O)=CC=C2OC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

YL0441 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YL0441YL 0441YL-0441AP-1DNA Alkylator/CrosslinkerActivator Protein 1mouse liver microsomeshippocampusΔFOSB homomerDNAΔFOSB/JUND heterodimerAP-1 consensus oligonucleotidealzheimer's diseaseAPP miceAP-1-luc HEK293 cellsNeuro 2A cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
YL0441
Cat. No.:
HY-182050
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.