1. Search Result
Search Result
Results for "

LCA

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

4

Biochemical Assay Reagents

1

Peptides

3

Natural
Products

16

Recombinant Proteins

1

Isotope-Labeled Compounds

25

Antibodies

6

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0372
    Licochalcone A
    15+ Cited Publications

    Autophagy Cancer
    Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) .
    Licochalcone A
  • HY-41325

    7,12-Dioxolithocholic acid; 3-Hydroxy-7,12-diketocholanoic acid; 7,12-Diketo-LCA

    Endogenous Metabolite Others
    7,12-Diketolithocholic acid (7,12-Diketo-LCA) is a bile acid, which can be produced in the host-gut microbial co-metabolism of the bile acid pool .
    7,12-Diketolithocholic acid
  • HY-116711

    11-cis Retinaldehyde; 11-cis Vitamin A aldehyde

    Drug Derivative Endogenous Metabolite Neurological Disease
    11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model .
    11-cis-Retinal
  • HY-113238A

    Sulfolithocholic acid disodium; LCAS disodium

    GPR39 ROR Metabolic Disease Inflammation/Immunology
    Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC50 values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn 2+, and 0.88 μM and 0.97 μM in the presence of Zn 2+. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn 2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases .
    Lithocholic acid 3-sulfate disodium
  • HY-NP087

    LCA

    Fluorescent Dye Others
    Lens Culinaris Agglutinin (LCA) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Lens Culinaris Agglutinin (LCA) is a biological material or organic compound that can be used in life science research .
    Lens Culinaris Agglutinin
  • HY-NP0180

    LCA (Biotinylated)

    Fluorescent Dye Others
    Lens Culinaris Agglutinin (LCA) Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Lens Culinaris Agglutinin (LCA) Biotinylated is a biological material or organic compound that can be used in life science research .
    Lens Culinaris Agglutinin (Biotinylated)
  • HY-120458
    LCAHA
    1 Publications Verification

    LCA hydroxyamide

    Deubiquitinase Cancer
    LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a .
    LCAHA
  • HY-177795

    3,6-Diketo-LCA

    Drug Derivative Others
    5β-Cholanic acid-3,6-dione (3,6-Diketo-LCA) is a similar substance to Lithocholic acid (LCA) (HY-B0172). 5β-Cholanic acid-3,6-dione cannot activate the Vitamin D receptor (VDR), and can be used as a negative control for studying the relationship between LCA derivatives and VDR .
    5β-Cholanic acid-3,6-dione
  • HY-143712S1

    3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4

    Isotope-Labeled Compounds Drug Metabolite G protein-coupled Bile Acid Receptor 1 ROR Metabolic Disease Inflammation/Immunology Cancer
    Allolithocholic Acid-d4 (3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4) is deuterium labeled Allolithocholic acid (HY-143712). Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease .
    Allolithocholic Acid-d4
  • HY-N0372R

    Reference Standards Autophagy Cancer
    Licochalcone A (Standard) is the analytical standard of Licochalcone A. This product is intended for research and analytical applications. Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) .
    Licochalcone A (Standard)
  • HY-RS07548

    Small Interfering RNA (siRNA) Others

    LCA5 Human Pre-designed siRNA Set A contains three designed siRNAs for LCA5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    LCA5 Human Pre-designed siRNA Set A
    LCA5 Human Pre-designed siRNA Set A
  • HY-NP0134

    LCA (Fluorescein)

    Fluorescent Dye Others
    Lens Culinaris Agglutinin (LCA) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Lens Culinaris Agglutinin (LCA) Fluorescein is a biological material or organic compound that can be used in life science research .
    Lens Culinaris Agglutinin (Fluorescein)
  • HY-P11614

    Liposome Cancer
    LCA-H10 is a lithocholic acid-histidine decapeptide conjugate, a biocompatible lipid nanoparticle (LNP) additive that reduces ionizable lipid proportions, functions as an endosomal escape inducer, and enhances siRNA encapsulation. LCA-H10 increases hepatic accumulation of LNPs in mice after intravenous injection when incorporated into LiLNP-LH and reduces proinflammatory cytokines (IL-6, TNF, IL-1β) in mouse serum. LCA-H10 can be used for the research of prostate cancer .
    LCA-H10
  • HY-RS24552

    Small Interfering RNA (siRNA) Others

    Ptprc Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptprc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ptprc Rat Pre-designed siRNA Set A
    Ptprc Rat Pre-designed siRNA Set A
  • HY-RS02843

    Small Interfering RNA (siRNA) Others

    CLTA Human Pre-designed siRNA Set A contains three designed siRNAs for CLTA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CLTA Human Pre-designed siRNA Set A
    CLTA Human Pre-designed siRNA Set A
  • HY-RS11434

    Small Interfering RNA (siRNA) Others

    PTPRC Human Pre-designed siRNA Set A contains three designed siRNAs for PTPRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PTPRC Human Pre-designed siRNA Set A
    PTPRC Human Pre-designed siRNA Set A
  • HY-RS05922

    Small Interfering RNA (siRNA) Others

    GUCY2D Human Pre-designed siRNA Set A contains three designed siRNAs for GUCY2D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GUCY2D Human Pre-designed siRNA Set A
    GUCY2D Human Pre-designed siRNA Set A
  • HY-RS18077

    Small Interfering RNA (siRNA) Others

    Ptprc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptprc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ptprc Mouse Pre-designed siRNA Set A
    Ptprc Mouse Pre-designed siRNA Set A

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

 

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

 

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: