63 Results for "

LCA

" in MedChemExpress (MCE) Product Catalog:
Products (63)

63 Results for "LCA" in MCE Product Catalog:

19
19 Publications Verification
Cat. No.: HY-N0372
CAS No.: 58749-22-7
Licochalcone A (LCA), a chalconoid, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-120458
CAS No.: 117094-40-3
Purity:  99.91%
Synonyms: LCA hydroxyamide
Target:  

Deubiquitinase

Research Areas:  

Cancer

LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P80063
Synonyms: CD45, PTPRC, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, L-CA

Host:  

Rabbit

Application:  

WB, IHC-P, FC

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-41325
CAS No.: 517-33-9
Synonyms: 7,12-Dioxolithocholic acid; 3-Hydroxy-7,12-diketocholanoic acid; 7,12-Diketo-LCA
Target:  

Endogenous Metabolite

Research Areas:  

Others

7,12-Diketolithocholic acid (7,12-Diketo-LCA) is a bile acid, which can be produced in the host-gut microbial co-metabolism of the bile acid pool .
loading...
    loading...
Cat. No.: HY-116711
CAS No.: 564-87-4
Synonyms: 11-cis Retinaldehyde; 11-cis Vitamin A aldehyde
11-cis-Retinal (11-cis Retinaldehyde; 11-cis Vitamin A aldehyde), oxidized form of 11-cis-Retinol (HY-W587807), is a naturally occurring visual component. 11-cis-Retinal binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. 11-cis-Retinal plays a crucial role in vision, growth and development. 11-cis-Retinal can restore visual function in moths with visual impairments. 11-cis-Retinal can restore retinal function in an early-age LCA2 retinal degeneration 12 mouse model .
loading...
    loading...
Cat. No.: HY-113238A
CAS No.: 64936-81-8
Purity:  99.93%
Synonyms: Sulfolithocholic acid disodium; LCAS disodium
Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC50 values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn 2+, and 0.88 μM and 0.97 μM in the presence of Zn 2+. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn 2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases .
loading...
    loading...
Cat. No.: HY-NP087
Synonyms: LCA
Lens Culinaris Agglutinin (LCA) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Lens Culinaris Agglutinin (LCA) is a biological material or organic compound that can be used in life science research .
loading...
    loading...
Cat. No.: HY-NP0180
Synonyms: LCA (Biotinylated)
Lens Culinaris Agglutinin (LCA) Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Lens Culinaris Agglutinin (LCA) Biotinylated is a biological material or organic compound that can be used in life science research .
loading...
    loading...
Cat. No.: HY-177795
CAS No.: 6868-73-1
Synonyms: 3,6-Diketo-LCA
Target:  

Drug Derivative

Research Areas:  

Others

5β-Cholanic acid-3,6-dione (3,6-Diketo-LCA) is a similar substance to Lithocholic acid (LCA) (HY-B0172). 5β-Cholanic acid-3,6-dione cannot activate the Vitamin D receptor (VDR), and can be used as a negative control for studying the relationship between LCA derivatives and VDR .
loading...
    loading...
Cat. No.: HY-143712S1
Synonyms: 3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4
Allolithocholic Acid-d4 (3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4) is deuterium labeled Allolithocholic acid (HY-143712). Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease .
loading...
    loading...
Cat. No.: HY-N0372R
CAS No.: 58749-22-7
Licochalcone A (Standard) is the analytical standard of Licochalcone A (HY-N0372). This product is intended for research and analytical applications. Licochalcone A (LCA), a chalconoid, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) .
loading...
    loading...
Cat. No.: HY-RS07548
Research Areas:  

Others

LCA5 Human Pre-designed siRNA Set A contains three designed siRNAs for LCA5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-NP0134
Synonyms: LCA (Fluorescein)
Lens Culinaris Agglutinin (LCA) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Lens Culinaris Agglutinin (LCA) Fluorescein is a biological material or organic compound that can be used in life science research .
loading...
    loading...
Cat. No.: HY-P11614
Target:  

Liposome

Research Areas:  

Cancer

LCA-H10 is a lithocholic acid-histidine decapeptide conjugate, a biocompatible lipid nanoparticle (LNP) additive that reduces ionizable lipid proportions, functions as an endosomal escape inducer, and enhances siRNA encapsulation. LCA-H10 increases hepatic accumulation of LNPs in mice after intravenous injection when incorporated into LiLNP-LH and reduces proinflammatory cytokines (IL-6, TNF, IL-1β) in mouse serum. LCA-H10 can be used for the research of prostate cancer .
loading...
    loading...
Cat. No.: HY-RS24552
Research Areas:  

Others

Ptprc Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptprc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS02843
Research Areas:  

Others

CLTA Human Pre-designed siRNA Set A contains three designed siRNAs for CLTA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS11434
Research Areas:  

Others

PTPRC Human Pre-designed siRNA Set A contains three designed siRNAs for PTPRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS05922
Research Areas:  

Others

GUCY2D Human Pre-designed siRNA Set A contains three designed siRNAs for GUCY2D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-P84013
Synonyms: PTPRC; LCA; LY5; B220; L-CA; T200; CD45; GP180

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, FC, ELISA

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-P84013A
Synonyms: PTPRC; LCA; LY5; B220; L-CA; T200; CD45; GP180

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, FC, ELISA

Reactivity:  

Human, Mouse, Rat

loading...
    loading...