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Cat. No.: HY-P84013A

CD45R Antibody (YA3710)(PBS only)

Name: CD45R Antibody (YA3710)(PBS only)
Brand: MedChemExpress
SKU: HY-P84013A
Availability: PreOrder

(Synonyms: PTPRC; LCA; LY5; B220; L-CA; T200; CD45; GP180)

CD45R Antibody (YA3710) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD45R.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	FC FC: Flow Cytometry	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:500-1:2000	1:200-1:1000	1:200-1:1000	1:200-1:400	1:10000

Description

CD45R Antibody (YA3710) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD45R.

Host Mouse
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 180-240 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 147 kDa

Immunogen

Purified recombinant fragment of human CD45R (AA: extra 378-577) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG

Appearance

Solution
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

CD45R (B220) is the classic surface marker for mouse B lymphocytes and is a splice isoform of the CD45 (Ptprc) gene. CD45R is primarily expressed at various stages of B-cell development and is used to identify B cells, analyze B-cell subsets, and study B-cell development, antibody production, autoimmunity, and tumor immunology.
Subcellular Localization

Cell membrane; Single-pass type I membrane protein; Membrane raft; Synapse
Expression

Tissue_specificity:Isomer 1: Detected in thymocytes. Isomer 2: Detected in thymocytes. Isomer 3: Detected in thymocytes. Isomer 4: Not detected in thymocytes. Isomer 5: Detected in thymocytes. Isomer 6: Not detected in thymocytes. Isomer 7: Detected in thymocytes. Isomer 8: Not detected in thymocytes.
Isoforms & Post-Translational Modification

CD45R has 8 isomers: P08575-3: 147486 Da (predicted); P08575-4: 131130 Da (predicted); P08575-5: 142623 Da (predicted); P08575-6: 142898 Da (predicted); P08575-7: 140582 Da (predicted); P08575-8: 138034 Da (predicted); P08575-9: 135719 Da (predicted); P08575-10: 135993 Da (predicted).
Heavily N- and O-glycosylated
Subunit

Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes
SwissProt ID

P08575
Gene ID

5788 [NCBI]
Synonyms

PTPRC; LCA; LY5; B220; L-CA; T200; CD45; GP180