2 Results for "

LY 3009120

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "LY 3009120" in MCE Product Catalog:

  • Targets Recommended:
14
14 Cited Publications
Cat. No.: HY-12558
CAS No.: 1454682-72-4
Purity:  98.66%
Synonyms: DP-4978
Target:  

Raf Autophagy

Research Areas:  

Cancer

LY3009120 (DP-4978) is a pan RAF inhibitor which inhibits BRAF V600E, BRAF WT and CRAF WT with IC50s of 5.8, 9.1 and 15 nM, respectively.
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Cat. No.: HY-164492
CAS No.: 1455031-68-1
Target:  

Raf

Research Areas:  

Cancer

LSN3074753, an analog of LY3009120 (HY-12558), is a pan-RAF and Raf dimer inhibitor. LSN3074753 demonstrates activity against tumor cells with MAPK pathway activation driven by BRAF monomer or RAF dimers including BRAF- or KRAS-mutant colorectal cancer. LSN3074753 combined with Cetuximab (HY-P9905) shows additive and synergistic effects for colorectal cancer PDX models, particularly those with KRAS or BRAF mutation .
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