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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
MSI-H tumors
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "MSI-H tumors" in MCE Product Catalog:
Cat. No.: HY-183610
CAS No.: 3059172-54-9
Target:
Research Areas:
WRN-IN-26 is an orally active Werner syndrome helicase (WRN) inhibitor with a human Ki value of 58.7 μM and an IC50 value of 0.026 μM. WRN-IN-26 selectively targets the cysteine residues of WRN. WRN-IN-26 induces the expression of p21 protein in MSI-H tumor cells. WRN-IN-26 inhibits the growth of MSI-H tumor cells and exhibits potent in vivo efficacy in MSI-H xenograft tumor models. WRN-IN-26 can be used for the research of microsatellite instability-high (MSI-H) cancers .
Cat. No.: HY-184427
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Research Areas:
WRN-IN-27 is a potent, selective and orally active Werner syndrome RecQ helicase (WRN) inhibitor. WRN-IN-27 inhibits WRN with IC50 values of 20.0 nM and 43.2 nM in the ADP-Glo kinase assay and fluorometric helicase assay, respectively. WRN-IN-27 inhibits MSI-H cell growth selectively (GI50 = 61.8-440 nM), and exhibits antitumor activity in the colon cancer model for MSI-H tumor research .
Cat. No.: HY-189009
CAS No.: 3112500-81-6
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Research Areas:
WC-2 is an ATP-competitive covalent WRN helicase inhibitor with IC50 values of 252 nM and 250 nM. WC-2 binds covalently to Cys727 of WRN helicase and maintains conformational complementarity with this protein. WC-2 induces p21 transcription as part of the DNA damage response, and selectively reduces the viability of MSI-H cancer cells. WC-2 can be used in the research of MSI-H tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
