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Mg

" in MedChemExpress (MCE) Product Catalog:

122

Inhibitors & Agonists

4

Fluorescent Dye

20

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3

Peptides

5

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12

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Products

10

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15

Antibodies

1

Click Chemistry

9

Oligonucleotides

2

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13259
    MG-132
    Maximum Cited Publications
    1998 Publications Verification

    Z-Leu-Leu-Leu-al; Mg132

    		 Proteasome Autophagy Apoptosis Cancer
    MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .
    MG-132
  • HY-114158A
    Pronase E (Activity ≥ 4000 U/mg)
    Maximum Cited Publications
    22 Publications Verification

    Pronase (Activity ≥ 4000 U/Mg)

    		 Others Others
    Pronase E (Activity ≥ 4000 U/mg) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids .
    Pronase E (Activity ≥ 4000 U/mg)
  • HY-15887
    MG 149
    10+ Cited Publications

    Tip60 HAT inhibitor

    		 Histone Acetyltransferase Epigenetic Reader Domain Apoptosis PINK1/Parkin Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG149 inhibits the phosphorylation of Parkin and ubiquitin, thereby suppressing the initiation of PINK1-dependent mitophagy. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease .
    MG 149
  • HY-13259C
    (R)-MG-132
    15+ Cited Publications

    (S,R,S)-(-)-Mg-132; Z-Leu-D-Leu-Leu-al

    		 Proteasome Cancer
    (R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132 .
    (R)-MG-132
  • HY-16961
    Sitravatinib
    5+ Cited Publications

    MgCD516; Mg-516

    		 VEGFR c-Kit FLT3 Discoidin Domain Receptor Trk Receptor Inflammation/Immunology Cancer
    Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively . Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment .
    Sitravatinib
  • HY-P1956A
    Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)

    HSA (Cell culture grade, Endotoxin<0.125 EU/Mg)

    		 NF-κB NO Synthase Cardiovascular Disease Inflammation/Immunology
    Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO −) in the vascular wall, contributing to the reduction of blood pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can be used for in vitro cell culture .
    This product is human serum albumin recombinantly expressed in an Escherichia coli expression system.
    Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)
  • HY-153808B
    Complete Freund's adjuvant (CFA, 1 mg/ml)

    		Toll-like Receptor (TLR) Inflammation/Immunology
    Complete Freund's adjuvant (CFA, 1 mg/ml) is an immunoadjuvant emulsified with antigen that can enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA, 1 mg/ml) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA, 1 mg/ml) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA, 1 mg/ml) stimulates a strong and durable immune response and can be used to induce rheumatoid arthritis in rats, and more .
    Complete Freund's adjuvant (CFA, 1 mg/ml)
  • HY-13259D
    MG-132 (negative control)

    		Proteasome Cancer
    MG-132 (negative control) is the negative control form of MG-132 (HY-13259) .
    MG-132 (negative control)
  • HY-129046A
    RNase A (10mg/mL, DNase free)
    3 Publications Verification

    		 DNA/RNA Synthesis Others
    RNase A (10mg/mL, DNase free) is a ribonuclease used to catalyze RNA degradation without containing DNase. RNase A is often employed in cell cycle assay .
    RNase A (10mg/mL, DNase free)
  • HY-18964
    MG-101
    10+ Cited Publications

    Calpain inhibitor I; Ac-LLnL-CHO; ALLN

    		 Proteasome Apoptosis Cancer
    MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer .
    MG-101
  • HY-108552
    MG-115
    1 Publications Verification

    		 Proteasome Apoptosis Cancer
    MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis .
    MG-115
  • HY-P1645A
    Papain (1.5-10 units/mg)

    		Cathepsin Cardiovascular Disease Inflammation/Immunology
    Papain (1.5-10 units/mg) is a cysteine protease of the peptidase C1 family. Papain (1.5-10 units/mg) enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain (1.5-10 units/mg) can induce pulmonary emphysema. Papain (1.5-10 units/mg) can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema .
    Papain (1.5-10 units/mg)
  • HY-14550
    TP-10
    2 Publications Verification

    		 Phosphodiesterase (PDE) Cardiovascular Disease Neurological Disease
    TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC50s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy .
    TP-10
  • HY-113152
    Hypogeic acid (50mg/ml in ethanol)

    		Endogenous Metabolite Neurological Disease Inflammation/Immunology
    Hypogeic acid is a fatty acid and endogenous metabolite, with a concentration of 50 mg/mL in ethanol. The plasma level of Hypogeic acid is negatively correlated with the prevalence of interstitial lung disease in idiopathic inflammatory myopathy. Hypogeic acid can be used in studies related to idiopathic inflammatory myopathy .
    Hypogeic acid (50mg/ml in ethanol)
  • HY-NP002
    BSA Standard Solution (5 mg/mL)

    		Biochemical Assay Reagents Others
    BSA Standard Solution (5 mg/mL) is a bovine serum albumin solution commonly used as a standard for total serum protein detection. BSA Standard Solution (5 mg/mL) can be used for drawing standard curves and calibrating experiments in total protein assays. BSA Standard Solution (5 mg/mL) is also suitable for various biological experiments, including PCR detection inhibition, antibody desalting, chromatography control, SDS-PAGE electrophoresis, and calibration of UV spectrophotometers .
    BSA Standard Solution (5 mg/mL)
  • HY-130122
    MG-277
    1 Publications Verification

    		 Molecular Glues PROTACs Apoptosis Cancer
    MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, GSPT1, with a DC50 of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC50s of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively. Anticancer activity .
    MG-277
  • HY-139307
    MG-2119

    		Tau Protein Neurological Disease
    MG-2119 is a potent monomeric tau and α-syn aggregation inhibitor. MG-2119 is a potential agent for neurological disorders research .
    MG-2119
  • HY-175324
    MG-HuR2

    		Molecular Glues HuR Cancer
    MG-HuR2 is a molecular glue degrader targeting the oncogenic RNA-binding protein HuR (IC50=0.5 μM). MG-HuR2 is promising for research of HuR-overexpressing malignancies (e.g., breast cancer) .
    MG-HuR2
  • HY-W134005
    Mg(Ⅱ)-EDTA disodium tetrahydrate

    Ethylenediaminetetraacetic acid magnesium disodium tetrahydrate

    		 Phosphatase Others
    Mg(Ⅱ)-EDTA disodium tetrahydrate is a reversible non-covalent activator of fructose diphosphatase (Km=0.9 μM). Mg(Ⅱ)-EDTA disodium tetrahydrate synergistically activates fructose diphosphatase with free Mg 2+, promotes the hydrolysis of fructose-1,6-bisphosphate at pH≤8, and plays a role in enhancing the activity of key enzymes in gluconeogenesis .
    Mg(Ⅱ)-EDTA disodium tetrahydrate
  • HY-153627
    GK13S

    		Deubiquitinase Cancer
    GK13S is a deubiquitinase UCHL1 ligand and inhibitor. GK13S inhibits recombinant and cellular UCHL1. GK13S reduces levels of monoubiquitin in human glioblastoma cells . GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    GK13S
  • HY-108551
    MG-262
    1 Publications Verification

    Z-Leu-Leu-LeuB(OH)2; ZL3B

    		 Proteasome VEGFR Apoptosis Reactive Oxygen Species (ROS) Cardiovascular Disease Inflammation/Immunology Cancer
    MG-262 (Z-Leu-Leu-LeuB(OH)2; ZL3B) is a reversible proteasome inhibitor. MG-262 down-regulates VEGF receptor Flt-1. MG-262 inhibits cell growth and induces apoptosis in malignant cells. MG-262 induces reactive oxygen species (ROS). MG-262 can be used for anti-cancer study .
    MG-262
  • HY-16532
    Zoptarelin doxorubicin

    AEZS-108; AN-152

    		 Peptide-Drug Conjugates (PDCs) GnRH Receptor Cancer
    Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro .
    Zoptarelin doxorubicin
  • HY-175207
    CHI3L1-IN-3

    		Glycosidase Cancer
    CHI3L1-IN-3 is a CHI3L1 inhibitor. CHI3L1-IN-3 binds to CHI3L1 with Kds of 13.76 μM and 13.5 μM in MST and SPR assays, respectively. CHI3L1-IN-3 demonstrates extended plasma half-lives and microsomal stability, along with reduced intrinsic clearance. CHI3L1-IN-3 induces dose-dependent cytotoxicity, reduces spheroid mass and inhibits migration in a 3D multicellular glioblastoma (GBM) spheroid model. CHI3L1-IN-3 can be used for the study of GBM .
    CHI3L1-IN-3
  • HY-135416A
    Streptolysin O (≥1000000 units/mg)
    1 Publications Verification

    		 Endogenous Metabolite Infection
    Streptolysin O (≥1000000 units/mg) is a ≥1000000 units/mg Streptolysin O (HY-135416). Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .
    Streptolysin O (≥1000000 units/mg)
  • HY-N15900
    C11 BODIPY 505/515 MG
    1 Publications Verification

    		 Fluorescent Dye Others
    C11 BODIPY 505/515 MG is a fluorescently labeled glycerolipid (Ex/Em = 495/503 nm).
    C11 BODIPY 505/515 MG
  • HY-P990302
    Anti-Human/Rat/Fish AChR Antibody (Mab35)

    		nAChR Neurological Disease
    Anti-Human/Rat/Fish AChR Antibody (Mab35) is an anti-human/rat/fish AChR IgG1 monoclonal antibody. Anti-Human/Rat/Fish AChR Antibody (Mab35) can attack the AChR of neuromuscular junctions. Anti-Human/Rat/Fish AChR Antibody (Mab35) can be used for the construction of myasthenia gravis models .
    Anti-Human/Rat/Fish AChR Antibody (Mab35)
  • HY-P1645B
    Papain (lyophilized powder, ≥10 units/mg protein)

    		Cathepsin Cardiovascular Disease Inflammation/Immunology
    Papain (lyophilized powder, ≥10 units/mg protein) is a cysteine protease of the peptidase C1 family. Papain (lyophilized powder, ≥10 units/mg protein) enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain (lyophilized powder, ≥10 units/mg protein) can induce pulmonary emphysema. Papain (lyophilized powder, ≥10 units/mg protein) can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema .
    Papain (lyophilized powder, ≥10 units/mg protein)
  • HY-139646
    KMG-104

    		Fluorescent Dye Neurological Disease
    KMG-104 is a cell-impermeant highly selective fluorescent Mg 2+ probe. KMG-104 has been used widely and revealed Mg 2+ mobilization in cytoplasm in various types of cells .
    KMG-104
  • HY-159886
    MG-C-30

    		TNF Receptor Inflammation/Immunology
    MG-C-30 is an orally active agonist for CD27 with an EC50 of 0.84 μM. MG-C-30 activates NK cells and T cell co-stimulatory signals, and enhances immune response. MG-C-30 exhibits antitumor efficacy in mouse EG7-OVA model .
    MG-C-30
  • HY-159884
    MG-T-19

    		Tim3 TNF Receptor IFNAR Cancer
    MG-T-19 is an effective TIM-3 inhibitor that can suppress the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9. MG-T-19 can increase the production of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in peripheral blood mononuclear cells (PBMCs) from healthy donors, and enhance the ability of PBMCs to inhibit the proliferation of Kasumi-1 cells (an acute myelogenous leukemia cell line) .
    MG-T-19
  • HY-107672
    MG624

    Stilonium iodide

    		 nAChR Neurological Disease
    MG624 is a potent and selective neuronal α7 nAChR antagonist with a Ki of 106 nM .
    MG624
  • HY-136476
    Mg(II) protoporphyrin IX

    		Endogenous Metabolite Others
    Mg (II) protoporphyrin IX is a precursor of chlorophyll in Chlorella. Mg (II) protoporphyrin IX acts as a negative effector of nuclear photosynthetic gene expression. Mg (II) protoporphyrin IX can be used to study signal molecules involved in plastid-nucleus communication .
    Mg(II) protoporphyrin IX
  • HY-161101
    MG degrader 1

    		PROTACs IKZF Family Cancer
    MG degrader 1 (Compd E14) is a PROTAC degrader of IKZF3, GSPT1, and GSPT2 with an EC50 value of 1.385 nM in MM.1S cells .
    MG degrader 1
  • HY-159747
    Aluminum hydroxide adjuvant aluminum : 4~6 mg/mL

    		Toll-like Receptor (TLR) Inflammation/Immunology
    Aluminum hydroxide adjuvant (aluminum : 4~6 mg/mL) is a micron level water-based aluminum hydroxide adjuvant. The aluminum content is 4 - 6 mg/ml. It has a strong adsorption capacity for negatively charged antigens, a significant sustained-release effect, no stress response, high safety, and can effectively induce immune responses in the body. It is suitable for various veterinary vaccines, including inactivated vaccines or gene-engineered subunit vaccines for bacterial and viral diseases of livestock and poultry.
    Aluminum hydroxide adjuvant aluminum : 4~6 mg/mL
  • HY-P11315
    MG1 peptide

    		Biochemical Assay Reagents Cardiovascular Disease Neurological Disease
    MG1 peptide is an M1 microglia-targeting peptide with blood-brain barrier permeability. MG1 peptide can be used in studies related to ischemic stroke and cerebral ischemia-reperfusion injury .
    MG1 peptide
  • HY-177725
    MG degrader 2

    		Molecular Glues PI4K Cancer
    MG degrader 2 (Compound CM-2) is a CRBN-dependent molecular glue degrader. MG degrader 2 induces ZFP91, FIZ1 and PI4KB degradation. MG degrader 2 has anti-proliferative activity against MM.1S cells (IC50 = 162 nM). MG degrader 2 can be used for the research of cancer, such as multiple myeloma .
    MG degrader 2
  • HY-16961A
    Sitravatinib malate

    MgCD516 malate; Mg-516 malate

    		 VEGFR c-Kit FLT3 Discoidin Domain Receptor Trk Receptor Inflammation/Immunology Cancer
    Sitravatinib malate (MGCD516 malate) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively . Sitravatinib malate shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment .
    Sitravatinib malate
  • HY-13259G
    MG-132

    Z-Leu-Leu-Leu-al

    		 Proteasome Autophagy Apoptosis Cancer
    MG-132 (GMP) (Z-Leu-Leu-Leu-al (GMP)) is MG-132 (HY-13259) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .
    MG-132
  • HY-151879
    Tubulin inhibitor 30

    		Microtubule/Tubulin Ferroptosis Cancer
    Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis .
    Tubulin inhibitor 30
  • HY-101828
    Guaiapate

    Klamar; Mg 5454

    		 Others Inflammation/Immunology
    Guaiapate is an antitussive agent.
    Guaiapate
  • HY-P991475
    MG-1131

    		Transmembrane Glycoprotein NF-κB IFNAR Cancer
    MG-1131 is a human monoclonal antibody (mAb) targeting TIGIT. MG-1131 activates NF-κB signaling in T cells and enhances NK-mediated tumor killing activity in a PVR-dependent manner. MG-1131 blocks TIGIT to increase IFN-γ secretion. MG-1131 can be used in anti-tumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
    MG-1131
  • HY-126179
    Fenquizone

    Mg-13054

    		 Potassium Channel Cardiovascular Disease Metabolic Disease
    Fenquizone (MG-13054) is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics.​ Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension .
    Fenquizone
  • HY-W134153
    MOF-74(Mg)

    		MOFs Others
    MOF-74(Mg) is a metal-organic framework (MOF).
    MOF-74(Mg)
  • HY-177732
    MG-Lin2

    		Molecular Glues MicroRNA Cancer
    Lin28 degrader MG-Lin2 is a molecular glucose degrading agent that targets the Lin28 protein. Lin28 degrader MG-Lin2 significantly inhibit the migration ability of cancer cells. Lin28 degrader MG-Lin2 has no significant cytotoxicity. Lin28 degrader MG-Lin2 can be used for cancer research .
    MG-Lin2
  • HY-177733
    MG-Lin3

    		Molecular Glues MicroRNA Cancer
    Lin28 degrader MG-Lin3 is a molecular glucose degrading agent that targets the Lin28 protein. Lin28 degrader MG-Lin3 significantly reduces the Renilla luciferase signal at 100 µM. Lin28 degrader MG-Lin3 inhibits the maturation of tumor microRNA let-7. Lin28 degrader MG-Lin3 can be used for cancer research .
    MG-Lin3
  • HY-177731
    MG-Lin1

    		Molecular Glues MicroRNA Cancer
    MG-Lin1 is a molecular glucose degrading agent that targets the Lin28 protein. MG-Lin1 can significantly reduce the mRNA levels of let-7 targeting oncogenes. MG-Lin1 can significantly inhibit the migration ability of cancer cells. MG-Lin1 has no obvious cytotoxicity. MG-Lin1 can be used for cancer research .
    MG-Lin1
  • HY-W105884
    H-Asp-OH.Mg

    		Amino Acid Derivatives Others
    H-Asp-OH.Mg is an aspartic acid derivative .
    H-Asp-OH.Mg
  • HY-177728
    MG degrader 3

    		Molecular Glues E1/E2/E3 Enzyme Cancer
    MG degrader 3 (Compound CM-3) is a molecular glucose degrading agent that targets the CRBN protein. MG degrader 3 has certain anti proliferative activity in MM.1S cells (IC50 = 8.7 nM). MG degrader 3 can be used for cancer research .
    MG degrader 3
  • HY-N15886
    C4 BODIPY 505/515 MG

    		Fluorescent Dye Others
    C4 BODIPY 505/515 MG is a fluorescently labeled glycerolipid (Ex/Em = 495/503 nm).
    C4 BODIPY 505/515 MG
  • HY-131065
    MET kinase-IN-2

    		c-Met/HGFR Cancer
    MET kinase-IN-2 is a potent, selective, orally bioavailable MET kinase inhibitor with an IC50 of 7.4 nM. MET kinase-IN-2 has antitumor activity .
    MET kinase-IN-2

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