3098773-64-6
Chemical Structure
MG-HuR2
- CAS No.: 3098773-64-6
- Formula:C22H20N2O5
- Molecular Weight:392.40
IUPAC Name: ethyl (E)-5-(4-(4-methoxyphenyl)-4-oxobut-2-enamido)-1H-indole-2-carboxylate
InChIKey: YIILUFRCJGVEFZ-ZHACJKMWSA-N
SMILES: CCOC(C1=CC2=CC(NC(/C=C/C(C3=CC=C(C=C3)OC)=O)=O)=CC=C2N1)=O
Biological Activity: MG-HuR2 is a molecular glue degrader targeting HuR (ELAVL1) with a Kd of 0.2018 μM. MG-HuR2 recruits the E3 ubiquitin ligase RNF126 and induces proteasome-dependent degradation of HuR. MG-HuR2 exhibits a unique biphasic degradation profile. MG-HuR2 reduces the expression of HuR and its downstream targets Bcl2/FOXQ1, inhibits breast cancer cell proliferation, enhances cytotoxicity and apoptosis (apoptosis), and suppresses the growth of 3D breast cancer tumor spheres. MG-HuR2 can be used in studies related to breast cancer and HuR-targeted protein degradation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MG-HuR2 | 98.70% | MG-HuR2 is a molecular glue degrader targeting HuR (ELAVL1) with a Kd of 0.2018 μM. MG-HuR2 recruits the E3 ubiquitin ligase RNF126 and induces proteasome-dependent degradation of HuR. MG-HuR2 exhibits a unique biphasic degradation profile. MG-HuR2 reduces the expression of HuR and its downstream targets Bcl2/FOXQ1, inhibits breast cancer cell proliferation, enhances cytotoxicity and apoptosis (apoptosis), and suppresses the growth of 3D breast cancer tumor spheres. MG-HuR2 can be used in studies related to breast cancer and HuR-targeted protein degradation. | ||||||||||||||||||||
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