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Mycobacteria

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112

Inhibitors & Agonists

7

Fluorescent Dye

1

Biochemical Assay Reagents

1

Peptides

32

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Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16566A
    Kanamycin sulfate
    Maximum Cited Publications
    29 Publications Verification

    Kanamycin A sulfate

    		 Bacterial Antibiotic Infection
    Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .
    Kanamycin sulfate
  • HY-B0329
    Isoniazid
    10+ Cited Publications

    INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide

    		 Bacterial Autophagy Mitophagy Antibiotic Infection
    Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .
    Isoniazid
  • HY-16566
    Kanamycin
    Maximum Cited Publications
    29 Publications Verification

    Kanamycin A

    		 Antibiotic Bacterial Infection Inflammation/Immunology
    Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .
    Kanamycin
  • HY-B0509B
    Amikacin disulfate
    25+ Cited Publications

    BAY 41-6551 disulfate

    		 Bacterial Antibiotic Infection Cancer
    Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin disulfate
  • HY-10392
    Sutezolid
    4 Publications Verification

    PNU-100480; U-100480; PF-02341272

    		 Bacterial Antibiotic Infection
    Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .
    Sutezolid
  • HY-107813
    Amikacin sulfate
    25+ Cited Publications

    BAY 41-6551 sulfate

    		 Bacterial Antibiotic Infection Cancer
    Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin sulfate
  • HY-B0901
    Bromperidol
    2 Publications Verification

    R-11333

    		 Dopamine Receptor Bacterial Infection Neurological Disease
    Bromperidol (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol can kill Mycobacteria in a synergistic manner with Spectinomycin .
    Bromperidol
  • HY-Y0607
    4-Nitrobenzoic acid

    		Bacterial Drug Intermediate Infection
    4-Nitrobenzoic acid is a nitroaromatic compound that can be used in the synthesis of other active compounds. 4-Nitrobenzoic acid is also an inhibitor agent, which can be used for the recognition of the Mycobacterium tuberculosis complex and differentiation from non-tuberculous mycobacteria .
    4-Nitrobenzoic acid
  • HY-100725
    BM212
    4 Publications Verification

    		 Bacterial Infection
    BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM .
    BM212
  • HY-B1864A
    Kasugamycin hydrochloride
    1 Publications Verification

    Ksg hydrochloride

    		 Environmental Pollutants Antibiotic Bacterial Infection
    Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .
    Kasugamycin hydrochloride
  • HY-D2919
    DMN-Tre

    		Fluorescent Dye Infection
    DMN-Tre is a conjugate of a solvatochromic fluorescent dye and trehalose. DMN-Tre takes advantage of the substrate promiscuity of the endogenous antigen 85 protein complex in mycobacteria to be metabolically integrated into the hydrophobic mycobacterial membrane. Once entering this hydrophobic environment, the linked DMN dye fluorescence is "turned on", enabling specific labeling . DMN-Tre can be used to reflect bacterial metabolic activity and support physiological studies of Mycobacterium tuberculosis .
    DMN-Tre
  • HY-W506116
    Ostruthin

    Ostruthine

    		 Bacterial DNA/RNA Synthesis Cardiovascular Disease Infection
    Ostruthin is a natural coumarin compound with bacterial and antimycobacterial activities . Ostruthin inhibits the growth of mycobacteria and Staphylococcus aureus. Ostruthin suppresses vascular smooth muscle cell proliferation as well as de novo cellular DNA synthesis. Ostruthin is applicable to research related to mycobacterial infections and cardiovascular and cerebrovascular diseases .
    Ostruthin
  • HY-B1864B
    Kasugamycin hydrochloride hydrate
    1 Publications Verification

    Ksg hydrochloride hydrate

    		 Antibiotic Bacterial Infection
    Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .
    Kasugamycin hydrochloride hydrate
  • HY-B0509
    Amikacin hydrate
    25+ Cited Publications

    BAY 41-6551 hydrate

    		 Bacterial Antibiotic Infection Cancer
    Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin hydrate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin hydrate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin hydrate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin hydrate
  • HY-P4284
    Z-GGF-CMK

    		Proteasome ClpP Bacterial Infection
    Z-GGF-CMK is an Antibacterial agent, an inhibitor of the ClpP1P2 serine protease complex (with an IC50 of 50 μM against intracellular ClpP1P2 protease activity in Mycobacterium bovis BCG), and a selective inhibitor of the mycobacterial Proteasome (with an IC50 of 50 μM against the proteasome in M. bovis BCG). Z-GGF-CMK inhibits the growth of mycobacteria. Z-GGF-CMK exhibits cytotoxic activity against liver cancer cells. Z-GGF-CMK can be used in the research of tuberculosis .
    Z-GGF-CMK
  • HY-D1543
    Pyronin B

    		DNA Stain Infection
    Pyronin B is an organic cationic dye used for the staining of bacteria, mycobacteria and ribonucleic acids. Pyronin B is also used as a small hydrophobic (SH) protein channel inhibitor .
    Pyronin B
  • HY-B0329S
    Isoniazid-d4

    INH-d4; Isonicotinic acid hydrazide-d4; Isonicotinic hydrazide-d4

    		 Bacterial Autophagy Mitophagy Antibiotic Infection
    Isoniazid-d4 is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .
    Isoniazid-d4
  • HY-145301
    Mycobactin-IN-1

    		Bacterial Infection
    Mycobactin-IN-1, a pyrazoline analogue, is a mycobactin biosynthesis inhibitor against mycobacteria. Mycobactin-IN-1 binds to salicyl-AMP ligase (MbtA), a key enzyme in the mycobactin biosynthetic pathway. Mycobactin-IN-1 inhibits whole-cell drug efflux pumps in M. smegmatis. Mycobactin-IN-1 eradicates intracellularly surviving mycobacteria. Mycobactin-IN-1 shows an excellent in vivo pharmacokinetic profile. Mycobactin-IN-1 can be used for the research of tuberculosis .
    Mycobactin-IN-1
  • HY-122394
    Thiolactomycin

    		Antibiotic Bacterial Fatty Acid Synthase (FASN) Infection
    Thiolactomycin is an orally active bacterial type II fatty acid synthase (FAS-II) inhibitor with antibacterial and antimalarial activities. Thiolactomycin specifically targets KasA/KasB in mycobacteria and FabB/FabF in bacteria, thereby inhibiting the biosynthesis of fatty acids and mycolic acids. Thiolactomycin can be used in studies related to tuberculosis, systemic bacterial infections, and experimental pyelonephritis .
    Thiolactomycin
  • HY-12930
    SPR719
    4 Publications Verification

    VXc-486

    		 Topoisomerase Bacterial Infection
    SPR719 (VXc-486) is an orally active gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively. SPR719 is promising for research of lung disease caused by non-tuberculous mycobacteria (NTM) .
    SPR719
  • HY-B0329R
    Isoniazid (Standard)

    INH (Standard); Isonicotinic acid hydrazide (Standard); Isonicotinic hydrazide (Standard)

    		 Reference Standards Bacterial Autophagy Mitophagy Antibiotic Infection
    Isoniazid (Standard) is the analytical standard of Isoniazid. This product is intended for research and analytical applications. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .
    Isoniazid (Standard)
  • HY-148478
    MMV688845

    (R)-GSK1729177A

    		 DNA/RNA Synthesis Infection
    MMV688845 is a nontuberculous mycobacteria (NTM) RNA polymerase inhibitor with bactericidal activity against Mycobacterium abscessus and anti-tuberculosis efficacy .
    MMV688845
  • HY-P2948
    Protein serine/threonine kinase

    Ser/Thr protein kinase

    		 Biochemical Assay Reagents Infection
    Protein serine/threonine kinase is a type of serine/threonine protein kinase. Protein serine/threonine kinases are pleiotropic signaling proteins that can phosphorylate various substrates, thereby initiating branched signaling pathways. Mycobacteria protein serine/threonine kinase plays a crucial role in signal transduction pathways, ultimately determining the growth and metabolic adaptability of mycobacteria .
    Protein serine/threonine kinase
  • HY-121473
    Aklavin

    		Antibiotic Bacterial Fungal Parasite Infection
    Aklavin is a structural analog of Aclacinomycin A (HY-N2306) produced by Streptomyces strain A 1165. Aklavin possesses Z-DNA-inducing and stabilizing activities, along with antibiotic, anti-phage and broad-spectrum antimicrobial activities. Aklavin inhibits the proliferation of various viruses (such as influenza virus and poliovirus) and interferes with their nucleoprotein synthesis, while also exhibiting inhibitory effects on staphylococci, mycobacteria and specific fungi. Aklavin blocks phage-induced bacterial lysis by regulating host-parasite interactions. Aklavin shows specific toxicity to fertilized eggs and mice, and does not alter the splicing of the SMN2 gene .
    Aklavin
  • HY-100048
    Acetylisoniazid

    AcINH

    		 Drug Metabolite Infection
    Acetylisoniazid is a primary Isoniazid (HY-B0329) metabolite mediated by N-acetyltransferase (NAT). Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .
    Acetylisoniazid
  • HY-N1969
    3,3'-Di-O-methylellagic acid

    3,8-Di-O-methylellagic acid

    		 Bacterial Infection
    3,3'-Di-O-methylellagic acid obtained from Euphorbia adenochlora selectively inhibits the formation of acid-fastness in mycobacteria without retardation of their growth. 3,3'-di-O-methylellagic acid as a hepatoprotective compound is apparently due to its antioxidative effect .
    3,3'-Di-O-methylellagic acid
  • HY-155639
    Tyramide alkyne
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    Tyramide alkyne is an alternative labeling substrate that can be coupled to detection or enrichment moieties via a Copper-catalyzed Azide/Alkyne Cycloaddition (CuAAC) “click” reaction. Tyramide alkyne can be used for ascorbate peroxidase 2 (APEX2) labeling .
    Tyramide alkyne
  • HY-A0155
    Viomycin

    		Antibiotic Bacterial Infection
    Viomycin is a potent antibiotic against Mycobacteria. Viomycin rapidly inhibits polypeptide chain elongation when added to purified endogenous Escherichia coli polysomes actively engaged in polypeptide synthesis .
    Viomycin
  • HY-161135A
    (rac)-TBAJ-5307

    		Bacterial Infection
    (rac)-TBAJ-5307 is the racemate of TBAJ-5307 (HY-161135). TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria inhibitor that can target the FO-domain of the engine and preventing rotation and proton-translocation .
    (rac)-TBAJ-5307
  • HY-Z16210
    Nebramycin Ⅴ’

    Nebramine factor 5′; 6′′-O-Carbamoyltobramycin

    		 Antibiotic Bacterial Infection
    Nebramycin V' (Nebramine factor 5′) is a multi-component aminoglycoside antibiotic with a broad-spectrum activity against Gram-positive and Gram-negative bacteria and mycobacteria .
    Nebramycin Ⅴ’
  • HY-144665
    MtTMPK-IN-3

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-3 (compound 25) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 0.12 μM. MtTMPK-IN-3 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-3 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 12.5 μM). MtTMPK-IN-3 can be used for researching tuberculosis .
    MtTMPK-IN-3
  • HY-16566R
    Kanamycin (Standard)

    Kanamycin A (Standard)

    		 Reference Standards Antibiotic Bacterial Infection Inflammation/Immunology
    Kanamycin (Standard) is the analytical standard of Kanamycin. This product is intended for research and analytical applications. Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4].
    Kanamycin (Standard)
  • HY-161135
    TBAJ-5307

    		Bacterial Infection
    TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria inhibitor that can target the FO-domain of the engine and preventing rotation and proton-translocation. TBAJ-5307 inhibits non-tuberculous mycobacteria in vitro and in vivo .
    TBAJ-5307
  • HY-A0155B
    Viomycin sulfate hydrate

    		Antibiotic Bacterial Infection
    Viomycin sulfate hydrate is a potent antibiotic against Mycobacteria. Viomycin sulfate hydrate rapidly inhibits polypeptide chain elongation when added to purified endogenous Escherichia coli polysomes actively engaged in polypeptide synthesis .
    Viomycin sulfate hydrate
  • HY-122289
    Metioprim

    		Dihydrofolate reductase (DHFR) Bacterial Infection
    Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria .
    Metioprim
  • HY-N10069
    Bonducellin

    		Bacterial Infection
    Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L) .
    Bonducellin
  • HY-135285
    Rifamexil

    		Antibiotic Bacterial Infection
    Rifamexil is an antibiotic Rifamycin (HY-B1907A) derivative that is active against Mycobacterium avium complex and other mycobacteria .
    Rifamexil
  • HY-B0901A
    Bromperidol hydrochloride
    2 Publications Verification

    R-11333 hydrochloride

    		 Dopamine Receptor Bacterial Neurological Disease
    Bromperidol (R-11333) hydrochloride possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol hydrochloride can kill Mycobacteria in a synergistic manner with Spectinomycin .
    Bromperidol hydrochloride
  • HY-146702
    MtTMPK-IN-8

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-8 (compound 27) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor. MtTMPK-IN-8 has sub-micromolar activity against mycobacteria (MICs = 0.78~9.4 μM) without significant cytotoxicity. MtTMPK-IN-8 can be used for researching tuberculosis .
    MtTMPK-IN-8
  • HY-146701
    MtTMPK-IN-7

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-7 (compound 26) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC50 value of 47 μM. MtTMPK-IN-7 has sub-micromolar activity against mycobacteria (MICs = 2.3~4.7 μM) without significant cytotoxicity. MtTMPK-IN-7 can be used for researching tuberculosis .
    MtTMPK-IN-7
  • HY-146703
    MtTMPK-IN-9

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-9 (compound 28) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC50 value of 48 μM. MtTMPK-IN-9 has sub-micromolar activity against mycobacteria (MICs = 6.25~9.4 μM) without significant cytotoxicity. MtTMPK-IN-9 can be used for researching tuberculosis .
    MtTMPK-IN-9
  • HY-118481
    H-Pro-Glu-OH

    		Lipase Infection
    H-Pro-Glu-OH is a protein secreted by pathogenic mycobacteria through the Type VII secretion system. H-Pro-Glu-OH targets LipY lipases to the cell Surface via the ESX-5 Pathway .
    H-Pro-Glu-OH
  • HY-120733
    Calpinactam

    FKI-4905

    		 Bacterial Endogenous Metabolite Infection Inflammation/Immunology
    Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .
    Calpinactam
  • HY-N14913
    Adenomycin

    		Antibiotic Bacterial Infection
    Adenomycin is an antibiotic that is effective against a wide range of mycobacteria .
    Adenomycin
  • HY-N14902
    Mimosamycin

    		Antibiotic Bacterial Infection
    Mimosamycin is an antibiotic. Mimosamycin has activity against mycobacteria and streptomyces resistant strains .
    Mimosamycin
  • HY-N14469
    Sakyomicin C

    		Antibiotic Bacterial Infection
    Sakyomicin C is a Benzoquinone antibiotic. Sakyomicin C has activity against Gram-positive bacteria and mycobacteria .
    Sakyomicin C
  • HY-N13995
    Serratamolide

    		Antibiotic Bacterial Fungal Infection
    Serratamolide is a depsipeptide antibiotic. Serratamolide has anti-Gram-positive bacteria, mycobacteria and fungi activity, but the activity is weak .
    Serratamolide
  • HY-N14803
    Nanaomycin B

    		Antibiotic Bacterial Fungal Infection
    Nanaomycin B is an antibiotic. Nanaomycin B has anti-Gram-positive bacteria, mycobacteria, mycoplasma and fungi activity .
    Nanaomycin B
  • HY-118553
    Saframycin D

    		Bacterial Infection
    Saframycin D has the effect of anti-Gram-positive bacteria. Saframycin D also has weak activity against mycobacteria .
    Saframycin D
  • HY-N14541
    Saframycin B

    		Bacterial Infection
    Saframycin B has the effect of anti-Gram-positive bacteria. Saframycin B also has weak activity against mycobacteria .
    Saframycin B

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