54-85-3
54-85-3
Chemical Structure
Isoniazid
Synonym(s): INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide
- CAS No.: 54-85-3
- Formula:C6H7N3O
- Molecular Weight:137.14
IUPAC Name: isonicotinohydrazide
InChIKey: QRXWMOHMRWLFEY-UHFFFAOYSA-N
SMILES: O=C(C1=CC=NC=C1)NN
Biological Activity: Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isoniazid | 99.95% | Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity. | ||||||||||||||||||||
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Isoniazid (Standard) | 99.77% | Isoniazid (Standard) is the analytical standard of Isoniazid. This product is intended for research and analytical applications. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity. | ||||||||||||||||||||
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Isoniazid-d4 | 99.86% | Isoniazid-d4 is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity. | ||||||||||||||||||||
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Acetylisoniazid-d4 | Acetylisoniazid-d4 is the deuterium labeled Acetylisoniazid. | |||||||||||||||||||||
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Nicotinuric acid-d4 | 99.07% | Nicotinuric acid-d4 is the 4-labeled Nicotinuric acid (HY-113353). Nicotinuric acid is an acylglycine and the major catabolite of nicotinic acid (HY-B0143). Its urinary levels correlate with body mass index, blood pressure, blood lipid parameters, and high-sensitivity C-reactive protein. Nicotinuric acid participates in coenzyme-related activities including glycolysis, gluconeogenesis, the citric acid cycle, oxidation, and long-chain fatty acid synthesis in various tissues. Nicotinuric acid is associated with the progression of metabolic syndrome to diabetes and atherosclerotic cardiovascular disease[1] | ||||||||||||||||||||
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N-Methylnicotinamide-d4 | 98.18% | N-Methylnicotinamide-d4 is the deuterium labeled N-Methylnicotinamide (HY-124124). N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway. | ||||||||||||||||||||
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Niacin-d4 | 99.61% | Niacin-d4 (Nicotinic acid-d4) is the deuterium labeled Niacin (HY-B0143). Niacin (Nicotinic acid) is a vitamin and is part of the vitamin B group. | ||||||||||||||||||||
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Nicotinamide-d4 | 99.94% | Nicotinamide-d4 is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1. | ||||||||||||||||||||
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4-Aminobenzohydrazide | 99.21% | 4-Aminobenzohydrazide (p-Aminobenzohydrazide) is an irreversible myeloperoxidase (MPO) inhibitor (IC50=0.3 μM) that induces oxidative stress burst in neutrophils (ROS IC50=43.6 μM). 4-Aminobenzohydrazide has been used in subacute stroke research. | ||||||||||||||||||||
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Methyl nicotinate-d4 | 99.5% | Methyl nicotinate-d4 is the deuterium labeled Methyl nicotinate. Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. | ||||||||||||||||||||
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Isonicotinic acid | 99.96% | Isonicotinic acid is a pyridine carboxylic acid compound and also a metabolite of Isoniazid (HY-B0329). Derivatives of Isonicotinic acid exhibit antiviral activity against influenza viruses. | ||||||||||||||||||||
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Isonicotinic acid-d4 | 98.12% | Isonicotinic acid-d4 is the deuterium labeled Isonicotinic acid (HY-I0736). Isonicotinic acid is a pyridine carboxylic acid compound and also a metabolite of Isoniazid (HY-B0329). Derivatives of Isonicotinic acid exhibit antiviral activity against influenza viruses. | ||||||||||||||||||||
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2-Pyridinecarbohydrazide | 99.8% | 2-Pyridinecarbohydrazide is a versatile heterocyclic building block widely used in medicinal chemistry and coordination chemistry, and it finds extensive applications in various synthetic fields. 2-Pyridinecarbohydrazide reacts with the reducing end of carbohydrates to enhance mass spectrometry ionization efficiency, enabling isomer-specific identification of monosaccharides, disaccharides, ketoses/aldoses, and quantitative mass spectrometry imaging of biological tissues. | ||||||||||||||||||||
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4-Hydroxybenzohydrazide (Standard) | ≥98% | 4-Hydroxybenzohydrazide (Standard) is the analytical standard of 4-Hydroxybenzohydrazide. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Nicotinohydrazide | 99.35% | Nicotinohydrazide (Nicotinic acid hydrazide) is a precursor used for synthesizing hydrazone derivatives with antibacterial and antifungal activities. Nicotinohydrazide can be used in studies of bacterial and fungal infections. | ||||||||||||||||||||
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Isonicotinamide | 98.0% | Isonicotinamide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Isonicotinamide-d4 | 99.91% | Isonicotinamide-d4 is the deuterium labeled Isonicotinamide. | ||||||||||||||||||||
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Benzohydrazide (Standard) | 98.67% | Benzohydrazide (Standard) is the analytical standard of Benzohydrazide. This product is intended for research and analytical applications. | ||||||||||||||||||||
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2-Chloroisonicotinohydrazide | 2-Chloroisonicotinohydrazide (2-Chloro-isonicotinic acid hydrazide) (Compound 13a) is an Antibacterial agent. 2-Chloroisonicotinohydrazide exhibits antibacterial activity against Mycobacterium tuberculosis strain H37Rv, with a MIC50 of 392.0 μM. 2-Chloroisonicotinohydrazide can be used in the research of tuberculosis. | |||||||||||||||||||||
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3-Pyridine-2,4,5,6-d4 -carboxylic acid, ethyl ester | 3-Pyridine-2,4,5,6-d4 -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-carboxylic acid, ethyl ester. | |||||||||||||||||||||
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3-Aminoisonicotinohydrazide | 3-Aminoisonicotinohydrazide is an anti-bacterial agent. 3-Aminoisonicotinohydrazide exhibits inhibitory activity against Mycobacterium tuberculosis. 3-Aminoisonicotinohydrazide can be used in antibacterial research. | |||||||||||||||||||||
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4-Hydroxybenzhydrazide-d4 | 4-Hydroxybenzhydrazide-d4 is the deuterium labeled 4-Hydroxybenzohydrazide (HY-W012579). | |||||||||||||||||||||
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4-Acetylpyridine | 99.98% | 4-Acetylpyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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References
- [1]. Suarez, J., et al., An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG). J Biol Chem, 2009. 284(11): p. 7017-29. [Content Brief]
- [2]. Timmins, G.S., et al., Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother, 2004. 48(8): p. 3006-9. [Content Brief]
- [3]. Singh, R., et al., PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science, 2008. 322(5906): p. 1392-5. [Content Brief]
- [4]. Ahmad, Z., et al., Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig. J Infect Dis, 2009. 200(7): p. 1136-43. [Content Brief]
