2177287-88-4
Chemical Structure
DMN-Tre
- CAS No.: 2177287-88-4
- Formula:C26H32N2O12
- Molecular Weight:564.54
InChIKey: LSTRCDZWOCBLDC-OEZPJXQZSA-N
SMILES: O=C1C2=CC=C(N(C)C)C3=C2C(C(N1C[C@H]4O[C@@H]([C@@H]([C@H]([C@@H]4O)O)O)O[C@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)=O)=CC=C3
Biological Activity: DMN-Tre is a conjugate of a solvatochromic fluorescent dye and trehalose. DMN-Tre takes advantage of the substrate promiscuity of the endogenous antigen 85 protein complex in mycobacteria to be metabolically integrated into the hydrophobic mycobacterial membrane. Once entering this hydrophobic environment, the linked DMN dye fluorescence is "turned on", enabling specific labeling. DMN-Tre can be used to reflect bacterial metabolic activity and support physiological studies of Mycobacterium tuberculosis[1][2].
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DMN-Tre | 98.87% | DMN-Tre is a conjugate of a solvatochromic fluorescent dye and trehalose. DMN-Tre takes advantage of the substrate promiscuity of the endogenous antigen 85 protein complex in mycobacteria to be metabolically integrated into the hydrophobic mycobacterial membrane. Once entering this hydrophobic environment, the linked DMN dye fluorescence is "turned on", enabling specific labeling. DMN-Tre can be used to reflect bacterial metabolic activity and support physiological studies of Mycobacterium tuberculosis. | ||||||||||||||||||||
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- [1]. Sahile HA, et al. DMN-Tre Labeling for Detection and High-Content Screening of Compounds against Intracellular Mycobacteria. ACS Omega. 2020;5(7):3661-3669. Published 2020 Feb 14. [Content Brief]
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[2]. Kamariza M, et al. Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe. Science translational medicine. 2018 Feb 28;10(430):eaam6310.
Keywords
