2765 Results for "

NH2

" in MedChemExpress (MCE) Product Catalog:

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145

Caerulein

145 Publications Verification

Cat. No.: HY-A0190

CAS No.: 17650-98-5

Synonyms: Ceruletide; Cerulein; FI-6934

Category:

Cardiovascular Disease Alkaloids Animals Disease Research Fields Endocrinology Indole Alkaloids

Target:

Cholecystokinin Receptor

Caerulein is a decapeptide and a potent cholecystokinin receptor agonist. Caerulein is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts .

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126

GsMTx4 TFA

126 Cited Publications

Cat. No.: HY-P1410A

Target:

TRP Channel Piezo Channel

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology ^[2] .

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126

GsMTx4

126 Cited Publications

Cat. No.: HY-P1410

CAS No.: 1209500-46-8

Target:

TRP Channel Piezo Channel

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology ^[2] .

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Exendin-4

70 Cited Publications

Cat. No.: HY-13443

CAS No.: 141758-74-9

Purity: 99.95%

Synonyms: Exenatide

Target:

GCGR

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC₅₀ of 3.22 nM.

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Exendin-4 acetate

70 Cited Publications

Cat. No.: HY-13443A

CAS No.: 914454-01-6

Purity: 99.91%

Synonyms: Exenatide acetate

Target:

GCGR

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Exendin-4 acetate (Exenatide acetate), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC₅₀ of 3.22 nM.

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Exendin(9-39) amide

45 Cited Publications

Cat. No.: HY-P0264

CAS No.: 133514-43-9

Synonyms: Avexitide

Target:

GLP Receptor

Research Areas:

Metabolic Disease

Exendin(9-39) amide (Avexitide) is a glucagon-like peptide-1 (GLP-1) antagonist that competes with endogenous GLP-1 for binding to GLP-1 receptors, thereby antagonizing the effects of excess GLP-1 secretion. Exendin(9-39) amide can be used to study postoperative hypoglycemia (PBH) .

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Exendin(9-39) amide acetate

45 Cited Publications

Cat. No.: HY-P0264A

CAS No.: 2051593-46-3

Synonyms: Avexitide acetate

Target:

GLP Receptor

Research Areas:

Metabolic Disease

Exendin(9-39) amide (Avexitide) acetate is a glucagon-like peptide-1 (GLP-1) antagonist that competes with endogenous GLP-1 for the GLP-1R, counteracting the effects of excessive GLP-1 secretion. Exendin(9-39) amide acetate can be utilized in Postbariatric hypoglycemia (PBH) research .

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Substance P

33 Cited Publications

Cat. No.: HY-P0201

CAS No.: 33507-63-0

Synonyms: Neurokinin P

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Endocrinology

Target:

Neurokinin Receptor Endogenous Metabolite

Substance P (Neurokinin P) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

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Substance P TFA

33 Cited Publications

Cat. No.: HY-P0201A

CAS No.: 148470-19-3

Synonyms: Neurokinin P TFA

Target:

Neurokinin Receptor Endogenous Metabolite

Research Areas:

Neurological Disease Metabolic Disease Cancer

Substance P TFA (Neurokinin P TFA) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

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Oxytocin

28 Cited Publications

Cat. No.: HY-17571

CAS No.: 50-56-6

Synonyms: α-Hypophamine; Oxytocic hormone

Category:

Natural Products Monophenols Animals Phenols Endogenous metabolite Disease Research Fields Endocrinology

Target:

Oxytocin Receptor Endogenous Metabolite

Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma ^[2].

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Oxytocin acetate

28 Cited Publications

Cat. No.: HY-17571A

CAS No.: 6233-83-6

Synonyms: α-Hypophamine acetate; Oxytocic hormone acetate

Category:

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Oxytocin Receptor Endogenous Metabolite

Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma ^[2].

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α-MSH

24 Cited Publications

Cat. No.: HY-P0252

CAS No.: 581-05-5

Synonyms: α-Melanocyte-Stimulating Hormone

Target:

Melanocortin Receptor

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology

α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC) ^[2].

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α-MSH TFA

24 Cited Publications

Cat. No.: HY-P0252A

CAS No.: 171869-93-5

Synonyms: α-Melanocyte-Stimulating Hormone TFA

Target:

Melanocortin Receptor

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology

α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC) ^[2].

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LSKL, Inhibitor of Thrombospondin (TSP-1)

18 Cited Publications

Cat. No.: HY-P0299

CAS No.: 283609-79-0

Target:

TGF-β Receptor

Research Areas:

Cancer

LSKL, Inhibitor of Thrombospondin (TSP-1) is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) can readily crosse the blood-brain barrier ^[2].

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LSKL, Inhibitor of Thrombospondin (TSP-1) TFA

18 Cited Publications

Cat. No.: HY-P0299A

CAS No.: 2828433-17-4

Target:

TGF-β Receptor

Research Areas:

Cancer

LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) TFA can readily crosse the blood-brain barrier ^[2].

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Gastrin I, human

17 Cited Publications

Cat. No.: HY-P1097

CAS No.: 10047-33-3

Target:

Cholecystokinin Receptor

Research Areas:

Endocrinology

Gastrin I, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor.

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Melittin

17 Cited Publications

Cat. No.: HY-P0233

CAS No.: 20449-79-0

Target:

Phospholipase

Research Areas:

Inflammation/Immunology Cancer

Melittin is a PLA₂ activator, stimulates the activity of the low molecular weight PLA₂, while it does not the increase activity of the high molecular weight PLA₂ ^[2].

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Melittin TFA

17 Cited Publications

Cat. No.: HY-P0233A

Target:

Phospholipase

Research Areas:

Infection Cancer

Melittin TFA is a PLA₂ activator, stimulates the activity of the low molecular weight PLA₂, while it does not the increase activity of the high molecular weight PLA₂ ^[2].

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WRW4

14 Cited Publications

Cat. No.: HY-P1119

CAS No.: 878557-55-2

Target:

Formyl Peptide Receptor (FPR)

Research Areas:

Neurological Disease

WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC₅₀ of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .

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Icatibant acetate

13 Cited Publications

Cat. No.: HY-108896

CAS No.: 138614-30-9

Purity: 99.85%

Synonyms: HOE 140 acetate

Target:

Bradykinin Receptor

Research Areas:

Inflammation/Immunology

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC₅₀ and K_i of 1.07 nM and 0.798 nM respectively ^[2] .

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