6 Results for "

NIH 10498

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "NIH 10498" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-B1178
CAS No.: 486-56-6
Synonyms: (-)-Cotinine; (S)-Cotinine; NIH-10498
Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases .
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Cat. No.: HY-B1178S
CAS No.: 110952-70-0
Synonyms: (±)-Cotinine-d3; (Rac)-NIH-10498-d3
(Rac)-Cotinine-d3 is the deuterium labeled (Rac)-Cotinine .
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Cat. No.: HY-B1178R
CAS No.: 486-56-6
Synonyms: (-)-Cotinine (Standard); (S)-Cotinine (Standard); NIH-10498 (Standard)
Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke
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Cat. No.: HY-B1178S1
CAS No.: 350818-68-7
Synonyms: (±)-Cotinine-d4; (Rac)-NIH-10498-d4
(Rac)-Cotinine-d4 is the deuterium labeled (Rac)-Cotinine .
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Cat. No.: HY-B1178A
CAS No.: 32162-64-4
Synonyms: (+)-Cotinine; (R)-Cotinine; (R)-NIH-10498
Target:  

nAChR

Research Areas:  

Neurological Disease

R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs .
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Cat. No.: HY-B1178S2
CAS No.: 2241872-22-8
Synonyms: (±)-Cotinine-d7; (Rac)-NIH-10498-d7
(Rac)-Cotinine-d7 is deuterium labeled Cotinine.
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