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Isoforms Recommended:	NOX4

Results for "

NOX4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NADPH Oxidase (14) Akt (1) Angiotensin-converting Enzyme (ACE) (1) AP-1 (1) Apoptosis (1) COX (1) DNA/RNA Synthesis (2) Glutathione Peroxidase (1) HSV (1) Interleukin Related (1) JNK (1) mTOR (1) nAChR (1) NF-κB (1) NO Synthase (1) p38 MAPK (1) Parasite (1) PI3K (1) PKC (1) PROTACs (1) Reactive Oxygen Species (ROS) (5) Reference Standards (1) Small Interfering RNA (siRNA) (3) SOD (1) STAT (1) TGF-beta/Smad (1) TGF-β Receptor (2) TNF Receptor (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Endocrinology (1) Inflammation/Immunology (7) Metabolic Disease (8) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: NADPH Oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100111

GLX351322 Maximum Cited Publications 47 Publications Verification	NADPH Oxidase	Metabolic Disease
GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC₅₀ of 5 μM.

HY-N3610

Coclaurine 1 Publications Verification	nAChR	Cancer
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum with anticancer activity. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. Coclaurine is a key molecule in S. tetrandra responsible for EFHD2 inhibition. Coclaurine can downregulate EFHD2-related NOX4-ABCC1 signaling and enhanced Cisplatin (HY-17394) sensitivity. Coclaurine suppresses the stemness and metastatic properties of NSCLC cells. Coclaurine disrupts the interaction between the transcription factor FOXG1 and the EFHD2 promoter, leading to a reduction in EFHD2 transcription ^[4].

HY-120801

APX-115 2 Publications Verification Ewha-18278	NADPH Oxidase	Metabolic Disease Inflammation/Immunology
APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for *Nox1, Nox2* and *Nox4*, respectively. APX-115 effectively prevents kidney injury .

HY-120801A

APX-115 free base 2 Publications Verification Ewha-18278 free base; Isuzinaxib free base	NADPH Oxidase	Inflammation/Immunology Endocrinology
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for *Nox1, Nox2* and *Nox4*, respectively. APX-115 free base effectively prevents kidney injury .

HY-152026

NADPH oxidase-IN-1	NADPH Oxidase	Neurological Disease
NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits *Nox2* and *Nox4* with IC₅₀s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .

HY-N2000

Bellidifolin 1 Publications Verification	STAT PI3K mTOR Akt	Neurological Disease Inflammation/Immunology Cancer
Bellidifolin is an orally active compound with antiproliferative, anti-inflammatory and antioxidant properties. Bellidifolin modulates key signaling pathways including STAT3, PI3K-Akt, mTOR and *BRD4, and inhibits the viral protein R (Vpr). Bellidifolin induces cell cycle arrest and apoptosis*, exerts significant antifibrotic effects, and protects the heart, liver and nervous system. Bellidifolin is applicable to the research of various diseases such as lung cancer, non-alcoholic fatty liver disease, myocardial hypertrophy and ischemic cranial nerve injury ^[4] .

HY-RS09461

NOX4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) NADPH Oxidase	Others
NOX4 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NOX4 Human Pre-designed siRNA Set A NOX4 Human Pre-designed siRNA Set A

HY-RS09462

Nox4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) NADPH Oxidase	Others
Nox4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nox4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nox4 Mouse Pre-designed siRNA Set A Nox4 Mouse Pre-designed siRNA Set A

HY-RS09463

Nox4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) NADPH Oxidase	Others
Nox4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nox4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nox4 Rat Pre-designed siRNA Set A Nox4 Rat Pre-designed siRNA Set A

HY-N9097

Niazirin	Reactive Oxygen Species (ROS) SOD Glutathione Peroxidase PKC NADPH Oxidase	Metabolic Disease Inflammation/Immunology
Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits *Nox4* protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis .

HY-170540

NOX4-IN-1	NADPH Oxidase TGF-beta/Smad Reactive Oxygen Species (ROS)	Inflammation/Immunology
NOX4-IN-1 (Compound 14m) is the inhibitor for NADPH oxidase 4 (NOX4), and blocks the generation of ROS. NOX4-IN-1 inhibits TGF-β1/Smad signaling pathway, decreases the expression of fibrosis-related proteins. NOX4-IN-1 inhibits the cell migration of NRK-49F .

HY-148936

GLX481372	NADPH Oxidase Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GLX481372 is a NADPH Oxidase (NOX) inhibitor. GLX481372 potently inhibits *NOX4/5* activities with IC₅₀ values of 0.68 and 0.57 μM. GLX481372 also has weak inhibitory activity against NOX1, NOX2, and NOX3, with IC₅₀ values of 7, 16 and 3.2 μM respectively. GLX481372 can inhibit ROS production. GLX481372 can be used for the researches of inflammation, cardiovascular and metabolic disease, such as diabetes .

HY-N16527

7-O-Galloyl-D-sedoheptulose	TNF Receptor Interleukin Related NADPH Oxidase Reactive Oxygen Species (ROS) NF-κB COX NO Synthase JNK AP-1 TGF-β Receptor	Metabolic Disease
7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. 7-O-Galloyl-D-sedoheptulose lowers the serum levels of glucose, leptin, insulin, C-peptide, resistin, TNF-α, IL-6, and increases the serum level of adiponectin. 7-O-Galloyl-D-sedoheptulose significantly reduces the levels of ROS and lipid peroxidation products (TBARS) by down-regulating the protein expression of NADPH oxidase subunit Nox-4 and p22phox. 7-O-Galloyl-D-sedoheptulose down-regulates NF-κB and related pro-inflammatory factors (COX-2, iNOS), inhibits the phosphorylation of JNK and the activity of its downstream AP-1. 7-O-Galloyl-D-sedoheptulose reduces the expression of TGF-β1 and fibronectin, indicating its potential in anti-tissue fibrosis. 7-O-Galloyl-D-sedoheptulose can be used for the study of type 2 diabetes and its hepatic and pancreatic complications .

HY-153978

GLX481369	NADPH Oxidase	Others
GLX481369 is a redox active substance. GLX481369 is a *Nox4* inhibitor. GLX481369 has antioxidant effects .

HY-158062

LC-1-40	PROTACs DNA/RNA Synthesis Apoptosis	Cancer
LC-1-40 is a PROTAC that selectively degrades NUDT1 (DC₅₀=0.97 nM). LC-1-40 selectively inhibits MYCN-induced tumor growth in mouse models. LC-1-40 also induces nucleotide damage and apoptosis in MYCN-associated tumors. LC-1-40 can be used in cancer research . (Red: NUDT1 binder; Blue: CRBN ligand; Black: Linker).

HY-100111R

GLX351322 (Standard)	NADPH Oxidase Reference Standards	Metabolic Disease
GLX351322 (Standard) is the analytical standard of GLX351322 (HY-100111). This product is intended for research and analytical applications. GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.

HY-124487

GK-136901	NADPH Oxidase TGF-β Receptor Reactive Oxygen Species (ROS) p38 MAPK	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GK-136901 is an orally active, dual Nox1/Nox4 NADPH oxidase inhibitor with a K_i of 160 nM for *Nox1* and 165 nM for *Nox4. GK-136901 potently blocks high glucose-induced intracellular reactive oxygen species production, p38-MAPK* phosphorylation, and upregulation of TGF-β1/2 and fibronectin (fibronectin) in renal cells. GK-136901 also inhibits the proliferation of mouse pulmonary vascular cells under hypoxic conditions. GK-136901 is applicable to the research on the pathogenesis of type 2 diabetic nephropathy, high glucose-related renal lesions and pulmonary hypertension ^[4].

HY-105111

P-536	Parasite Angiotensin-converting Enzyme (ACE) HSV DNA/RNA Synthesis	Cardiovascular Disease Metabolic Disease
P-536 is a ACE inhibitor that also inhibits herpes simplex virus HSV-1 thymidine kinase and Trypanosoma cruzi RNA polymerase. By inhibiting the renin-angiotensin system, downregulating the expression of AT1R and *NOX4, and reducing oxidative stress* (decreasing plasma hydrogen peroxide (H₂O₂) and 8-isoprostaglandin levels), P-536 effectively reduces systolic blood pressure and improves vascular reactivity. P-536 also inhibits the replication of DNA/RNA viruses such as HSV-1 by blocking nucleotide metabolism and nucleic acid synthesis, competitively inhibits RNA synthesis in Trypanosoma cruzi, and inhibits amastigote replication, thereby impeding its growth. P-536 is suitable for research on hypertension, insulin resistance, and Chagas disease ^[4].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3610

Coclaurine 1 Publications Verification	Alkaloids Structural Classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm. Source Classification	nAChR
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum with anticancer activity. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. Coclaurine is a key molecule in S. tetrandra responsible for EFHD2 inhibition. Coclaurine can downregulate EFHD2-related NOX4-ABCC1 signaling and enhanced Cisplatin (HY-17394) sensitivity. Coclaurine suppresses the stemness and metastatic properties of NSCLC cells. Coclaurine disrupts the interaction between the transcription factor FOXG1 and the EFHD2 promoter, leading to a reduction in EFHD2 transcription ^[4].

HY-N2000

Bellidifolin 1 Publications Verification	Infection Structural Classification Xanthones Classification of Application Fields Swertia bimaculata (Sieb. et Zucc.) Hook. f. et Thoms. ex C. B. Clark Gentianaceae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	STAT PI3K mTOR Akt
Bellidifolin is an orally active compound with antiproliferative, anti-inflammatory and antioxidant properties. Bellidifolin modulates key signaling pathways including STAT3, PI3K-Akt, mTOR and *BRD4, and inhibits the viral protein R (Vpr). Bellidifolin induces cell cycle arrest and apoptosis*, exerts significant antifibrotic effects, and protects the heart, liver and nervous system. Bellidifolin is applicable to the research of various diseases such as lung cancer, non-alcoholic fatty liver disease, myocardial hypertrophy and ischemic cranial nerve injury ^[4] .

HY-N9097

Niazirin	Structural Classification Moringa oleifera Lam. Moringaceae Plants Saccharides Monosaccharides Source Classification	Reactive Oxygen Species (ROS) SOD Glutathione Peroxidase PKC NADPH Oxidase
Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits *Nox4* protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis .

HY-N16527

7-O-Galloyl-D-sedoheptulose	Structural Classification Cornaceae Cornus officinalis Sieb. et Zucc. Phenols Polyphenols Plants Source Classification	TNF Receptor Interleukin Related NADPH Oxidase Reactive Oxygen Species (ROS) NF-κB COX NO Synthase JNK AP-1 TGF-β Receptor
7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. 7-O-Galloyl-D-sedoheptulose lowers the serum levels of glucose, leptin, insulin, C-peptide, resistin, TNF-α, IL-6, and increases the serum level of adiponectin. 7-O-Galloyl-D-sedoheptulose significantly reduces the levels of ROS and lipid peroxidation products (TBARS) by down-regulating the protein expression of NADPH oxidase subunit Nox-4 and p22phox. 7-O-Galloyl-D-sedoheptulose down-regulates NF-κB and related pro-inflammatory factors (COX-2, iNOS), inhibits the phosphorylation of JNK and the activity of its downstream AP-1. 7-O-Galloyl-D-sedoheptulose reduces the expression of TGF-β1 and fibronectin, indicating its potential in anti-tissue fibrosis. 7-O-Galloyl-D-sedoheptulose can be used for the study of type 2 diabetes and its hepatic and pancreatic complications .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P790059

	NOX4 Protein, Human (Cell-Free, His) NOX4; RENOX; NADPH oxidase 4; Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase	Human	E. coli Cell-free
	When NOX4 protein complexes with CYBA/p22phox, superoxide is generated in cells. It regulates signaling cascades and inhibits phosphatases. NOX4 Protein, Human (His) is the recombinant human-derived NOX4, expressed by E. coli Cell-free, with N-10*His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IP (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Polyclonal (1) Monoclonal (1) Recombinant (1)
Modification:	Unmodified (2)

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HY-P80762

	NADPH Oxidase 4 Antibody NADPH oxidase 4; Kidney oxidase-1; KOX-1; KOX1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; NOX4; RENOX	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	NADPH Oxidase 4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to NADPH Oxidase 4.

HY-P80762A

	NADPH Oxidase 4 Antibody (YA4640) 1 Publications Verification NADPH oxidase 4; Kidney oxidase-1; KOX-1; KOX1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; NOX4; RENOX	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	NADPH Oxidase 4 Antibody (YA4640) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NADPH Oxidase 4.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

NOX4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NOX4 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nox4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Nox4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nox4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nox4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Nox4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nox4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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