25-Methoxyalisol F
25-Methoxyalisol F is a regulator of NOX4 and phosphorylated Nrf2 with anti-pulmonary fibrosis activity. 25-Methoxyalisol F modulates the NOX4-Nrf2 signaling pathway, regulates the expression of NOX4 and p-Nrf2, and ameliorates TGF-β1-induced cellular damage. 25-Methoxyalisol F can be used in studies related to pulmonary fibrosis.
For research use only. We do not sell to patients.
- CAS No.: 2221029-53-2
- Formula: C31H50O5
- Molecular Weight:502.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
25-Methoxyalisol F (10 μM) significantly ameliorates TGF-β1-induced cell damage in BEAS-2B cells, increasing cell viability to 1.207[1].
25-Methoxyalisol F (1 μM) exhibits less than 50% inhibition of human and mouse 11β-HSD1 when tested in HEK-293 cell microsomes overexpressing the enzyme[2].
25-Methoxyalisol F is a novel protostane-type triterpenoid isolated from the rhizomes of Alisma orientale[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2221029-53-2
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Molecular Weight 502.73
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Formula C31H50O5
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SMILES
C[C@@]12[C@@]3([C@]([C@H](CC1=C4[C@](O[C@](C[C@H]4C)([H])[C@@H](O)C(C)(C)OC)([H])C2)O)([H])[C@@]5([C@@](C(C)(C(CC5)=O)C)([H])CC3)C)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Li HM, et al. Protostane-Type Triterpenoids from Alisma orientale. Chemistry & biodiversity. 2017 Dec;14(12). [Content Brief]
[3]. Feng L, et al. Alisma genus: Phytochemical constituents, biosynthesis, and biological activities. Phytotherapy research : PTR. 2021 Apr;35(4):1872-1886. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
25-Methoxyalisol F Related Classifications
HY-N20728 Related Classifications
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