Protostane-Type Triterpenoids from Alisma orientale

  • Chem Biodivers. 2017 Dec;14(12). doi: 10.1002/cbdv.201700452.
Hong-Mei Li  1  2 ,  Xue-Jiao Chen  1 ,  Dan Luo  1 ,  Min Fan  1 ,  Zhi-Jun Zhang  1 ,  Li-Yan Peng  1 ,  Xing-De Wu  1 ,  Rong-Tao Li  2 ,  Xu Ji  1 ,  Qin-Shi Zhao  1
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • 2. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
PMID: 29139211 DOI: 10.1002/cbdv.201700452
Abstract

Twenty-eight protostane triterpenoids, including a new degraded one (1), nine new ones (2 - 10), and two new natural ones (11 and 12), have been isolated from the dried rhizomes of Alisma orientale. Alisol R (1) was the first 20,21,22,23,24,25,26,27-octanorprotostane triterpenoid. The absolute configurations of 25-methoxyalisol F (2) and 16β-hydroperoxyalisol B 23-acetate (3) were determined by X-ray diffraction analysis. In addition, alismaketone-B 23-acetate (28) showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.

Keywords
Alisma orientale; Alismataceae; Alismatis Rhizoma; Protostane triterpenoids; Vasorelaxant activity.
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