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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
PBK/TOPK+Inhibitors
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "PBK/TOPK+Inhibitors" in MCE Product Catalog:
4
4 Cited Publications
HI-TOPK-032 is a potent and specific TOPK inhibitor.
4
4 Cited Publications
Cat. No.: HY-18621
CAS No.: 1338540-63-8
OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells . OTS514 induces cell cycle arrest and apoptosis .
Cat. No.: HY-19718
CAS No.: 1338542-14-5
OTS964 is an orally active, high affinity and selective TOPK inhibitor with an IC50 of 28 nM . OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM .
Cat. No.: HY-122860
CAS No.: 2300981-68-2
SKLB-C05 is a novel selective, orally active TOPK inhibitor, with an IC50 of 0.5 nM. SKLB-C05 selectively inhibit TOPK kinase. SKLB-C05 induces Apoptosis, downregulates c-Myc, γ-H2AX, activates p53, blocks FAK/Src medicated migration-related signaling. SKLB-C05 disturbs cell mitosis. SKLB-C05 shows anticancer activity only against TOPK-positive colorectal cancer .
Cat. No.: HY-18621A
CAS No.: 2319647-76-0
OTS514 hydrochloride is a highly potent TOPK inhibitor, which inhibits TOPK kinase activity with a median inhibitory concentration (IC50) value of 2.6 nM. OTS514 hydrochloride strongly suppresses the growth of TOPK-positive cancer cells . OTS514 hydrochloride induces cell cycle arrest and apoptosis .
Cat. No.: HY-RS10101
Target:
Research Areas:
PBK Human Pre-designed siRNA Set A contains three designed siRNAs for PBK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10102
Target:
Research Areas:
Pbk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pbk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10103
Target:
Research Areas:
Pbk Rat Pre-designed siRNA Set A contains three designed siRNAs for Pbk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-18621B
CAS No.: 1338541-25-5
(S)-OTS514 is the S enantiomer of OTS514 (HY-18621). OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells . OTS514 induces cell cycle arrest and apoptosis .
Cat. No.: HY-101550R
CAS No.: 487020-03-1
Target:
Research Areas:
HI-TOPK-032 (Standard) is the analytical standard of HI-TOPK-032 (HY-101550). This product is intended for research and analytical applications. HI-TOPK-032 is a potent and specific TOPK inhibitor.
Cat. No.: HY-P87977
Synonyms: TOPK, PBK, Lymphokine-activated killer T-cell-originated protein kinase, Cancer/testis antigen 84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, T-LAK cell-originated protein kinase, CT84, SPK
Cat. No.: HY-P81511
Synonyms: PBK; TOPK; Lymphokine-activated killer T-cell-originated protein kinase; Cancer/testis antigen 84; CT84; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinas
Cat. No.: HY-P81511A
Synonyms: PBK; TOPK; Lymphokine-activated killer T-cell-originated protein kinase; Cancer/testis antigen 84; CT84; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinas
Cat. No.: HY-P77122
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PBK; Lymphokine-Activated Killer T-Cell-Originated Protein Kinase; PDZ Binding Kinase; Spermatogenesis-Related Protein Kinase; Nori-3; Epididymis Luminal Protein 164; TOPK; MAPKK-Like Protein Kinase; CT84; FLJ14385; SPK; Serine/Threonine Protein Kinase; T
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-122859
CAS No.: 2252153-94-7
ADA-07 is a TOPK inhibitor with activity at the ATP-binding pocket that does not inhibit MEK1 activity. ADA-07 suppresses solar ultraviolet (SUV)-induced phosphorylation of ERK1/2, p38, and JNKs, and inhibits AP-1 activity. ADA-07 attenuates tumor incidence, multiplicity, and volume in SUV-exposed SKH-1 hairless mice. ADA-07 can be used for the research of solar ultraviolet-induced skin carcinogenesis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
