2252153-94-7
Chemical Structure
ADA-07
- CAS No.: 2252153-94-7
- Formula:C18H20N2O2
- Molecular Weight:296.37
IUPAC Name: (Z)-5-(adamantan-1-yl)-3-(hydroxyimino)indolin-2-one
InChIKey: ZCPHOPFAADQVRT-UHFFFAOYSA-N
SMILES: O=C1NC2=CC=C(C=C2C1=NO)C34CC5CC(CC(C5)C3)C4
Biological Activity: ADA-07 is a TOPK inhibitor with activity at the ATP-binding pocket that does not inhibit MEK1 activity. ADA-07 suppresses solar ultraviolet (SUV)-induced phosphorylation of ERK1/2, p38, and JNKs, and inhibits AP-1 activity. ADA-07 attenuates tumor incidence, multiplicity, and volume in SUV-exposed SKH-1 hairless mice. ADA-07 can be used for the research of solar ultraviolet-induced skin carcinogenesis[1].
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ADA-07 | ADA-07 is a TOPK inhibitor with activity at the ATP-binding pocket that does not inhibit MEK1 activity. ADA-07 suppresses solar ultraviolet (SUV)-induced phosphorylation of ERK1/2, p38, and JNKs, and inhibits AP-1 activity. ADA-07 attenuates tumor incidence, multiplicity, and volume in SUV-exposed SKH-1 hairless mice. ADA-07 can be used for the research of solar ultraviolet-induced skin carcinogenesis. | |||||||||||||||||||||
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