![7-[(2-Aminoethyl)carbamoyl]heptanoic acid](https://file.medchemexpress.com/product_pic/hy-182982.gif "Click to View 7-[(2-Aminoethyl)carbamoyl]heptanoic acid Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
PDL1 degrader-3
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "PDL1 degrader-3" in MCE Product Catalog:
Cat. No.: HY-182239
CAS No.: 2488699-00-7
Target:
Research Areas:
PDL1 degrader-3 (compound e24) is a DUBTAC-like PD-L1 degrader. PDL1 degrader-3 inhibits CSN5 enzymatic activity, increases PD-L1 ubiquitination, and induces PD-L1 degradation via the ubiquitin-proteasome pathway, reducing PD-L1 expression on tumor cell membranes. PDL1 degrader-3 blocks PD-1/PD-L1 interaction, activates the tumor immune microenvironment, enhances tumor-infiltrating T-cell immunity, and inhibits activation of immunosuppressive MDSCs and Tregs. PDL1 degrader-3 exerts antitumor effects in mouse tumor models. PDL1 degrader-3 can be used for the research of colorectal cancer, lung cancer [1].
Cat. No.: HY-182982
CAS No.: 1251828-93-9
Target:
Research Areas:
7-[(2-Aminoethyl)carbamoyl]heptanoic acid is a PROTAC linker that can be used to synthesize PROTAC molecules, such as PROTAC PD-L1 Degrader-3 (HY-182959) [1].
Cat. No.: HY-182980
Research Areas:
N-(8-Carboxyoctanoyl)-deacetyl BMS-202 is a target protein ligand-linker conjugate. N-(8-Carboxyoctanoyl)-deacetyl BMS-202 contains the target protein PD-1/PD-L1 ligand and a PROTAC linker. N-(8-Carboxyoctanoyl)-deacetyl BMS-202 can be used for the synthesis of PROTAC PD-L1 Degrader-3 (HY-182959) [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
