3 Results for "

PI3K/Akt/mTOR-IN-6

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "PI3K/Akt/mTOR-IN-6" in MCE Product Catalog:

PI3K/Akt/mTOR-IN-6
PI3K/Akt/mTOR-IN-6
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Cat. No.: HY-180853
Target:  

PI3K Akt mTOR Apoptosis Mitochondrial Metabolism

Research Areas:  

Cancer

PI3K/Akt/mTOR-IN-6 (Compound JW4) is an orally active PI3K/Akt/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-6 induces Apoptosis in cells via the mitochondrial pathway. PI3K/Akt/mTOR-IN-6 shows potent anti-NSCLC activity .
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2
Brassinin
Brassinin
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2 Cited Publications
Cat. No.: HY-111334
CAS No.: 105748-59-2
Purity:  99.74%
Synonyms: BrassININe
Category:  

Beassica pekinensis (Lour. ) Rupr. Alkaloids Cruciferae Cosmetic Research Plants Disease Research Fields Cancer Indole Alkaloids

Target:  

Endogenous Metabolite Indoleamine 2,3-Dioxygenase (IDO) Apoptosis Autophagy Paraptosis Reactive Oxygen Species (ROS) Tie Akt PERK PI3K mTOR Ribosomal S6 Kinase (RSK)

Brassinin is an indole derivative found in cruciferous plants. Brassinin acts as an IDO inhibitor (Ki = 97.7 μM). Brassinin inhibits angiogenesis and induces apoptosis, autophagy, paraptosis, ROS production, and ER stress. Brassinin selectively stimulates lysosomal degradation of Tie2 and promotes lysosomal and proteasomal degradation of FGFR1 in endothelial cells, downregulating AKT and ERK phosphorylation. Brassinin inhibits endothelial cell proliferation, migration, tube formation, spheroid sprouting, and angiogenesis. Brassinin inhibits PI3K/Akt/mTOR/S6K1 signaling, upregulates p21 and p27, and induces G1 phase cell cycle arrest through RB hypophosphorylation. Brassinin inhibits tyrosinase catalytic activity, reduces tyrosinase mRNA, and inhibits MITF nuclear translocation. Brassinin is used for research on triple-negative breast cancer, chronic myeloid leukemia, colon cancer, glioma, atherosclerosis, and skin cancer .
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PI3K/mTOR Inhibitor-6
PI3K/mTOR Inhibitor-6
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Cat. No.: HY-147613
CAS No.: 2456295-59-1
Target:  

PI3K mTOR

Research Areas:  

Cancer

PI3K/mTOR Inhibitor-6 (Compound 19c) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-6 displays better stability in artificial gastric fluids than gedatolisib. PI3K/mTOR Inhibitor-6 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-6 has the potential for the research of cancer diseases .
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