105748-59-2
Chemical Structure
Brassinin
Synonym(s): Brassinine
- CAS No.: 105748-59-2
- Formula:C11H12N2S2
- Molecular Weight:236.37
IUPAC Name: methyl ((1H-indol-3-yl)methyl)carbamodithioate
InChIKey: QYKQWFZDEDFELK-UHFFFAOYSA-N
SMILES: S=C(NCC1=CNC2=CC=CC=C21)SC
Biological Activity: Brassinin is an indole derivative found in cruciferous plants. Brassinin acts as an IDO inhibitor (Ki = 97.7 μM). Brassinin inhibits angiogenesis and induces apoptosis, autophagy, paraptosis, ROS production, and ER stress. Brassinin selectively stimulates lysosomal degradation of Tie2 and promotes lysosomal and proteasomal degradation of FGFR1 in endothelial cells, downregulating AKT and ERK phosphorylation. Brassinin inhibits endothelial cell proliferation, migration, tube formation, spheroid sprouting, and angiogenesis. Brassinin inhibits PI3K/Akt/mTOR/S6K1 signaling, upregulates p21 and p27, and induces G1 phase cell cycle arrest through RB hypophosphorylation. Brassinin inhibits tyrosinase catalytic activity, reduces tyrosinase mRNA, and inhibits MITF nuclear translocation. Brassinin is used for research on triple-negative breast cancer, chronic myeloid leukemia, colon cancer, glioma, atherosclerosis, and skin cancer[1][2][3][4][5][6][7][8][9][10].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Brassinin | 99.80% | Brassinin is an indole derivative found in cruciferous plants. Brassinin acts as an IDO inhibitor (Ki = 97.7 μM). Brassinin inhibits angiogenesis and induces apoptosis, autophagy, paraptosis, ROS production, and ER stress. Brassinin selectively stimulates lysosomal degradation of Tie2 and promotes lysosomal and proteasomal degradation of FGFR1 in endothelial cells, downregulating AKT and ERK phosphorylation. Brassinin inhibits endothelial cell proliferation, migration, tube formation, spheroid sprouting, and angiogenesis. Brassinin inhibits PI3K/Akt/mTOR/S6K1 signaling, upregulates p21 and p27, and induces G1 phase cell cycle arrest through RB hypophosphorylation. Brassinin inhibits tyrosinase catalytic activity, reduces tyrosinase mRNA, and inhibits MITF nuclear translocation. Brassinin is used for research on triple-negative breast cancer, chronic myeloid leukemia, colon cancer, glioma, atherosclerosis, and skin cancer. | ||||||||||||||||||||
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References
- [1]. Gu Y, et al. Brassinin Promotes the Degradation of Tie2 and FGFR1 in Endothelial Cells and Inhibits Triple-Negative Breast Cancer Angiogenesis. Cancers. 2022 Jul 21;14(14):3540.
- [2]. Yang MH, et al. Brassinin Induces Apoptosis, Autophagy, and Paraptosis via MAPK Signaling Pathway Activation in Chronic Myelogenous Leukemia Cells. Biology. 2023 Feb 14;12(2):307.
- [3]. Izutani Y, et al. Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in human colon cancer cells. International journal of oncology. 2012 Mar;40(3):816-24.
- [4]. Chripkova M, et al. Brassinin and its derivatives as potential anticancer agents. Toxicology in vitro : an international journal published in association with BIBRA. 2014 Aug;28(5):909-15.
- [5]. Gaspari P, et al. Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. Journal of medicinal chemistry. 2006 Jan 26;49(2):684-92.
- [6]. Fergani J, et al. Brassinin Induces HS Signals and Improves Vascular Smooth Muscle Cell Functions. Molecules (Basel, Switzerland). 2025 Sep 17;30(18):3775.
- [7]. Lee MK, et al. Brassinin Abundant in Brassicaceae Suppresses Melanogenesis through Dual Mechanisms of Tyrosinase Inhibition. Foods (Basel, Switzerland). 2022 Dec 26;12(1):121.
- [8]. Rauniyar S, et al. Brassinin Inhibits Cell Survival and Autophagy via Modulation of ROS Production and the AMPKα-beclin1 Signaling Pathway in Gliomas. Phytotherapy research : PTR. 2026 Aug 31.
- [9]. Han BH, et al. Inhibitory effect of brassinin on TNF‑α‑induced vascular inflammation in human umbilical vein endothelial cells. Molecular medicine reports. 2017 Nov;16(5):6890-6895.
- [10]. Mehta RG, et al. Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage. Carcinogenesis. 1995 Feb;16(2):399-404.
