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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
PKC C1 domain
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "PKC C1 domain" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: EBC-46
Tigilanol tiglate (EBC-46) is a protein kinase C (PKC)/C1 domain activator. Tigilanol tiglate is associated with mitochondrial/endoplasmic reticulum (ER) dysfunction, leading to activation of the unfolded protein response (UPRmt/ER) and subsequent induction of ATP depletion, organelles expansion, Caspase activation, gasdermin E cleavage, and terminal necrosis. Tigilanol tiglate, as a small anti-tumor molecule with immunomodulatory effects, can be used in the study of head and neck squamous cell carcinoma and soft tissue sarcoma .
Cat. No.: HY-E70852
PKC is a family of serine/threonine kinases involved in several processes including proliferation, differentiation, apoptosis, and migration. PKCα is a classical PKC isoform that contains a C1 domain that binds to diacylglycerol (DAG). PKCα Recombinant Human Active Protein Kinase is a recombinant PKCα protein that can be used to study PKCα-related functions .
Cat. No.: HY-149489
CAS No.: 742104-91-2
Target:
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JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases .
Cat. No.: HY-118834
CAS No.: 70497-14-2
Synonyms: Lyngbyatoxin A
Target:
Cat. No.: HY-N19700
CAS No.: 124986-26-1
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Target:
Cat. No.: HY-184494
Research Areas:
GLI-IN-1 is a potent, PKC-dependent Gli inhibitor. GLI-IN-1 binds to the C1 domain of PKC, forms hydrogen-bonding interactions with the M239 residue, and mediates the inhibition of downstream Gli via a PKC-mediated, Smoothened-independent mechanism. GLI-IN-1 can be used in studies of Gli-driven cancers and osteogenic differentiation .
Cat. No.: HY-E70853
PKCδ is a PKC isoform. PKCδ is expressed ubiquitously among cells and tissues. It is activated by diacylglycerol produced by receptor-mediated hydrolysis of membrane inositol phospholipids as well as by tumor-promoting phorbol ester through the binding of these compounds to the C1 region in its regulatory domain. PKCδ Recombinant Human Active Protein Kinase is a recombinant PKCδ protein that can be used to study PKCδ-related functions .
Cat. No.: HY-155599
CAS No.: 2982527-11-5
HIV-1 protease-IN-10 (Compound 2) has HIV-1 latency reversing activity (IC50: 0.22 μM). HIV-1 protease-IN-10 binds to the PKCδ C1b domain (IC50: 0.69 μM). HIV-1 protease-IN-10 has stability against esterase-mediated hydrolysis .
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3-Heptanol is a biotransformation product of n-heptane. 3-Heptanol can act as the building block in the synthesis of 4-(3-adamantan-1-yl-ureido)-butyric acid and cyclohexanecarboxylic acid derivatives as sEH inhibitors. 3-Heptanol can be used as a solvent to form microenvironments around single-walled carbon nanotubes. 3-Heptanol can be used in the preperation of substituted pyrimidine derivatives as C1 domain-targeted isophthalate analogs to study their binding affinities towards PKCα isoform .
Cat. No.: HY-134058S
Synonyms: Butylethylcarbinol-d4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
