JH-131e-153
JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases.
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- No. CAS: 742104-91-2
- Fòrmula: C22H38O5
- Peso molecular:382.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
Munc13-1 C1 domain[1]
In Vitro
Munc13-1 is a target of the diacylglycerol second messenger pathway and plays a role in vesicle maturation during exocytosis. Participates in neurotransmitter release by acting on synaptic vesicle initiation prior to vesicle fusion, and participates in activity-dependent refilling of the easy-release vesicle pool (RRP).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 742104-91-2
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Peso molecular 382.53
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Fòrmula C22H38O5
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SMILES
CC(C)(C)C(OC[C@@](C/C1=C/CC(CC(C)C)CC(C)C)(CO)OC1=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JH-131e-153 Related Classifications
HY-149489 Related Classifications
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