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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
PROTAC BET Degrader-1
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "PROTAC BET Degrader-1" in MCE Product Catalog:
2
2 Cited Publications
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PROTAC BET Degrader-1 is a BRD2/BRD3/BRD4 PROTAC degrader. PROTAC BET Degrader-1 inhibits the growth of acute leukemia cells. PROTAC BET Degrader-1 is applicable to the research of acute leukemia .
Cat. No.: HY-175678
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PROTAC BRD2 BD1 Degrader-1 is a potent and selective BRD2 BD1 PROTAC degrader, with a DC50 of 65 nM, an EC50 of 423 nM, and a Kd of 69 nM against BRD2 BD1. PROTAC BRD2 BD1 Degrader-1 induces the formation of a ternary complex between the BET bromodomain and the VHL E3 ubiquitin ligase complex, triggering VCB-dependent degradation of the target bromodomain. PROTAC BRD2 BD1 Degrader-1 can be used in cancer research .
Cat. No.: HY-160262
CAS No.: 2571123-81-2
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PROTAC AR/BET protein degrader-1 (Compound 149) is an Androgen Receptor and BET (bromodomain and extra-terminal domain) protein degrader that can be used in cancer research .
Cat. No.: HY-130813
CAS No.: 2570470-39-0
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BET-IN-6 is a BET inhibitor. BET-IN-6 can be used as a Ligand for Target Protein for PROTAC for the synthesis of BRD2/BRD4 PROTAC degraders, such as PROTAC BRD2/BRD4 degrader-1 (HY-130612). BET-IN-6 can be used for cancer research .
Cat. No.: HY-130612
CAS No.: 2570470-42-5
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PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader, connected by ligands for Cereblon and BET. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, long-lasting, and unexpectedly selective removal of BRD4 and BRD2 over BRD3. PROTAC BRD2/BRD4 degrader-1 effectively inhibits solid tumors with low cytotoxic effect .
Cat. No.: HY-103633R
CAS No.: 2093386-22-0
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PROTAC BET Degrader-1 (Standard) is the analytical standard of PROTAC BET Degrader-1 (HY-103633). This product is intended for research and analytical applications. PROTAC BET Degrader-1 is a BRD2/BRD3/BRD4 PROTAC degrader. PROTAC BET Degrader-1 inhibits the growth of acute leukemia cells. PROTAC BET Degrader-1 is applicable to the research of acute leukemia .
Cat. No.: HY-130814
CAS No.: 2093387-50-7
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Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 (HY-130612). PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader .
Cat. No.: HY-W584512
CAS No.: 2093386-23-1
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Thalidomide-NH-CH2-COO (t-Bu) is a ligand for E3 ubiquitin ligase PROTAC BET Degrader-1 (HY-103633) .
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Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader . (From patent WO2017180417A1 compound s7).
Cat. No.: HY-175790
CAS No.: 2493425-86-6
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AR/BET ligand-1 is a AR/BET ligand, which can be used for the synthesis of PROTACs, such as PROTAC AR/BET protein degrader-1 (HY-160262) .
Cat. No.: HY-175791
CAS No.: 2703756-19-6
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Ethyl-Cha-thalidomide-NH2 is a conjugate of an E3 ligase and a linker, which can be used for the synthesis of PROTACs, such as PROTAC AR/BET protein degrader-1 (HY-160262) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
