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572

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35

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Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0666
    L-Aspartic acid
    4 Publications Verification

    		 Endogenous Metabolite Neurological Disease Inflammation/Immunology
    L-Aspartic aicd is an amino acid. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid
  • HY-14532
    Brincidofovir
    5 Publications Verification

    CMX001; HDP-CDV

    		 CMV HSV Orthopoxvirus Infection
    Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo .
    Brincidofovir
  • HY-W011556
    N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate

    TCFH

    		 Drug Isomer Cancer
    N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate (TCFH) is a powerful coupling and derivatizing reagent for ester prodrug synthesis. N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate can be used for antitumor drugs before medicine research .
    N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate
  • HY-N0666S8
    L-Aspartic acid-d3

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid-d3 is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-d3
  • HY-N0666S4
    L-Aspartic acid-13C4

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid- 13C4 is the 13C-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-13C4
  • HY-142209
    ABBV-167

    		Bcl-2 Family Cancer
    ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax .
    ABBV-167
  • HY-N0666A
    L-Aspartic acid potassium
    4 Publications Verification

    		 Endogenous Metabolite Neurological Disease Inflammation/Immunology
    Aspartic acid potassium is an amino acid. L-Aspartic aicd potassium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd potassium commonly used in the study of inflammatory conditions .
    L-Aspartic acid potassium
  • HY-W011963
    Melevodopa hydrochloride

    		Dopamine Receptor Neurological Disease
    Melevodopa hydrochloride is an effervescent Levodopa (HY-N0304) prodrug. Levodopa is an orally active metabolic precursor of neurotransmitters dopamine and has anti-allodynic effects and the potential for Parkinson's disease
    Melevodopa hydrochloride
  • HY-N0666B
    Aspartic acid calcium
    4 Publications Verification

    Calcium L-aspartate

    		 Endogenous Metabolite Inflammation/Immunology
    Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic aicd calcium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd calcium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd calcium commonly used in the study of inflammatory conditions .
    Aspartic acid calcium
  • HY-N0666C
    L-Aspartic aicd sodium
    4 Publications Verification

    Sodium L-aspartate

    		 Endogenous Metabolite Neurological Disease Inflammation/Immunology
    L-Aspartic aicd sodium is an amino acid. L-Aspartic aicd sodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd sodium commonly used in the study of inflammatory conditions .
    L-Aspartic aicd sodium
  • HY-N0666R
    L-Aspartic acid (Standard)
    1 Publications Verification

    		 Reference Standards Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid (Standard) is the analytical standard of L-Aspartic acid. This product is intended for research and analytical applications. L-Aspartic aicd is an amino acid. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid (Standard)
  • HY-N0666S
    L-Aspartic acid-13C

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid- 13C is a 13C labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-13C
  • HY-138218
    ALD-52

    1-Acetyl-LSD

    		 Drug Derivative 5-HT Receptor Neurological Disease
    ALD-52 (1-Acetyl-LSD) is a prodrug for LSD. ALD-52 shows an affinity to 5-HT1A, 5-HT2A and 5-HT2C with a sub>D values of 1054, 174 and 10.2 nM, respectively. ALD-52 is converted to LSD and induces a head-twitch response (HTR) in vivo. ALD-52 can be used for hallucinogen research .
    ALD-52
  • HY-108288
    Sulbactam pivoxil

    Pivsulbactam; CP 47904

    		 Beta-lactamase Antibiotic Bacterial Infection
    Sulbactam pivoxil (Pivsulbactam) is a prodrug of Sulbactam (HY-B0334) with oral activity. Sulbactam is a β-lactamase inhibitor with antibacterial activity. Sulbactam pivoxil is better absorbed than Sulbactam and results in higher serum levels after oral administration .
    Sulbactam pivoxil
  • HY-70003
    Carboxypeptidase G2 (CPG2) Inhibitor

    CPG2 Inhibitor

    		 Carboxypeptidase Cancer
    Carboxypeptidase G2 (CPG2) Inhibitor is a novel CPG2 inhibitor with an Ki of 0.3 μM. Carboxypeptidase G2 (CPG2) Inhibitor effectively neutralizes the CPG2 activity in non-tumor sites, allowing for earlier administration of the drug and forming a complementary strategy with antibody clearance strategies. Carboxypeptidase G2 (CPG2) Inhibitor can be used for the study of antibody-directed enzyme prodrug therapy (ADEPT) .
    Carboxypeptidase G2 (CPG2) Inhibitor
  • HY-178329
    ProAX

    		Endogenous Metabolite Metabolic Disease
    ProAX is an AXP prodrug which enhances intracellular ATP levels without inducing cytotoxicity. ProAX can be metabolized by intracellular enzymes such as esterases and phosphoamidases, resulting in the conversion to AMP, ADP, and ATP. ProAX has potential applications in the research of bioenergetic-molecule therapeutics .
    ProAX
  • HY-N0666D
    L-Aspartic aicd disodium
    4 Publications Verification

    Disodium L-aspartate

    		 Endogenous Metabolite Neurological Disease Inflammation/Immunology
    L-Aspartic acid disodium is an amino acid. L-Aspartic aicd disodium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd disodium commonly used in the study of inflammatory conditions .
    L-Aspartic aicd disodium
  • HY-N0666S3
    L-Aspartic acid-15N

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid- 15N is the 15N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-15N
  • HY-N0666S2
    DL-Aspartic acid-d3

    		Isotope-Labeled Compounds Endogenous Metabolite Inflammation/Immunology
    DL-Aspartic acid-d3 is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    DL-Aspartic acid-d3
  • HY-172314
    ACHM-025

    		Aldose Reductase Drug Derivative Cancer
    ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia .
    ACHM-025
  • HY-N0666S1
    L-Aspartic acid-13C4,15N

    		Endogenous Metabolite Cardiovascular Disease
    L-Aspartic acid- 13C4, 15N is the 13C-labeled and 15N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-13C4,15N
  • HY-178239
    DX-8951 Hydroxy-acid

    		Drug Metabolite AMPK Reactive Oxygen Species (ROS) Inflammation/Immunology
    DX-8951 Hydroxy-acid is a prodrug of phosphoramide. ProAX can effectively increase intracellular ATP levels. DX-8951 Hydroxy-acid activates the AMPK signaling pathway by increasing the AMP/ATP ratio. DX-8951 Hydroxy-acid can enhance mitochondrial function and antioxidant capacity while reducing reactive oxygen species (ROS) levels. DX-8951 Hydroxy-acid has shown significant anti-aging and longevity effects in both human fibroblast and nematode models .
    DX-8951 Hydroxy-acid
  • HY-126719
    R-1 Methanandamide Phosphate

    		Drug Derivative Neurological Disease
    R-1 Methanandamide Phosphate is a water-soluble prodrug analog of arachidonylethanolamide (AEA). AEA is an endogenous cannabinoid compound .
    R-1 Methanandamide Phosphate
  • HY-158329
    Alloc-DOX

    N-Alloc doxorubicin

    		 Apoptosis Topoisomerase Antibiotic AMPK Bacterial Autophagy Mitophagy HIV HBV Cancer
    Alloc-DOX (N-Alloc doxorubicin) is a Doxorubicin (HY-15142A) prodrug. The combination of a catalyst (such as nano-palladium) and alloc-DOX leads to a decrease in cell viability and tumour growth .
    Alloc-DOX
  • HY-176869
    EMC-AANL-DOX

    		Drug Derivative Cancer
    EMC-AANL-DOX is a legumain-activated prodrug conjugate of Doxorubicin (DOX) (HY-15142A). EMC-AANL-DOX shows antitumor activity in mouse models of neuroblastoma (NB), breast cancer (4T1), fibrosarcoma (HT1080), and colorectal cancer liver metastases (CT26). EMC-AANL-DOX can be used for cancer research .
    EMC-AANL-DOX
  • HY-177716
    Ciprofloxacin prodrug-1

    		Beta-lactamase Bacterial Infection
    Ciprofloxacin prodrug-1 (Compound 35) is an activated prodrug of β-lactase. Ciprofloxacin prodrug-1 exhibits good antibacterial activity against bacteria containing β-lactase (MIC = 63 nM). After being hydrolyzed by β-lactase, Ciprofloxacin prodrug-1 can release Ciprofloxacin (HY-B0356), thereby inhibiting the activity of DNA gyrase. Ciprofloxacin prodrug-1 can be used to study infections caused by enzyme-producing drug-resistant bacteria (such as uropathogenic Escherichia coli) .
    Ciprofloxacin prodrug-1
  • HY-175863
    2-PMPA prodrug 1

    		Others Neurological Disease
    2-PMPA prodrug 1 (compound 18b) is an orally active 2-PMPA prodrug with good oral bioavailability .
    2-PMPA prodrug 1
  • HY-179392
    Sunitinib-platinum(IV) prodrug-1

    		Apoptosis DNA Alkylator/Crosslinker VEGFR PDGFR Cancer
    Sunitinib-platinum(IV) prodrug-1 (Complex A) is a Pt(IV) prodrug based on Cisplatin (HY-17394), and this design aims to enable Pt(IV) to be reduced to active Pt(II) under intracellular reducing conditions, while simultaneously releasing a derivative of Sunitinib (HY-10255A) with tyrosine kinase inhibitor (TKI) activity. Sunitinib-platinum(IV) prodrug-1 exhibits excellent cytotoxicity against renal cell carcinoma (RCC), causing DNA crosslinking and apoptosis. Sunitinib-platinum(IV) prodrug-1 inhibits the VEGFR/PDGFR signaling pathway, suppressing tumor growth and angiogenesis. Sunitinib-platinum(IV) prodrug-1 can be used for research on renal cell carcinoma .
    Sunitinib-platinum(IV) prodrug-1
  • HY-N0666S6
    L-Aspartic acid-1,4-13C2

    		Endogenous Metabolite Inflammation/Immunology
    L-Aspartic acid-1,4- 13C2 is the 13C-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .
    L-Aspartic acid-1,4-13C2
  • HY-178239A
    DX-8951 Hydroxy-acid sodium

    		Drug Metabolite AMPK Reactive Oxygen Species (ROS) Inflammation/Immunology
    DX-8951 Hydroxy-acid sodium is a prodrug of phosphoramide. DX-8951 Hydroxy-acid sodium can effectively increase intracellular ATP levels. DX-8951 Hydroxy-acid sodium activates the AMPK signaling pathway by increasing the AMP/ATP ratio. DX-8951 Hydroxy-acid sodium can enhance mitochondrial function and antioxidant capacity while reducing reactive oxygen species (ROS) levels. DX-8951 Hydroxy-acid sodium has shown significant anti-aging and longevity effects in both human fibroblast and nematode models .
    DX-8951 Hydroxy-acid sodium
  • HY-133844
    Bisbentiamine

    		Drug Intermediate Others
    Bisbentiamine is a lipophilic thiamine prodrug with pH-dependent solubility. The bioavailability of Bisbentiamine is regulated by diet type, administration time, gastric acidity, and formulation .
    Bisbentiamine
  • HY-178516
    PROTAC CDK4/6/9 degrader 2

    		CDK PROTACs Cancer
    PROTAC CDK4/6/9 degrader 2 (Compound P4) is a CDK4/6/9 PROTAC prodrug with oral activity and low toxicity. PROTAC CDK4/6/9 degrader 2 can significantly inhibit tumor growth and suppress tumor lung metastasis. PROTAC CDK4/6/9 degrader 2 can be used in the research of cancer such as breast cancer. (Pink: CDK4/6/9 Ligand (HY-168440); Blue: CRBN Ligand (HY-178517); Black: Linker (HY-178512))
    PROTAC CDK4/6/9 degrader 2
  • HY-119011
    Pivampicillin

    		Antibiotic Bacterial Infection
    Pivampicillin is a penicillin antibiotic. Pivampicillin is a prodrug of Ampicillin (HY-B0522) .
    Pivampicillin
  • HY-W554614
    Diethylstilbestrol diphosphate

    Fosfestrol

    		 Estrogen Receptor/ERR Cancer
    Diethylstilbestrol diphosphate (Fosfestrol) is a diphosphate of diethylstilbestrol and an agonist of estrogen receptors. Diethylstilbestrol diphosphate is a prodrug of diethylstilbestrol and has a powerful anti-gonadotropin effect. Diethylstilbestrol diphosphate can be used in the research of prostate cancer .
    Diethylstilbestrol diphosphate
  • HY-161687
    Cisplatin/Dasatinib prodrug-1

    		Src Cancer
    Cisplatin/Dasatinib prodrug-1 (Compound 3) is a prodrug of Cisplatin (HY-17394) and Dasatinib (HY-10181). Cisplatin/Dasatinib prodrug-1 exhibits antiproliferative activity against A2780, MDA-MB-231, MCF7, HCT116, RD, Thp1 and HL60 cancer cells with IC50s of 0.1, 0.1, 0.36, 2.0, 0.4, 0.3 and 0.25 μM, respectively .
    Cisplatin/Dasatinib prodrug-1
  • HY-105373
    PNU 101850

    		Drug Intermediate Infection
    PNU 101850 is an Eperezolid (HY-10393) ester prodrug. PNU 101850 acquires antibacterial activity after conversion to the parent drug Eperezolid .
    PNU 101850
  • HY-14554
    Pomaglumetad methionil anhydrous

    LY2140023

    		 mGluR Neurological Disease
    Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research .
    Pomaglumetad methionil anhydrous
  • HY-105040
    Pomaglumetad methionil

    LY2140023 hydrate

    		 mGluR Neurological Disease
    Pomaglumetad methionil (LY2140023 hydrate) is an oral methionine prodrug of the potent specific mGlu2/3 receptor agonist LY404039 (HY-50906). Pomaglumetad methionil is well-tolerated and has a distinct safety profile, and can be used for schizophrenia .
    Pomaglumetad methionil
  • HY-118782A
    Ibuprofenamine hydrochloride

    Ibuprofen diethylaminoethyl ester hydrochloride

    		 Drug Derivative Inflammation/Immunology
    Ibuprofenamine (Ibuprofen diethylaminoethyl ester) hydrochloride, the prodrug of Ibuprofen (HY-78131), is a transdermal nonsteroidal anti-inflammatory agent (NSAID). Ibuprofenamine hydrochloride can be used for the study of rheumatoid arthritis and osteoarthritis .
    Ibuprofenamine hydrochloride
  • HY-123330
    GW695634

    		HIV Reverse Transcriptase Infection
    GW695634 is an orally active prodrug of GW678248. GW695634 undergoes amidolysis in vivo to release the active ingredient GW678248, thereby inhibiting viral replication. GW678248 is a non-nucleoside reverse transcriptase inhibitor (NNRTi) with potent antiviral activity against Efavirenz (HY-10572)-resistant and Nevirapine (HY-10570)-resistant HIV and AIDS viruses .
    GW695634
  • HY-161838
    ICT10336

    		ATM/ATR Cancer
    ICT10336 is a hypoxia-responsive prodrug of ATR inhibitor, AZD6738 (HY-19323). ICT10336 is hypoxia-activated and specifically releases AZD6738 only in hypoxic conditions in vitro. This can inhibit ATR activation (T1989 and S428 phosphorylation) and subsequently abrogate HIF1a-mediated adaptation of hypoxic cancers cells, thus selectively inducing cell death in 2D and 3D cancer models. ICT10336 is a metabolic substrate of CYPOR activity.
    ICT10336
  • HY-176810
    CDN prodrug-1

    		STING Cancer
    CDN prodrug-1 (Compound 2) is a STING ligand. CDN prodrug-1 consists of a cyclic dinucleotide (CDN) and a dialanine peptide linker. CDN prodrug-1 can be cleaved following internalization into endolysosomes by cathepsins and subsequently release the parent CDN. CDN prodrug-1 can be used for synthesis nanoparticles for drug delivery research .
    CDN prodrug-1
  • HY-108288R
    Sulbactam pivoxil (Standard)

    Pivsulbactam (Standard); CP 47904 (Standard)

    		 Beta-lactamase Reference Standards Antibiotic Bacterial Infection
    Sulbactam pivoxil (Standard) (Pivsulbactam (Standard)) is the analytical standard of Sulbactam pivoxil (HY-108288). This product is intended for research and analytical applications. Sulbactam pivoxil (Pivsulbactam) is a prodrug of Sulbactam (HY-B0334) with oral activity. Sulbactam is a β-lactamase inhibitor with antibacterial activity. Sulbactam pivoxil is better absorbed than Sulbactam and results in higher serum levels after oral administration .
    Sulbactam pivoxil (Standard)
  • HY-176771
    Tapinarof prodrug-1

    		Drug Intermediate Inflammation/Immunology
    Tapinarof prodrug-1 (Compound 31) is an orally active prodrug of Tapinarof (HY-109044). Tapinarof is an AhR agonist. Tapinarof prodrug-1 has an improving effect in the TNBS-induced mouse model of inflammatory bowel disease. Tapinarof prodrug-1 can be used in the research of inflammatory diseases .
    Tapinarof prodrug-1
  • HY-163849
    Mizoribine prodrug-1

    		Interleukin Related Inflammation/Immunology
    Mizoribine prodrug-1 (compound 18) is a oral active ester-based mizoribine (HY-17470) prodrug. Mizoribine prodrug-1 displays a inhibition of IL-2 production .
    Mizoribine prodrug-1
  • HY-B0255R
    Adefovir dipivoxil (Standard)

    GS 0840 (Standard)

    		 Reference Standards HBV Reverse Transcriptase Orthopoxvirus Endogenous Metabolite Infection Cancer
    Adefovir dipivoxil (Standard) is the analytical standard of Adefovir dipivoxil. This product is intended for research and analytical applications. Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the KCTD12-CDK1 interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type strains. Adefovir dipivoxil has antitumor activity against lung and colon cancer .
    Adefovir dipivoxil (Standard)
  • HY-109755
    PF-04064900

    		Bacterial Antibiotic Others
    PF-04064900 is a prodrug of sulopenem penem antibiotic .
    PF-04064900
  • HY-161336
    Alendronate prodrug-1

    		Bacterial Cancer
    Alendronate prodrug-1(compound 2) is an inhibitor of farnesyl diphosphate synthase (FPPS). Alendronate prodrug-1 has an antiproliferative effect with an IC50 value of 34.0 μM .
    Alendronate prodrug-1
  • HY-118983
    Pivampicillin hydrochloride

    		Antibiotic Bacterial Infection
    Pivampicillin hydrochloride is a penicillin antibiotic. Pivampicillin hydrochloride is a prodrug of Ampicillin (HY-B0522) .
    Pivampicillin hydrochloride
  • HY-157127
    Ketoprofen L-thyroxine ester

    		COX Metabolic Disease
    Ketoprofen L-thyroxine ester is a prodrug of Ketoprofen. Ketoprofen L-thyroxine ester reservoir and release ketoprofen slowly in the brain .
    Ketoprofen L-thyroxine ester

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