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Protein Disulfide Isomerases

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By Targets:	PDI (24) Antibiotic (2) Apoptosis (5) Bacterial (1) Endogenous Metabolite (2) Environmental Pollutants (1) Estrogen Receptor/ERR (1) Ferroptosis (1) Glutathione Peroxidase (1) Integrin (1) MDM-2/p53 (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Sirtuin (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (4) Infection (2) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (8)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

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Click Chemistry

Targets Recommended: PDI

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107193

Bacitracin 3 Publications Verification	Environmental Pollutants Antibiotic Bacterial PDI	Infection Cancer
Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .

HY-100432

LOC14 4 Publications Verification	PDI	Neurological Disease Inflammation/Immunology
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC₅₀ and K_d values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .

HY-B1228

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Antibiotic PDI	Infection
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum aminoglycoside Antibiotic with bactericidal activity against Gram-positive cocci, Gram-negative cocci, bacilli, and drug-resistant strains. Ribostamycin sulfate also acts as an inhibitor of protein disulfide isomerase (PDI), with a binding constant K_D of 319 μM for bovine PDI. Ribostamycin sulfate targets bacterial 16S ribosomal RNA and the 30S ribosomal subunit, causing translational misreading and thereby inhibiting bacterial protein synthesis. Ribostamycin sulfate disrupts the integrity of bacterial cell membranes, induces membrane pore formation, and leads to bacterial death. Ribostamycin sulfate can be used in studies related to bacterial infections .

HY-100430

CCF642 1 Publications Verification	Apoptosis PDI	Cancer
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC₅₀ of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

HY-114086

ML359	PDI	Cardiovascular Disease
ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC₅₀ of 250 nM. ML359 can prevent thrombus formation in vivo .

HY-100433

PACMA 31 5 Publications Verification	PDI	Cancer
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N2163

Mudanpioside C	PDI	Cardiovascular Disease
Mudanpioside C is a protein disulfide isomerase (PDI) inhibitor with a human IC₅₀ of 3.31 μM and human K_d of 3.9 μM. Mudanpioside C suppresses collagen-induced platelet aggregation, interferes with platelet activation, adhesion, and spreading. Mudanpioside C can be used for the research of cardiovascular diseases .

HY-111117

3-Methyltoxoflavin 1 Publications Verification	PDI	Cancer
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC₅₀ of 170 nM.

HY-117570

KSC-34	PDI	Neurological Disease
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC₅₀ of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family . KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-124866

PDI-IN-3	PDI	Neurological Disease
PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability .

HY-122895

E64FC26 2 Publications Verification	Apoptosis PDI	Cancer
E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC₅₀s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity .

HY-110172

PDI-IN-1	PDI	Cancer
PDI-IN-1 (Compound P1) is a cell-permeable human protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 1.7 μM. PDI-IN-1 has anti-cancer activity.

HY-122895A

(E/Z)-E64FC26	Apoptosis PDI	Cancer
(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC₅₀s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity .

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Cancer
4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

HY-170655

PDI-IN-4	PDI Integrin	Cardiovascular Disease
PDI-IN-4 (Compound 14d) is an inhibitor of **protein disulfide isomerase, with an IC₅₀ value of 0.48 μM. PDI-IN-4 suppresses platelet aggregation and thrombus formation by attenuating GPIIb/IIIa** activation without significantly causing cytotoxicity. PDI-IN-4 can be used in research on thrombosis .

HY-P2927

**Protein disulfide isomerase**	PDI	Cardiovascular Disease
Protein disulfide isomerase is a prototypic thiol isomerase that catalyzes the formation and cleavage of thiol-disulfide bonds during protein folding in the endoplasmic reticulum (ER). Protein disulfide isomerase can be used for the study of cardiovascular diseases .

HY-E70615

Protein Disulfide Isomerase, Human	Endogenous Metabolite	Cancer
Protein Disulfide Isomerase, Human, an oxidoreductase, is a mainly endoplasmic reticulum (ER) resident protein. Protein Disulfide Isomerase, Human plays an important role in maintaining cellular homeostasis through thiol oxidation/reduction cycling, chaperone action, and isomerization of client proteins .

HY-181574

PDI-IN-5	PDI Glutathione Peroxidase	Neurological Disease Cancer
PDI-IN-5 (compound 30z) is an allosteric-covalent inhibitor targeting protein disulfide isomerase (PDI) with a 2-chloro-pyrrolopyrimidin-4-one scaffold, with an IC₅₀ of 0.4 μM. PDI-IN-5 exhibits selectivity for ERp57 and GPX4, and inhibits glioblastoma. PDI-IN-5 can be used in glioblastoma-related research .

HY-100430R

CCF642 (Standard)	Apoptosis Reference Standards PDI	Cancer
CCF642 (Standard) is the analytical standard of CCF642 (HY-100430). This product is intended for research and analytical applications. CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

HY-W851050A

BAP2	PDI	Neurological Disease Cancer
BAP2 is an allosteric protein disulfide isomerase (PDI) inhibitor with a IC₅₀ of 0.85 μM. BAP2 binds to His256 in the b′ domain of PDI and exerts inhibitory effects through allosteric binding to the b′ domain. BAP2 upregulates GRP78. BAP2 inhibits the growth of glioblastoma cells. BAP2 can be used in studies related to glioblastoma .

HY-181573

TC8026	PDI Apoptosis	Neurological Disease Cancer
TC8026 is an allosteric-covalent inhibitor targeting **protein disulfide isomerase (PDI), with an IC₅₀ of 7 μM against human PDI. TC8026 induces endoplasmic reticulum stress-mediated apoptosis. TC8026 is a hit compound with PDI** inhibitory activity identified via high-throughput screening, and it can be used for the research of glioblastoma .

HY-W015811

3-N-Propylphenol	PDI	Metabolic Disease Inflammation/Immunology Cancer
3-N-Propylphenol is a small phenolic derivative containing a hydroxyl aryl group that competitively inhibits the binding of the peptide to pancreatic-specific protein disulfide isomerase (PDIp). 3-Propylphenol can be used for research on pancreatic-related diseases .

HY-100432R

LOC14 (Standard)	PDI Reference Standards	Neurological Disease Inflammation/Immunology
LOC14 (Standard) is the analytical standard of LOC14 (HY-100432). This product is intended for research and analytical applications. LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .

HY-100433R

PACMA 31 (Standard)	PDI Reference Standards	Cancer
PACMA 31 (Standard) is the analytical standard of PACMA 31 (HY-100433). This product is intended for research and analytical applications. PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N19464

Dicentrinone	PDI	Inflammation/Immunology Cancer
Dicentrinone is an orally active PDI inhibitor with an IC₅₀ value of 43.95 μM. Dicentrinone directly binds to PDI and suppresses cell proliferation and reduces cancer cell viability. Dicentrinone elicits anti-inflammatory and antioxidant effects by suppressing leukocyte migration, plasma leakage and paw edema, and scavenging free radicals. Dicentrinone can be used in the research of hepatoma, rheumatism and arthritis .

Bacitracin 3 Publications Verification	Structural Classification Classification of Application Fields Anti-aging Anti-parasitic Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Disease Research Fields Source Classification Cancer	Environmental Pollutants Antibiotic Bacterial PDI
Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic PDI
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum aminoglycoside Antibiotic with bactericidal activity against Gram-positive cocci, Gram-negative cocci, bacilli, and drug-resistant strains. Ribostamycin sulfate also acts as an inhibitor of protein disulfide isomerase (PDI), with a binding constant K_D of 319 μM for bovine PDI. Ribostamycin sulfate targets bacterial 16S ribosomal RNA and the 30S ribosomal subunit, causing translational misreading and thereby inhibiting bacterial protein synthesis. Ribostamycin sulfate disrupts the integrity of bacterial cell membranes, induces membrane pore formation, and leads to bacterial death. Ribostamycin sulfate can be used in studies related to bacterial infections .

Mudanpioside C	Structural Classification Other Monoterpenes Monophenols other families Classification of Application Fields Terpenoids Other Diseases Phenols Plants Disease Research Fields Source Classification	PDI
Mudanpioside C is a protein disulfide isomerase (PDI) inhibitor with a human IC₅₀ of 3.31 μM and human K_d of 3.9 μM. Mudanpioside C suppresses collagen-induced platelet aggregation, interferes with platelet activation, adhesion, and spreading. Mudanpioside C can be used for the research of cardiovascular diseases .

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Structural Classification Animals Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)
4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

Dicentrinone	Structural Classification Alkaloids Duguetia surinamensis R.E.Fr. Quinoline Alkaloids Plants Annonaceae Source Classification	PDI
Dicentrinone is an orally active PDI inhibitor with an IC₅₀ value of 43.95 μM. Dicentrinone directly binds to PDI and suppresses cell proliferation and reduces cancer cell viability. Dicentrinone elicits anti-inflammatory and antioxidant effects by suppressing leukocyte migration, plasma leakage and paw edema, and scavenging free radicals. Dicentrinone can be used in the research of hepatoma, rheumatism and arthritis .

Cat. No.	Product Name		Classification

HY-100433

PACMA 31 5 Publications Verification		Alkynes
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-117570

KSC-34		Alkynes
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC₅₀ of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family . KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Protein Disulfide Isomerases

Inhibitors & Agonists

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