Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
RNA building block
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "RNA building block" in MCE Product Catalog:
Research Areas:
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .
Cat. No.: HY-W141394
CAS No.: 85079-00-1
Synonyms: N-Benzoyl-2′-O-methyladenosine
Research Areas:
Bz-OMe-rA (N-Benzoyl-2′-O-methyladenosine) is a nucleoside analog with an N-benzoyl protecting group and a 2'-O-methyladenosine phosphoramidite unit. Bz-OMe-rA serves as a starting material for the chemical synthesis of the 5'-terminal cap structure of cytoplasmic polyhedrosis virus mRNA and also acts as a building block for solid-phase RNA oligonucleotide synthesis .
Cat. No.: HY-147338
CAS No.: 327174-86-7
Synonyms: 5-Methyl-CTP
Target:
Research Areas:
5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) is a modified ribonucleoside 5′-triphosphate. When incorporated into mRNA, 5-Methylcytidine 5′-triphosphate enhances the translation efficiency and stability of the mRNA, and reduces the innate immune response. 5-Methylcytidine 5′-triphosphate can be used in studies related to gene replacement and vaccination applications .
Cat. No.: HY-151829
CAS No.: 2616562-74-2
Target:
Research Areas:
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Cat. No.: HY-W892781
CAS No.: 325683-93-0
Target:
Research Areas:
DMTr-TNA A(Bz)-amidite is a nucleoside building block that has been used in the synthesis of oligonucleotides for the study of prebiotic RNA evolution .
Cat. No.: HY-17653
CAS No.: 2243974-80-1
Target:
Research Areas:
Morpholino A phosphoramidite is a specialized chemical building block used to synthesize Phosphorodiamidate Morpholino Oligomers (PMOs). Morpholino A phosphoramidite contains the adenine (A) nucleobase attached to a morpholine ring, fitted with a phosphoramidite group. PMOs are synthetic gene knockdown tools heavily used in developmental biology and targeted therapeutics to inhibit gene expression or alter RNA splicing .
Cat. No.: HY-W003943
CAS No.: 903899-13-8
Target:
Research Areas:
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block, which can be used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors .
Cat. No.: HY-188039
Target:
Research Areas:
2'-OMe-VPTm Phosphoramidite is a 2'-O-methylthymidine phosphoramidite monomer that can be used as a building block in oligonucleotide synthesis to introduce 2'-O-methyl-modified thymidine residues. 2'-OMe-VPTm Phosphoramidite can be used in RNA modification and nucleic acid chemistry research.
Cat. No.: HY-188038
Target:
Research Areas:
2'-OMe-VPGm (N-dmf) Phosphoramidite is a 2'-O-methylguanosine phosphoramidite monomer that can be used as a building block in oligonucleotide synthesis to introduce 2'-O-methyl-modified guanosine residues. 2'-OMe-VPGm (N-dmf) Phosphoramidite can be used in RNA modification and nucleic acid chemistry research.
Cat. No.: HY-W1143328
CAS No.: 1120329-56-7
Target:
Research Areas:
UNA-C(Ac)-CE Phosphoramidite is a modified RNA building block used in automated oligonucleotide synthesis. UNA-C(Ac)-CE Phosphoramidite incorporates an acyclic "Unlocked Nucleic Acid" (UNA) cytosine monomer with an acetyl (Ac) protecting group on the base and a cyanoethyl (CE) group on the phosphoramidite
Cat. No.: HY-188070
Target:
Research Areas:
C(OMe)G(OMe) Phosphoramidite is a nucleic acid phosphoramidite building block containing a methoxy-modified C-G dinucleotide unit. C(OMe)G(OMe) Phosphoramidite can be used to introduce a C(OMe)-G(OMe) dinucleotide unit during oligonucleotide synthesis and is suitable for modified oligonucleotide and RNA synthesis research.
Cat. No.: HY-188069
Target:
Research Areas:
C(F)U(OMe) Phosphoramidite is a dinucleotide phosphoramidite building block containing 2'-F and 2'-OMe modifications for introducing a C(F)-U(OMe) dinucleotide unit during oligonucleotide synthesis. C(F)U(OMe) Phosphoramidite can be used for modified oligonucleotide synthesis, RNA synthesis, and nucleic acid structure-function studies.
Cat. No.: HY-188040
CAS No.: 1953146-88-7
Target:
Research Areas:
2'-OPEG(N-TFA)-rG(N-iBu) Phosphoramidite is a 2'-OPEG-modified guanosine phosphoramidite containing an N-TFA-protected PEG functionality and an N-isobutyryl (N-iBu)-protected guanine nucleobase. It is a modified RNA phosphoramidite building block suitable for incorporating a 2'-OPEG-modified guanosine unit into oligonucleotides during phosphoramidite-based synthesis.
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
