2 Results for "

RpoC

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "RpoC" in MCE Product Catalog:

Art. -Nr.: HY-125442
CAS. Nr.: 152340-22-2
Target:  

Bacterial

Forschungsgebiete:  

Infection

Salinamide A is a bacterial RNA polymerase inhibitor with IC50: 0.2 μM against Staphylococcus aureus; 0.2 μM against Escherichia coli. Salinamide A inhibits transcription initiation and elongation, as well as bacterial RNA and protein synthesis without affecting DNA synthesis. Salinamide A can be used in studies related to the N-terminal hinge conformation and function of the RNAP bridge helix, and bacterial infections .
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Art. -Nr.: HY-N21879
CAS. Nr.: 88192-99-8
Myxopyronin B is an α-pyrone natural product derived from Myxococcus fulvus and acts as an inhibitor of the switch region of bacterial RNA polymerase (RNAP) (IC50 = 24 μM). Myxopyronin B binds to the switch region of RNA polymerase, locking the polymerase clamp into a closed conformation and thereby inhibiting transcription initiation. Myxopyronin B exhibits antibacterial activity against Staphylococcus aureus and Clostridioides difficile, inhibits the early synthesis of toxins A and B, and reduces the abundance of proteins in the branched-chain amino acid fermentation pathway. Myxopyronin B is useful for research related to bacterial infections .
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