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SARS-CoV-2 spike S1 RBD

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By Targets:	SARS-CoV (2) Angiotensin-converting Enzyme (ACE) (1) Influenza Virus (1)
By Research Areas:	Infection (2)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Targets Recommended: SARS-CoV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P991491

VIR-7229	SARS-CoV Influenza Virus	Infection
VIR-7229 is a human IgG1 monoclonal antibody (mAb) targeting *Receptor-Binding Domain, RBD, Spike* glycoprotein*. VIR-7229 exerts antiviral activity by competing with ACE2 for binding and inducing S1 protein shedding. VIR-7229 can be used in SARS-CoV-2* infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-181066

ACE2-SP PPI-IN-1	Angiotensin-converting Enzyme (ACE) SARS-CoV	Infection
ACE2-SP PPI-IN-1 is an inhibitor of the interaction between the SARS-CoV-2 spike protein and ACE2, with an IC₅₀ of 2162.77 nM. ACE2-SP PPI-IN-1 exhibits low cytotoxicity in human fibroblasts. ACE2-SP PPI-IN-1 binds to the interface region between the spike protein RBD and ACE2, reducing the flexibility of the critical receptor-binding loop and maintaining the structural compactness of the spike protein. ACE2-SP PPI-IN-1 can be used for research related to SARS-CoV-2 .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991491

VIR-7229	SARS-CoV Influenza Virus	Infection
VIR-7229 is a human IgG1 monoclonal antibody (mAb) targeting *Receptor-Binding Domain, RBD, Spike* glycoprotein*. VIR-7229 exerts antiviral activity by competing with ACE2 for binding and inducing S1 protein shedding. VIR-7229 can be used in SARS-CoV-2* infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

Species:	Virus (6)
Tag:	His (3) Tag Free (1) Avi (1) Fc (2)
Source:	HEK293 (5) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7436

	SARS-CoV-2 S1 Protein (HEK293) 2 Publications Verification 2019-nCoV RBD Protein; 2019-nCoV spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	HEK293
	SARS-CoV-2 S1 Protein (HEK293) is the recombinant S1 protein produced in HEK293 cells.

HY-P7434

	SARS-CoV-2 S1 Protein (HEK293, mFc) 2019-nCoV RBD Protein; 2019-nCoV spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	HEK293
	SARS-CoV-2 S1 Protein (HEK293, mFc) is the recombinant 2019-nCoV S1 protein with C-mFc tag produced in HEK293 cells.

HY-P73409

	SARS-CoV-2 S1 Protein (HEK293, His) 2019-nCoV RBD Protein; 2019-nCoV spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	HEK293
	The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S1 Protein (HEK293, His) is the recombinant Virus-derived SARS-CoV-2 S1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7435

	SARS-CoV-2 S1 Protein (HEK293, Fc) 2019-nCoV RBD Protein; 2019-nCoV spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	HEK293
	SARS-CoV-2 S1 Protein (HEK293, Fc) is the recombinant 2019-nCoV S1 protein with C-Fc tag produced in HEK293 cells.

HY-P73408

	SARS-CoV-2 S1 Protein (sf9, His) 2019-nCoV RBD Protein; 2019-nCoV spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	Sf9 insect cells
	The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S1 Protein (sf9, His) is the recombinant Virus-derived SARS-CoV-2 S1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P77191

	SARS-CoV-2 S1 Protein (Biotinylated, HEK293, Avi-His) 2019-nCoV RBD Protein; 2019-nCoV spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD	Virus	HEK293
	The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S1 Protein (Biotinylated, HEK293, Avi-His) is the recombinant Virus-derived SARS-CoV-2 S1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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