5 Results for "

SIRT1-AMPK

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "SIRT1-AMPK" in MCE Product Catalog:

10
10,12-Tricosadiynoic acid
10,12-Tricosadiynoic acid
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10 Publications Verification
Cat. No.: HY-135425
CAS No.: 66990-30-5
Purity:  99.05%
Target:  

Acyltransferase

Research Areas:  

Metabolic Disease

10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism [1]. 10,12-Tricosadiynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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(+)-Magnoflorine chloride
(+)-Magnoflorine chloride
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1 Cited Publications
Cat. No.: HY-N0535
CAS No.: 6681-18-1
Synonyms: Magnoflorine chloride; α-Magnoflorine chloride; Thalictrine chloride
Category:  

Metabolic Disease Plants Aristolochiaceae Infection Alkaloids Piperidine Alkaloids other families Aristolochia debilis Sieb. et Zucc. Phenols Polyphenols Disease Research Fields

Target:  

Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)

(+)-Magnoflorine (α-Magnoflorine) chloride is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine chloride promotes Parkin/PINK1-mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine chloride inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine chloride upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine chloride also has significant antifungal activity [1] .
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(+)-Magnoflorine iodide
(+)-Magnoflorine iodide
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1 Cited Publications
Cat. No.: HY-N0334A
CAS No.: 4277-43-4
Synonyms: Magnoflorine iodide; α-Magnoflorine iodide; Thalictrine iodide
Category:  

Alkaloids Magnoliaceae Metabolic Disease Phenols Polyphenols Magnolia Liliflora Desr. Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)

(+)-Magnoflorine (α-Magnoflorine) iodide is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine iodide promotes Parkin/PINK1 -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine iodide inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine iodide also has significant antifungal activity [1] .
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(+)-Magnoflorine
(+)-Magnoflorine
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Cat. No.: HY-N0334
CAS No.: 2141-09-5
Synonyms: Magnoflorine; α-Magnoflorine; Thalictrine
Category:  

Alkaloids Ranunculaceae Coptis chinensis Franch. Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)

(+)-Magnoflorine (α-Magnoflorine) is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine promotes Parkin/PINK1 -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine also has significant antifungal activity [1] .
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Arjunolic acid
Arjunolic acid
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Cat. No.: HY-N2896
CAS No.: 465-00-9
Category:  

Triterpenes Juglandaceae Terpenoids Cyclocarya paliurus (Batal.) Iljinsk. Plants Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers Reactive Oxygen Species (ROS) Apoptosis Fungal Bacterial NF-κB SOD AMPK mTOR Notch Toll-like Receptor (TLR) Wnt MyD88 Sirtuin

Arjunolic acid is an orally active, multifunctional bioactive compound. Arjunolic acid exhibits free radical scavenging activity, as well as fungal and bacterial activities. Arjunolic acid induces apoptosis (Apoptosis) in various cancer cells. Arjunolic acid protects hepatocytes against induced oxidative stress and apoptosis by reducing reactive oxygen species and inhibiting NF-κB activation. Arjunolic acid regulates pancreatic dysfunction in type 2 diabetic rats by blocking the activation of the TLR-4/MyD88 and canonical Wnt pathways. Arjunolic acid inhibits neuroinflammation and ameliorates depressive behaviors via the SIRT1/AMPK/Notch1 signaling pathway in microglia. Arjunolic acid improves Crohn's disease-like colitis by restoring gut microbiota composition and inhibiting TLR4 signaling. Arjunolic acid suppresses osteosarcoma progression by inhibiting Wnt3a-mediated M2 polarization of macrophages. Arjunolic acid ameliorates diabetic retinopathy via the autophagy pathway regulated by AMPK/mTOR/HO-1. Arjunolic acid is applicable to research related to type 2 diabetes, organ toxicity, depression, Crohn's disease, osteosarcoma, diabetic retinopathy, and testicular dysfunction [1] .
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