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Siegesbeckia

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By Targets:	Akt (1) AMPK (1) Apoptosis (1) Casein Kinase (1) COX (1) Interleukin Related (1) NF-κB (2) Reference Standards (2) TGF-beta/Smad (1) TNF Receptor (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6028

Darutoside 1 Publications Verification	COX NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Darutoside is an orally effective diterpene compound with significant anti-inflammatory, analgesic, wound healing promotion, and immunomodulatory activities. Darutoside reduces edema and pain responses by inhibiting the expression of COX-2 and the migration of inflammatory cells. It regulates macrophage polarization towards the M2 type by inhibiting the NF-κB pathway, alleviating inflammation and promoting wound healing. Through multi-target regulation of metabolic networks, Darutoside significantly alleviates acute gouty arthritis .

HY-N1496

15,16-Di-O-acetyldarutoside	Others	Others
15,16-Di-O-acetyldarutoside (compound 5) is an ent-pimarane diterpenoid compound isolated from the ethanol extract of Siegesbeckia orientalis .

HY-N4245

Siegesmethyletheric acid	Others	Others
Siegesmethyletheric acid is isolated from the ethyl acetate fraction of Siegesbeckia orientalis L. (Asteraceae) .

HY-N11547

Leocarpinolide F	Others	Others
Leocarpinolide F is a natural sesquiterpenoid that can be isolated from Siegesbeckia orientalis .

HY-N3972

Grandifloric acid	Others	Others
Grandifloric acid is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis L. .

HY-N6028R

Darutoside (Standard)	Reference Standards	Inflammation/Immunology
Darutoside (Standard) is the analytical standard of Darutoside. This product is intended for research and analytical applications. Darutoside is a diterpenoid isolated from Siegesbeckia .

HY-N0559R

Kirenol (Standard)	Reference Standards Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Kirenol (Standard) is the analytical standard of Kirenol (HY-N0559). This product is intended for research and analytical applications. Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis.

HY-N3812

ent-14,16-Epoxy-8-pimarene-3,15-diol	Others	Others
ent-14,16-Epoxy-8-pimarene-3,15-diol is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis .

HY-N3814

ent-16β,17-Dihydroxykauran-19-oic acid	Others	Inflammation/Immunology
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

HY-N19943

Siegeside B	Others	Cancer
Siegeside B is a diterpenoid glycoside found in the dried aerial parts of Siegesbeckia pubescens. Siegeside B inhibits epidermal growth factor-induced migration and invasion of breast cancer cells. Siegeside B can be used for the research of breast cancer .

HY-N2751

7-Hydroxydarutigenol	Others	Others
7-Hydroxydarutigenol is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis .

HY-N1603

16-o-Acetyldarutigenol	Others	Others
16-o-Acetyldarutigenol (compound 4) is an ent-pimarane diterpenoid compound isolated from the ethanol extract of Siegesbeckia orientalis .

Darutoside 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Diterpenoids Plants Compositae Tephrosia candida DC. Inflammation/Immunology Disease Research Fields Source Classification	COX NF-κB Interleukin Related TNF Receptor
Darutoside is an orally effective diterpene compound with significant anti-inflammatory, analgesic, wound healing promotion, and immunomodulatory activities. Darutoside reduces edema and pain responses by inhibiting the expression of COX-2 and the migration of inflammatory cells. It regulates macrophage polarization towards the M2 type by inhibiting the NF-κB pathway, alleviating inflammation and promoting wound healing. Through multi-target regulation of metabolic networks, Darutoside significantly alleviates acute gouty arthritis .

Siegesmethyletheric acid	Classification of Application Fields Ketones, Aldehydes, Acids Bituminaria morisiana (Pignatti & Metlesics) Greuter Other Diseases Plants Compositae Disease Research Fields Source Classification	Others
Siegesmethyletheric acid is isolated from the ethyl acetate fraction of Siegesbeckia orientalis L. (Asteraceae) .

Leocarpinolide F	Terpenoids Sesquiterpenes Bituminaria morisiana (Pignatti & Metlesics) Greuter Plants Compositae Source Classification	Others
Leocarpinolide F is a natural sesquiterpenoid that can be isolated from Siegesbeckia orientalis .

Grandifloric acid	Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Others
Grandifloric acid is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis L. .

Darutoside (Standard)	Structural Classification Terpenoids Diterpenoids Plants Compositae Tephrosia candida DC. Source Classification	Reference Standards
Darutoside (Standard) is the analytical standard of Darutoside. This product is intended for research and analytical applications. Darutoside is a diterpenoid isolated from Siegesbeckia .

Kirenol (Standard)	Structural Classification Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Reference Standards Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad
Kirenol (Standard) is the analytical standard of Kirenol (HY-N0559). This product is intended for research and analytical applications. Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis.

ent-14,16-Epoxy-8-pimarene-3,15-diol	Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Others
ent-14,16-Epoxy-8-pimarene-3,15-diol is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis .

ent-16β,17-Dihydroxykauran-19-oic acid	Terpenoids Diterpenoids Plants Compositae Tephrosia candida DC. Source Classification	Others
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

Siegeside B	Structural Classification Terpenoids Diterpenoids Plants Compositae Tephrosia candida DC. Source Classification	Others
Siegeside B is a diterpenoid glycoside found in the dried aerial parts of Siegesbeckia pubescens. Siegeside B inhibits epidermal growth factor-induced migration and invasion of breast cancer cells. Siegeside B can be used for the research of breast cancer .

7-Hydroxydarutigenol	Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Others
7-Hydroxydarutigenol is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Siegesbeckia

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