Bituminaria morisiana (Pignatti & Metlesics) Greuter

Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis.

8-Prenyldaidzein is an isoflavonoid, that can be isolated from Bituminaria morisiana. 8-Prenyldaidzein shows antioxidant activity.

Isopropylidenekirenol is a natural diterpene.

Kirenol (Standard) is the analytical standard of Kirenol (HY-N0559). This product is intended for research and analytical applications. Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis.

(2E)-Leocarpinolide F (Compound 20), a germacrane-type sesquiterpenoid, can be isolated from Sigesbeckia orientalis.

17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene is a natural sesquiterpene lactone with anti-inflammatory activity.

Anti-osteoporosis agent-2 (Compound 10) is an anti-osteoporosis agent. Anti-osteoporosis agent-2 inhibits differentiation on osteoclast induced by RANKL.

Deacetylorientalide (compound 19) is a germacrane-type sesquiterpenoid compound that can be found in from Sigesbeckia orientalis.

Leocarpinolide F is a natural sesquiterpenoid that can be isolated from Siegesbeckia orientalis.

Hythiemoside A is found in Sigesbeckia orientalis L.

Siegesmethyletheric acid is isolated from the ethyl acetate fraction of Siegesbeckia orientalis L. (Asteraceae).

Darutigenol is an ent-pimarane-type diterpenoid isolated from Siegesbecikia orientalis L..

Pubetallin is a germacrane-type sesquiterpenoid (germacranolide) can be found in the aerial parts of Sigesbeckia orientalis. Pubetallin induces cytotoxicity in breast cancer cells. Pubetallin can be used for the research of breast cancer.

yfj is a natural product.

Grandifloric acid is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis L..

ent-14,16-Epoxy-8-pimarene-3,15-diol is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis.

7-Hydroxydarutigenol is a Diterpenoids product that can be isolated from the herbs of Siegesbeckia orientalis.

ent-Kauran-17,19-dioic acid (16α-Hydro-ent-kauran-17,19-dioic acid) is an ent-kaurane diterpenoid.