1 Result for "

Sophocarpine (Standard)

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Sophocarpine (Standard)" in MCE Product Catalog:

Sophocarpine (Standard)
Sophocarpine (Standard)
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Cat. No.: HY-N0103R
CAS No.: 6483-15-4
Category:  

Alkaloids Piperidine Alkaloids Leguminosae Plants Sophora flavescens Aiton

Target:  

Reference Standards Autophagy Apoptosis NF-κB PI3K Akt MEK ERK

Sophocarpine (Standard) is the analytical standard of Sophocarpine (HY-N0103). This product is intended for research and analytical applications. Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage .
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