3 Results for "

Tetrahydrocolumbamine

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Tetrahydrocolumbamine" in MCE Product Catalog:

Cat. No.: HY-N0927
CAS No.: 483-34-1
Synonyms: Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine
(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research .
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Cat. No.: HY-N0927A
CAS No.: 53447-14-6
Synonyms: (R)-Tetrahydrocolumbamine
(+)-Isocorypalmine can be found in Corydalis cava (L.) SCHW. et KOERTE .
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Cat. No.: HY-E71115
Research Areas:  

Others

(S)-Canadine synthase (EC 1.14.21.5) catalysing an oxidative reaction that does not incorporate oxygen into the product. Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine.
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