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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
Tubulin degrader1
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "Tubulin degrader1" in MCE Product Catalog:
Cat. No.: HY-161324
Target:
Research Areas:
Tubulin degrader 1, a derivative of BML284 (HY-19987), is an orally active Tubulin degrader with anti-tumor cell proliferation activity. Tubulin degrader 1 binds to the colchicine-binding site of β-tubulin, inhibits tubulin polymerization and promotes tubulin degradation. Tubulin degrader 1 inhibits microtubule polymerization, induces G2/M cell cycle arrest and apoptosis. Tubulin degrader 1 suppresses tumor growth in ovarian cancer xenograft models, induces anti-proliferative activity against tumor cells and overcomes multidrug resistance. Tubulin degrader 1 can be used in research related to various cancers including ovarian cancer .
Cat. No.: HY-162098
Target:
Research Areas:
PROTAC tubulin-Degrader-1 is a α/β/β3-tubulin PROTAC degrader. PROTAC tubulin-Degrader-1 exhibits potent anti-proliferative activity against multiple human tumor cell lines. PROTAC tubulin-Degrader-1 induces G2/M phase arrest and apoptosis and inhibits colony formation in A549 and A549/Taxol cells. PROTAC tubulin-Degrader-1demonstrates potent anti-tumor efficacy in A549 and A549/Taxol (Taxol-resistant) xenograft model. PROTAC tubulin-Degrader-1 can be used for the study of non-small cell lung cancer (NSCLC). (Pink: Tubulin ligand (HY-N2146), Blue: CRBN Ligand (HY-10984), Black: Linker (HY-N6056)) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
