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Results for "

Venom

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenylate Cyclase (1) Adrenergic Receptor (1) Akt (3) Amylases (1) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (1) AP-1 (1) Apoptosis (10) Atg8/LC3 (2) Autophagy (2) Bacterial (19) Biochemical Assay Reagents (6) Calcium Channel (11) Caspase (2) CDK (1) Chloride Channel (3) Cholinesterase (ChE) (2) Complement System (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (1) Drug Derivative (1) Endogenous Metabolite (6) ERK (1) Factor Xa (4) FAP (1) Fluorescent Dye (3) Fungal (5) GABA Receptor (6) GCGR (3) GLP Receptor (1) Glutamate Dehydrogenase (GLDH) (2) Glycosidase (1) GSK-3 (1) Histamine Receptor (2) iGluR (1) Insecticide (1) Integrin (4) Interleukin Related (2) Isotope-Labeled Compounds (1) JNK (1) Mitochondrial Metabolism (1) Monocarboxylate Transporter (1) mTOR (2) nAChR (2) Necroptosis (1) NF-κB (2) P2X Receptor (1) p38 MAPK (1) PARP (2) Peptide-Drug Conjugates (PDCs) (1) Phosphatase (1) Phosphodiesterase (PDE) (4) Phospholipase (8) PI3K (3) Piezo Channel (2) Potassium Channel (24) Reactive Oxygen Species (ROS) (1) Reference Standards (4) Ser/Thr Protease (1) Sodium Channel (22) TNF Receptor (1) TRP Channel (2) Tyrosinase (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (21) Endocrinology (2) Infection (27) Inflammation/Immunology (27) Metabolic Disease (12) Neurological Disease (59)

By Targets:

5-HT Receptor (1)

Adenylate Cyclase (1)

Adrenergic Receptor (1)

Akt (3)

Amylases (1)

Angiotensin Receptor (1)

Angiotensin-converting Enzyme (ACE) (1)

AP-1 (1)

Apoptosis (10)

Atg8/LC3 (2)

Autophagy (2)

Bacterial (19)

Biochemical Assay Reagents (6)

Calcium Channel (11)

Caspase (2)

CDK (1)

Chloride Channel (3)

Cholinesterase (ChE) (2)

Complement System (1)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Endogenous Metabolite (6)

ERK (1)

Factor Xa (4)

FAP (1)

Fluorescent Dye (3)

Fungal (5)

GABA Receptor (6)

GCGR (3)

GLP Receptor (1)

Glutamate Dehydrogenase (GLDH) (2)

Glycosidase (1)

GSK-3 (1)

Histamine Receptor (2)

iGluR (1)

Insecticide (1)

Integrin (4)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

JNK (1)

Mitochondrial Metabolism (1)

Monocarboxylate Transporter (1)

mTOR (2)

nAChR (2)

Necroptosis (1)

NF-κB (2)

P2X Receptor (1)

p38 MAPK (1)

PARP (2)

Peptide-Drug Conjugates (PDCs) (1)

Phosphatase (1)

Phosphodiesterase (PDE) (4)

Phospholipase (8)

PI3K (3)

Piezo Channel (2)

Potassium Channel (24)

Reactive Oxygen Species (ROS) (1)

Reference Standards (4)

Ser/Thr Protease (1)

Sodium Channel (22)

TNF Receptor (1)

TRP Channel (2)

Tyrosinase (1)

By Research Areas:

Cancer (22)

Cardiovascular Disease (21)

Endocrinology (2)

Infection (27)

Inflammation/Immunology (27)

Metabolic Disease (12)

Neurological Disease (59)

153

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

118

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1902

Cardiotoxin Analog (CTX) IV (6-12) 5+ Cited Publications	Apoptosis	Cardiovascular Disease
Cardiotoxin Analog (CTX) IV (6-12) is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .

HY-P0256

Apamin 5+ Cited Publications Apamine	Potassium Channel	Neurological Disease Inflammation/Immunology
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca ²⁺-activated K ⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .

HY-P0173A

Chlorotoxin 2 Publications Verification	Chloride Channel	Cancer
Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.

HY-NP004

*Cobra Venom* Factor** CVF	Complement System	Inflammation/Immunology
Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.) .

HY-P1902A

Cardiotoxin Analog (CTX) IV (6-12) TFA 5+ Cited Publications	Apoptosis	Cardiovascular Disease
Cardiotoxin Analog (CTX) IV (6-12) TFA is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) TFA was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) TFA is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) TFA can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .

HY-P3029A

Phospholipase A2, Crotalus adamanteus Venom PLA2, Crotalus adamanteus Venom	Phospholipase	Others
Phospholipase A2, Crotalus adamanteus Venom (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2, Crotalus adamanteus Venom is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies .

HY-P0246

Mastoparan	Endogenous Metabolite	Metabolic Disease
Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells.

HY-P0173B

Chlorotoxin TFA 2 Publications Verification	Chloride Channel	Cancer
Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker . Anti-cancer activity .

HY-12537

Peptide 401	Histamine Receptor 5-HT Receptor	Inflammation/Immunology Endocrinology
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

HY-P3914

Cecropin A (1-7)-Melittin A (2-9) Oct-CA(1-7)M(2-9)	Bacterial	Infection
Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides .

HY-P1443

OD1	Sodium Channel	Cancer
OD1 is a scorpion α-toxin that can be isolated from the venom of the Iranian yellow scorpion (Odonthobuthus doriae. OD1 is a modulator of mammalian Nav1.7 (EC₅₀: 4.5 nM) .

HY-P3985

Bradykinin potentiator B Bradykinin potentiating peptide B	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Others
Bradykinin potentiator B (Bradykinin potentiating peptide B) is venom of Agkistrodon halys blomhoffi. Bradykinin potentiator B is a potent ACE inhibitor. Bradykinin potentiator inhibits the activity of bradykinin inhibitory peptidase .

HY-W013741

CME-carbodiimide	Biochemical Assay Reagents DNA Alkylator/Crosslinker DNA/RNA Synthesis	Others
CME-carbodiimide is a nucleic acid modification reagent. CME-carbodiimide reacts specifically with uracil and guanine residues of RNA, as well as guanine and thymine residues of denatured DNA; it does not react with native DNA. Modification of DNA by CME-carbodiimide inhibits phosphodiester bond cleavage or DNA hydrolysis mediated by pancreatic ribonuclease, snake venom phosphodiesterase and deoxyribonuclease .

HY-P2705

Mastoparan X	Endogenous Metabolite	Others
Mastoparan X is a GTP-binding regulatory protein (G protein)-activating peptide, and a tetradecapeptide from wasp venom. Mastoparan X acts function by the direct activation of G protein that couple to phospholipase C to cause secretion from various kinds of cells .

HY-P3269

Calciseptine	Calcium Channel	Cardiovascular Disease
Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis). Calciseptine is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC₅₀ value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases_[1].

HY-P3095

α-Latrotoxin	Endogenous Metabolite	Neurological Disease
α-Latrotoxin, a potent neurotoxin from black widow spider venom, triggers synaptic vesicle exocytosis from presynaptic nerve terminals .

HY-P5152

Scorpion toxin Tf2	Sodium Channel	Neurological Disease
Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials .

HY-P3037A

Imperatoxin A TFA	Calcium Channel	Neurological Disease
Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. Imperatoxin A TFA is a Ca ²⁺-release channels/ryanodine receptors (RyRs) activator. Imperatoxin A TFA enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-W012479S

H-D-Trp-OH-d5 D-Tryptophan-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
H-D-Trp-OH-d₅ (D-Tryptophan-d₅) is the deuterium labeled H-D-Trp-OH. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.

HY-P2878A

Phosphodiesterase l, Rattlesnake venom PDE, Rattlesnake Venom	Phosphodiesterase (PDE)	Metabolic Disease
Phosphodiesterase l, Rattlesnake venom (PDE, Rattlesnake venom) is a non-selective phosphodiester bond hydrolase targeting phosphodiester bonds in oligonucleotides, catalyzing their hydrolysis into mononucleotides. Phosphodiesterase l, Rattlesnake venom cleaves phosphodiester linkages in DNA fragments digested by DNase I. Phosphodiesterase l, Rattlesnake venom is promising for research of nucleic acid structure and metabolism .

HY-P5652

Bombolitin II	Bacterial	Infection
Bombolitin II is an antimicrobial peptide derived from bumblebee venom. Bombolitin II can lysate erythrocyte and liposome .

HY-P5781

δ-Theraphotoxin-Hm1b	Sodium Channel	Neurological Disease
δ-Theraphotoxin-Hm1b is a 42-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. δ-Theraphotoxin-Hm1b selectively inhibits inactivation of NaV1.1 but have no effect on NaV1.7 .

HY-P1441

Mambalgin 1	Sodium Channel	Others
Mambalgin-1 is a toxin isolated from black mamba venom. Mambalgin-1 is a disulfide-rich polypeptide consisting of 57 amino acids and belongs to the family of three-finger toxins. Mambalgin-1 can bind to and stabilize ASICs (acid-sensing ion channels) in a physiologically relevant closed-channel conformation .

HY-P10518

Anoplin	Bacterial	Infection
Anoplin is an antimicrobial peptide found in the venom of the solitary wasp (Anoplius samariensis). Anoplin exhibits antimicrobial activity against a wide range of bacteria, including both gram-positive and gram-negative bacteria. Anoplin can be used in the development of antibiotics .

HY-P5159

Crotamine	Sodium Channel	Inflammation/Immunology
Crotamine is a Na ⁺ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom .

HY-P5159A

Crotamine TFA	Sodium Channel	Inflammation/Immunology
Crotamine TFA is a Na ⁺ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom .

HY-P11193

Scolopin-2	Bacterial Fungal	Infection
Scolopin-2 is an antimicrobial peptide that can be isolated from centipede venoms. Scolopin-2 shows strong antimicrobial activities against a panel of Gram-positive/negative bacteria and fungi (MIC ≤ 7.5 μg/mL) . Scolopin-2 shows moderate hemolytic activity against both human and rabbit red cells. Scolopin-2 can be used for antimicrobial research .

HY-P3009D

Rat Factor Xa	Factor Xa	Cardiovascular Disease
Rat Factor Xa is prepared by activating purified Rat Factor X with Russells' Viper Venom, after which the Russells' Viper Venom is removed.

HY-P3009C

Rabbit Factor Xa	Factor Xa	Cardiovascular Disease
Rabbit Factor Xa is prepared by activating purified Rabbit Factor X with Russells' Viper Venom, after which the Russells' Viper Venom is removed.

HY-P3009A

Canine Factor Xa	Factor Xa	Cardiovascular Disease
Canine Factor Xa is prepared by activating purified Canine Factor X with Russells' Viper Venom, after which the Russells' Viper Venom is removed.

HY-P3009B

Porcine Factor Xa	Factor Xa	Cardiovascular Disease
Porcine Factor Xa is prepared by activating purified Porcine Factor X with Russells' Viper Venom, after which the Russells' Viper Venom is removed.

HY-N0879

Pseudobufarenogin ψ-Bufarenogin	Others	Cancer
Pseudobufarenogin (ψ-Bufarenogin) is an extract of toad venom with an unknown activity background.

HY-P1543

Exendin-3	GLP Receptor Amylases GCGR	Neurological Disease
Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn.

HY-N4255

Resibufagin	Others	Cancer
Resibufagin is a kind of bufadienolide isolated from the venom of Bufo bufo gargarizans, has anti-tumor activities .

HY-P4071

OH-CATH Cathelicidin-OH antimicrobial peptide	Bacterial	Infection
OH-CATH is a natural antimicrobial peptide that can be isolated from the venom and tissue of Ophiophagus hannah (King Cobra) .

HY-P1084

β-Pompilidotoxin β-PMTX	Sodium Channel	Neurological Disease
β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells .

HY-P3065

Calcicludine	Calcium Channel	Neurological Disease
Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated calcium channel, especially L-type calcium channel .

HY-P5833

κ-Bungarotoxin κ-Bgt	nAChR	Neurological Disease
κ-Bungarotoxin (κ-Bgt) is a potent, selective, and slowly reversible antagonist of α3β2 neuronal nicotinic acetylcholine receptors with an IC₅₀ of 2.30 nM .

HY-P2619

BPP 5a	Angiotensin Receptor Peptide-Drug Conjugates (PDCs)	Cardiovascular Disease
BPP 5a is a bradykinin-potentiating peptide with vasorelaxant activity, which is found in Bothrops jararaca venom. BPP 5a is an angiotensin-converting enzyme (ACE) inhibitor with a K_i value of 400 nM. BPP 5a is promising for research of hypertension and cardiovascular diseases .

HY-P0256A

Apamin TFA 5+ Cited Publications Apamine TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca ²⁺-activated K ⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .

HY-P3050

Helospectin II	GCGR	Cardiovascular Disease
Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum .

HY-P5653

Bombolitin III	Bacterial	Infection
Bombolitin III is an antimicrobial peptide derived from bumblebee venom. Bombolitin III can lysate erythrocyte and liposome .

HY-P5654

Bombolitin IV	Bacterial	Infection
Bombolitin IV is an antimicrobial peptide derived from bumblebee venom. Bombolitin IV can lysate erythrocyte and liposome .

HY-P5851

AaHI	Biochemical Assay Reagents	Neurological Disease
AaHI is a neurotoxin that can be obtained from the venom of the North African scorpion Androctonus australis hector. AaHI can be used as a tool for the development of active substances with toxin-neutralizing capabilities .

HY-P5835

δ-Dendrotoxin	Potassium Channel	Neurological Disease
δ-Dendrotoxin is a K ⁺ channel blocker that can be obtained from the venom of the black mamba snake. δ-Dendrotoxin can be used in the study of neurological diseases .

HY-P5629

MCF	Bacterial	Infection
MCF is an antimicrobial peptide derived from bee venom. MCF has activity against E.coli W 160-37, S.aureus 8530 and B.subtilis, the MIC values are 35-45 μg/ml, 25-35 μg/ml and 15-25 μg/ml .

HY-P5780

π-TRTX-Hm3a	Sodium Channel	Neurological Disease
π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC₅₀ of 1-2 nM and potentiates ASIC1b with an EC₅₀ of 46.5 nM .

HY-P5854

Aa1 toxin	Potassium Channel	Neurological Disease
Aa1 toxin, a neurotoxic peptide that can be obtained from the venom of Androctonus australis Garzoni, is a specific potassium channel blocker. Aa1 toxin can be used in the study of neurological diseases .

HY-141555

5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione	Phosphodiesterase (PDE) Tyrosinase	Others
5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor for snake venom and human recombinant phosphodiesterase 1 with IC₅₀ of 429 and 467 μM. 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione inhibits mushroom tyrosinase weakly, with K_i of 1.9 μM .

HY-P5857

MmTx2 toxin Micrurotoxin 2	GABA Receptor	Neurological Disease
MmTx2 toxin is a GABA_A receptor modulator that enhances GABA_A receptor sensitivity to agonists. MmTx2 toxin can be obtained from venom of coral snake. MmTx2 toxin can be used in the study of neurological diseases such as epilepsy, schizophrenia and chronic pain .

Cat. No.	Product Name

HY-L220

Biotoxin Library

90 compounds

Biotoxins, also referred to as natural toxins, are chemical substances produced by plants, animals, or microorganisms that exert toxic effects on other living organisms. Due to unique biological activities, biotoxins have been widely applied in molecular biology, physiology, pharmacology, and the clinical diagnosis and treatment of various human diseases, becoming an important source of natural drug development. Biotoxins can specifically bind to and interfere with intracellular signaling molecules or receptors, thereby altering cellular signaling processes. Leveraging this characteristic, biotoxins can be used to study the regulatory mechanisms of cellular signaling pathways. For example, neurotoxins such as snake venom peptides can be used to investigate the functional regulation of neurotransmitter receptors and ion channels. Additionally, biotoxins have demonstrated significant potential in drug development across various fields, including neurological diseases, cardiovascular diseases, anticoagulation, and anti-cancer therapies. With advancements in high throughput screening, structural optimization, and antibody-toxin conjugation technologies, numerous biotoxins or their structural analogs have been successfully brought to market, such as Ziconotide, Captopril, Bivalirudin, and Eptifibatide.

MCE offers 90 types of biotoxins, including neurotoxins, cardiotoxins, mycotoxins, and more.

Cat. No.	Product Name	Type

HY-NP004

Cobra Venom Factor

CVF

Biochemical Assay Reagents

Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.) .

HY-158082B

TRITC-dextran, MW 40000

Tetramethyl rhodamine isothiocyanate glucan, MW 40000

Biochemical Assay Reagents

TRITC-dextran (Tetramethyl rhodamine isothiocyanate glucan), MW 40000 is a TRITC (HY-D0791)-labeled neutral 40 kDa fluorescent polysaccharide probe. TRITC-dextran, MW 40000 forms a membrane layer on the surface of protocells composed of protamine/folate condensates, and is used to assess membrane fluidity via fluorescence recovery after photobleaching. TRITC-dextran, MW 40000 can also be used to evaluate the anti-bacterial invasion ability and colloidal stability of coated condensates, as well as analyze the permeability of vascular and lymphatic endothelial cell layers .

HY-W013741

CME-carbodiimide

Biochemical Assay Reagents

CME-carbodiimide is a nucleic acid modification reagent. CME-carbodiimide reacts specifically with uracil and guanine residues of RNA, as well as guanine and thymine residues of denatured DNA; it does not react with native DNA. Modification of DNA by CME-carbodiimide inhibits phosphodiester bond cleavage or DNA hydrolysis mediated by pancreatic ribonuclease, snake venom phosphodiesterase and deoxyribonuclease .

HY-NP024

Snake poison protein	Biochemical Assay Reagents
Snake poison protein is a venom protein secreted by the salivary glands of venomous snakes .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992153

Serrumab	Interleukin Related	Inflammation/Immunology
Serrumab is a human monoclonal antibody that counteracts the biochemical and immunological effects of Tityus serrulatus venom. Serrumab inhibits the TsV-induced increase in the production of IL-6, TNFα and IL-10. Serrumab also prevents TsV-induced elevations in plasma urea, creatinine, aspartate transaminase and glucose levels, as well as the TsV-induced increase in neutrophil recruitment. Serrumab can be used in research related to envenoming by the Brazilian yellow scorpion .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P1902

Cardiotoxin Analog (CTX) IV (6-12) 5+ Cited Publications	Cardiovascular Disease Natural Products Animals Disease Research Fields Source Classification	Apoptosis
Cardiotoxin Analog (CTX) IV (6-12) is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .

HY-P0173A

Chlorotoxin 2 Publications Verification	Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification Cancer	Chloride Channel
Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.

HY-P0190

Iberiotoxin 2 Publications Verification	Cardiovascular Disease Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Potassium Channel
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca ²⁺-activated K ⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels .

HY-N0876

Arenobufagin 4 Publications Verification	Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Apoptosis Autophagy PI3K Akt mTOR PARP Caspase Atg8/LC3
Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway .

HY-N0815

Resibufogenin 5+ Cited Publications Bufogenin; Recibufogenin	Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	PI3K Akt NF-κB AP-1 GSK-3 CDK
Resibufogenin is an orally active anticancer agent. Resibufogenin can be extracted from toad venom. Resibufogenin blocks signaling pathways such as PI3K/Akt, NF-κB, AP-1, activates GSK-3β, and regulates cyclin D1. Resibufogenin can activate central neurons. Resibufogenin has anti-inflammatory activity. Resibufogenin has anti-tumor effects on a variety of tumors such as multiple myeloma, renal cancer, colorectal cancer, pancreatic cancer, and glioma .

HY-P1902A

Cardiotoxin Analog (CTX) IV (6-12) TFA 5+ Cited Publications	Structural Classification Pyrrole Alkaloids Animals Other Diseases Disease Research Fields Source Classification	Apoptosis
Cardiotoxin Analog (CTX) IV (6-12) TFA is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) TFA was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) TFA is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) TFA can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .

HY-P1189

Echistatin	Natural Products Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Integrin
Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and α₅β₁ .

HY-75625

2-Hydroxy-4-methoxybenzoic acid 4-Methoxysalicylic Acid	Structural Classification Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Phenols Plants Disease Research Fields Source Classification	Monocarboxylate Transporter Apoptosis Mitochondrial Metabolism
2-Hydroxy-4-methoxybenzoic acid is an orally active inhibitor of MCT-1 and MCT-4, as well as a plant biomarker. 2-Hydroxy-4-methoxybenzoic acid can be isolated from roots. 2-Hydroxy-4-methoxybenzoic acid induces Apoptosis and loss of mitochondrial membrane potential. 2-Hydroxy-4-methoxybenzoic acid exhibits anticancer activity against breast cancer. 2-Hydroxy-4-methoxybenzoic acid normalizes lactic acid levels. 2-Hydroxy-4-methoxybenzoic acid neutralizes viper venom and attenuates its lethal, hemorrhagic, coagulant and anticoagulant activities in male albino mice. 2-Hydroxy-4-methoxybenzoic acid possesses antihyperlipidemic, antidiabetic and hepatoprotective activities .

HY-P0246

Mastoparan	Natural Products Animals Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Endogenous Metabolite
Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells.

HY-P0173B

Chlorotoxin TFA 2 Publications Verification	Natural Products Classification of Application Fields Animals Disease Research Fields Cancer Source Classification	Chloride Channel
Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker . Anti-cancer activity .

HY-P1189A

Echistatin TFA	Natural Products Animals Classification of Application Fields Metabolic Disease Inflammation/Immunology Disease Research Fields Source Classification	Integrin
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and α₅β₁ .

HY-P1280

Margatoxin 1 Publications Verification	Natural Products Animals Neurological Disease Disease Research Fields Source Classification	Potassium Channel
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .

HY-N0879

Pseudobufarenogin ψ-Bufarenogin	Structural Classification Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Others
Pseudobufarenogin (ψ-Bufarenogin) is an extract of toad venom with an unknown activity background.

HY-P1543

Exendin-3	Natural Products Animals Source Classification	GLP Receptor Amylases GCGR
Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn.

HY-N4255

Resibufagin	Structural Classification Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Others
Resibufagin is a kind of bufadienolide isolated from the venom of Bufo bufo gargarizans, has anti-tumor activities .

HY-P3065

Calcicludine	Natural Products Animals Source Classification	Calcium Channel
Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated calcium channel, especially L-type calcium channel .

HY-N7017

19-Oxocinobufagin	Classification of Application Fields Animals Metabolic Disease Disease Research Fields Steroids Source Classification	Others
19-Oxocinobufagin is a bufadienolide in toad venom .

HY-N4016

Ikshusterol 3-O-glucoside	Structural Classification Urticaceae Urtica dioica L. Plants Steroids Source Classification	Phospholipase
Ikshusterol 3-O-glucoside is a phytochemical that inhibits PLA2 from snake venoms .

HY-P1987

Mast cell degranulating peptide (28-49)	Natural Products Animals Source Classification	Calcium Channel
Mast cell degranulating peptide (28-49) is a depolarizing agent from bee venom, it can raise the content of cGMP level in mouse cerebellar slices .

HY-N6575

7β-Hydroxybufalin	Classification of Application Fields Animals Cardiacglycosides Metabolic Disease Disease Research Fields Steroids Source Classification	Glycosidase Cholinesterase (ChE)
7β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and acetylcholinesterase .

HY-W012479R

H-D-Trp-OH (Standard) D-Tryptophan (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
H-D-Trp-OH (Standard) is the analytical standard of H-D-Trp-OH. This product is intended for research and analytical applications. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.

HY-N0876R

Arenobufagin (Standard)	Structural Classification Animals Steroids Source Classification	Reference Standards Apoptosis Autophagy PI3K Akt mTOR PARP Caspase Atg8/LC3
Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway .

HY-N0815R

Resibufogenin (Standard) Bufogenin (Standard); Recibufogenin (Standard)	Structural Classification Animals Steroids Source Classification	Reference Standards Others
Resibufogenin (Standard) is the analytical standard of Resibufogenin. This product is intended for research and analytical applications. Resibufogenin is an orally active anticancer agent. Resibufogenin can be extracted from toad venom. Resibufogenin blocks signaling pathways such as PI3K/Akt, NF-κB, AP-1, activates GSK-3β, and regulates cyclin D1. Resibufogenin can activate central neurons. Resibufogenin has anti-inflammatory activity. Resibufogenin has anti-tumor effects on a variety of tumors such as multiple myeloma, renal cancer, colorectal cancer, pancreatic cancer, and glioma .

HY-W142293

3-Methyl-3-buten-1-ol Methallylcarbinol	Structural Classification Natural Products Animals Source Classification	Drug Derivative
3-Methyl-3-buten-1-ol (Methallylcarbinol), a semiterpenoid alcohol, is an aggregation pheromone that can be found in the venom glands of the European hornet (Vespa crabro) and our-eyed spruce bark beetle .

HY-N7020

Cinobufaginol	Classification of Application Fields Animals Disease Research Fields Steroids Cancer Source Classification	Others
Cinobufaginol is a natural bufadienolide isolated from toad venom which has been widely used for centuries in China to treat different diseases, especially for cancer. Cinobufaginol potently inhibits the activity against human nasopharyngeal carcinoma cell lines with IC₅₀s of 803 μΜ and 1.270 μΜ for CNE-1 and CNE-2Z, respectively .

Tag:	SUMO (1) His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71455

	SVMP Protein, Crotalus adamanteus (His) Snake Venom metalloproteinase adamalysin-2; SVMP; EC 3.4.24.46; Adamalysin II; Proteinase II	Others	E. coli
	SVMP protein, while lacking significant hemorrhagic activity, functions by inactivating serpins through limited proteolysis of their reactive-site loops. SVMP Protein, Crotalus adamanteus (His) is the recombinant SVMP protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705701

	MIT1 Protein, Dendroaspis polylepis polylepis (His-SUMO) Toxin MIT1; MIT 1; Black mamba intestinal toxin 1; Black mamba Venom protein A	Others	E. coli

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HY-W012479S

H-D-Trp-OH-d5
H-D-Trp-OH-d₅ (D-Tryptophan-d₅) is the deuterium labeled H-D-Trp-OH. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.

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