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africana

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By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) Drug Derivative (3) TRP Channel (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7536

Voacangine	TRP Channel	Others
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-N12963

Quercetin-3,7-di-O-a-rhamnopyranoside Quercetin 3,7-dirhamnoside	Others	Others
Quercetin-3,7-di-O-α-rhamnopyranoside (Quercetin 3,7-dirhamnoside) is a flavonoid glycoside isolated from plants of the genus Randonia africana. The compound belongs to the group of flavonol glycosides identified in the aerial parts of Randonia africana .

HY-N3083

Phenylalanine betaine	Others	Others
Phenylalanine betaine is a betaine that can be isolated from Antiaris africana .

HY-N8351

Vobtusine NSC 180540; Vobtusin	Apoptosis	Others
Vobtusine is an alkaloid that has been found in V. africana leaves.

HY-N11532

Corynantheine	Others	Others
Corynantheine is a natural product that can be isolated from Pseudocinchona africana A. Chev. .

HY-N3639

Crassanine	Others	Others
Crassanine is a Alkaloids product that can be isolated from the herbs of Voacanga africana .

HY-W127497

Methyl 12-Methyltetradecanoate	Biochemical Assay Reagents	Others
Methyl 12-Methyltetradecanoate is a methylated fatty acid methyl ester that has been found in vermicompost of cow dung, papaya leaves, and cuticle wax of K. africana. It is a volatile compound in lipid-reducing granule tea. The levels of methyl 12-methylmyristate were reduced in T. cruzi treated with nifurtimox compared to untreated controls.

HY-N18718

*Prunus pygeum africana* extract**	Others	Others
Prunus pygeum africana extract is extracted from the bark of the African cherry tree. It can be used in health products.

HY-N18090

Voacamidine	Drug Derivative	Others
Voacamidine is an iboga-vobasinyl dimeric monoterpenoid indole alkaloid found in the root bark of Voacanga africana. Voacamidine undergoes cleavage in acid media to produce Voacangine (HY-N7536) .

HY-N18105

(-)-(S)-Celacinnine	Drug Derivative	Others
(-)-(S)-Celacinnine (compound 1) is a 13-membered monocyclic spermidine alkaloid with the (S)-configuration.(-)-(S)-Celacinnine can be found in Maytenus arbutifolia, Tripterygium wilfordii, Maytenus serrata, Maytenus heterophylla subsp. heterophylla, and Pleurostylia africana, all from the Celastraceae plant family .

HY-N12318

Sebiferenic acid	Others	Others
Sebiferenic acid is a secondary metabolite that can be isolated from Maprounea africana .

HY-167286

5-Methyldecane	Drug Derivative	Others
5-Methyldecane is a volatile component that can be extracted from Cordia Africana. 5-Methyldecane is also an pheromone that can be released by Platynereis dumerilii .

Methyl 12-Methyltetradecanoate	Biochemical Assay Reagents
Methyl 12-Methyltetradecanoate is a methylated fatty acid methyl ester that has been found in vermicompost of cow dung, papaya leaves, and cuticle wax of K. africana. It is a volatile compound in lipid-reducing granule tea. The levels of methyl 12-methylmyristate were reduced in T. cruzi treated with nifurtimox compared to untreated controls.

Voacangine	Alkaloids other families Classification of Application Fields Other Diseases Plants Disease Research Fields Indole Alkaloids Source Classification	TRP Channel
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

Quercetin-3,7-di-O-a-rhamnopyranoside Quercetin 3,7-dirhamnoside	Flavonoids other families Flavones Randonia africana Coss. Plants Source Classification	Others
Quercetin-3,7-di-O-α-rhamnopyranoside (Quercetin 3,7-dirhamnoside) is a flavonoid glycoside isolated from plants of the genus Randonia africana. The compound belongs to the group of flavonol glycosides identified in the aerial parts of Randonia africana .

Phenylalanine betaine	Antiaris toxicaria Lesch. Natural Products Plants Moraceae Source Classification	Others
Phenylalanine betaine is a betaine that can be isolated from Antiaris africana .

Corynantheine	Pseudocinchona africana A. Chev. Alkaloids other families Plants Indole Alkaloids Source Classification	Others
Corynantheine is a natural product that can be isolated from Pseudocinchona africana A. Chev. .

Crassanine	Apocynaceae Alkaloids Voacanga africana Stapf Plants Source Classification	Others
Crassanine is a Alkaloids product that can be isolated from the herbs of Voacanga africana .

*Prunus pygeum africana* extract**	Structural Classification Extract	Others
Prunus pygeum africana extract is extracted from the bark of the African cherry tree. It can be used in health products.

Voacamidine	Apocynaceae Structural Classification Alkaloids Voacanga africana Stapf Other Alkaloids Plants Source Classification	Drug Derivative
Voacamidine is an iboga-vobasinyl dimeric monoterpenoid indole alkaloid found in the root bark of Voacanga africana. Voacamidine undergoes cleavage in acid media to produce Voacangine (HY-N7536) .

(-)-(S)-Celacinnine	Structural Classification Alkaloids Other Alkaloids Celastraceae Gymnosporia arbutifolia (Hochst. ex A.Rich.) Loes. Plants Source Classification	Drug Derivative
(-)-(S)-Celacinnine (compound 1) is a 13-membered monocyclic spermidine alkaloid with the (S)-configuration.(-)-(S)-Celacinnine can be found in Maytenus arbutifolia, Tripterygium wilfordii, Maytenus serrata, Maytenus heterophylla subsp. heterophylla, and Pleurostylia africana, all from the Celastraceae plant family .

Sebiferenic acid	Triterpenes Structural Classification Terpenoids Triadica cochinchinensis Loureiro Euphorbiaceae Maprounea africana Müll.Arg. Plants Source Classification	Others
Sebiferenic acid is a secondary metabolite that can be isolated from Maprounea africana .

5-Methyldecane	Cordia africana Lam. Structural Classification Plants Boraginaceae Lipid Source Classification	Drug Derivative
5-Methyldecane is a volatile component that can be extracted from Cordia Africana. 5-Methyldecane is also an pheromone that can be released by Platynereis dumerilii .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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africana

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
Products