5878-43-3
Chemical Structure
Dihydrolysergic acid
- CAS No.: 5878-43-3
- Formula:C16H18N2O2
- Molecular Weight:270.33
IUPAC Name: (6aR,9R,10aS)-10a-methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylic acid
InChIKey: ORBSYPFBZQJNJE-MPKXVKKWSA-N
SMILES: CN1[C@@]2([H])[C@@](C[C@H](C1)C(O)=O)([H])C3=CC=CC4=C3C(C2)=CN4
Biological Activity: Dihydrolysergic acid is a fungal ergot alkaloid and also the dihydro analog of lysergic acid. Dihydrolysergic acid serves as a precursor for vasodilatory ergot alkaloid-derived drugs. Dihydrolysergic acid can be biosynthesized by expressing intron-free synthetic Claviceps africana cloA in an Neosartorya fumigata easM knockout strain[1][2].
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Dihydrolysergic acid | 99.89% | Dihydrolysergic acid is a fungal ergot alkaloid and also the dihydro analog of lysergic acid. Dihydrolysergic acid serves as a precursor for vasodilatory ergot alkaloid-derived drugs. Dihydrolysergic acid can be biosynthesized by expressing intron-free synthetic Claviceps africana cloA in an Neosartorya fumigata easM knockout strain. | ||||||||||||||||||||
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- [1]. Lee K, et al. Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs. Tetrahedron. 2015 Sep 02;71(35):5897-5905. [Content Brief]
- [2]. Arnold SL, et al. Biosynthesis of the Pharmaceutically Important Fungal Ergot Alkaloid Dihydrolysergic Acid Requires a Specialized Allele of . Applied and environmental microbiology. 2017 Jul 15;83(14):e00805-17. [Content Brief]
Keywords
