18 Results for "

anti-CD40

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "anti-CD40" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-131968
CAS No.: 1771691-34-9
Purity:  99.92%
BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 value of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium .
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Cat. No.: HY-153345
CAS No.: 2345733-40-4
Purity:  99.67%
Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br is an Drug-linker conjugates for ADC that can be used as a reaction reagent for the synthesis of anti-CD40 antibody agent conjugates (ADCs) .
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Cat. No.: HY-152121
CAS No.: 2345732-89-8
Purity:  95.21%
Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal is a glucocorticoid receptor agonist. Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal can be used in anti-CD40 antibody agent conjugate (ADC). Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal can be used for the research of inflammation and immune regulation .
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Cat. No.: HY-P99315
CAS No.: 220651-94-5
Synonyms: BG 9588; anti-Human CD40L Recombinant antibody; Hu5c8

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1κ monoclonal antibody. By binding to CD40L, Ruplizumab blocks its interaction with the CD40 receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P99167
CAS No.: 903512-50-5
Synonyms: HCD122

Target:  

TNF Receptor

Research Areas:  

Cancer

Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research .
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Cat. No.: HY-P990111

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

BMS-986325 (anti-CD40) is a CD40 inhibitor, and can be used for primary Sj gren's syndrome research .
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Cat. No.: HY-P990860

Target:  

TNF Receptor

Research Areas:  

Cancer

Anti-CD40 Antibody (G28.5) is a kind of mouse IgG1 κ chimeric agonistic antibody, targeting to human CD40. Anti-CD40 Antibody (G28.5) can activate CD40 signaling and promote anti-tumor T cell responses. Anti-CD40 Antibody (G28.5) can be used for the research of cancer, such as endometrial cancer .
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Cat. No.: HY-49382
CAS No.: 2166375-81-9
Research Areas:  

Others

Fluocinolone acetonide 3-benzylaniline (Precursor Example 1) is a glucocorticoid receptor agonist-linker conjugate, which can be used for the synthesis of anti-CD40 antibody-drug conjugates (ADCs) .
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Cat. No.: HY-P99015
CAS No.: 880486-59-9

Target:  

TNF Receptor

Research Areas:  

Cancer

Dacetuzumab (SGN-40) is a humanized IgG1, anti-CD40 monoclonal antibody with anti-lymphoma activity. Dacetuzumab kills tumor cells via immune effector functions (antibody-dependent cellular cytotoxicity and phagocytosis [ADCC/ADCP]). Dacetuzumab ((SGN-40) can be used for multiple myeloma research .
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Cat. No.: HY-P99257
CAS No.: 1453067-91-8
Synonyms: ASKP 1240

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (Kd: 0.24 nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection .
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Cat. No.: HY-P990726
CAS No.: 2765071-95-0
Synonyms: KPL-404

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Abiprubart is an anti-CD40 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P991513

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

BI-655064, a humanised anti-CD40 antibody with has fragment crystallisable (Fc) regions with two mutations that prevent Fc-mediated antibody-dependent or complement-mediated cellular cytotoxicity and platelet activation. BI-655064 can be used for the study of autoimmune disease, such as lupus nephritis and rheumatoid arthritis (RA) .
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Cat. No.: HY-148459
CAS No.: 2101204-23-1
Research Areas:  

Cancer

ATAC21, a linker-immune-stimulatory compound that can be formed by conjugating a noncleavable maleimide-PEG4 linker containing a succinimide group with an immune- stimulatory compound. ATAC21 can be combined with SBT-040 (anti-CD40 antibody) to form a conjugate .
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Cat. No.: HY-P99640
CAS No.: 2226292-20-0
Synonyms: ABBV-927

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Giloralimab (ABBV-927) is a potent antiCD40 agonistic monoclonal antibody. Giloralimab has the potential for the research of cancer .
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Cat. No.: HY-P99663
CAS No.: 2568264-76-4
Synonyms: AMG-994

Target:  

TNF Receptor

Research Areas:  

Cancer

Inezetamab is a bispecific anti-CD40 and anti-MSLN IgG1 monoclonal antibody .
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Cat. No.: HY-400878
CAS No.: 2345732-83-2
Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal, a glucocorticoid receptor agonist, is a drug-linker conjugate for ADC. Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal can be used to synthesize the anti-CD40 antibody agent conjugates (WO2019106608A1; example 9) .
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Cat. No.: HY-171590
CAS No.: 2810809-10-8
Research Areas:  

Inflammation/Immunology

SIK2-IN-3 is an orally active SIK1/2 selective inhibitor (IC50: 0.128/0.084 μM). SIK2-IN-3 inhibits CRTC3 phosphorylation and myeloid cell pro-inflammatory cytokine production. SIK2-IN-3 ameliorates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model .
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Cat. No.: HY-P991555

Target:  

TNF Receptor Apoptosis

Research Areas:  

Cancer

XmAb5485 is an Fc-engineered humanized anti-CD40 monoclonal antibody with high affinity to Fc-γ receptors. XmAb5485 induces potent antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) against tumor cells. XmAb5485 inhibits proliferation and induces apoptosis of tumor cells. XmAb5485 shows highly cytotoxic against lymphoma, leukemia and multiple myeloma cell lines as well as primary cancer cells .
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