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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
68 Results for "
carboline
" in MedChemExpress (MCE) Product Catalog:
Products (68)
68 Results for "carboline" in MCE Product Catalog:
Cat. No.: HY-W094994
CAS No.: 244-76-8
Synonyms: alpha-carboline
Target:
Research Areas:
α-carboline (alpha-Carboline) is a promising scaffold compound for medicinal chemistry. α-carboline natural products and their derivatives possess diverse bioactivities .
Cat. No.: HY-W006474
CAS No.: 244-69-9
Synonyms: 5H-Pyrido[4,3-b]indole
Target:
γ-Carboline is a skeleton and antiviral agent. γ-Carboline shows anti-BVDV activity, with an EC50 of 2.0 μM. γ-Carboline derivatives show anti-BVDV, antibacterial, antifungal, antitumor activity .
2
2 Cited Publications
Synonyms: Keramamine A hydrochloride
1
Cat. No.: HY-W008566
CAS No.: 244-63-3
Synonyms: Norharman; β-carboline
Category:
Alkaloids Simaroubaceae Other Diseases Pyridine Alkaloids Plants Disease Research Fields Indole Alkaloids
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Cat. No.: HY-20696
CAS No.: 16502-01-5
Synonyms: Tryptoline
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Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 µM .
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Research Areas:
Ethyl β-carboline-3-carboxylate (fl-CCE) is a ligand and short-acting antagonist of benzodiazepine receptors. Ethyl β-carboline-3-carboxylate did not affect cerebellar cGMP levels when used alone, but when taken together with Diazepam, it significantly inhibited the cGMP levels that were upregulated by Diazepam .
Cat. No.: HY-N3711
CAS No.: 26585-13-7
Category:
Alkaloids Monophenols Zygophyllaceae Peganum harmala Linn. Other Diseases Pyridine Alkaloids Phenols Plants Disease Research Fields
Target:
Synonyms: Keramamine A
Cat. No.: HY-W049881
CAS No.: 2521-07-5
Target:
Research Areas:
9-Methyl-β-carboline is a monoamine oxidase inhibitor and dopaminergic modulator, with an IC50 of 1 μM against human MAO-A and an IC50 of 15.5 μM against human MAO-B. 9-Methyl-β-carboline possesses cognitive enhancement potential and can cross the blood-brain barrier. 9-Methyl-β-carboline increases dopamine levels by inhibiting monoamine oxidase activity and microglial proliferation. 9-Methyl-β-carboline activates PKA/PKC and mitochondrial respiratory chain complex I, promotes neurotrophic factor expression and reduces α-synuclein (α-synuclein) levels, thereby reversing neurotoxin-induced dopaminergic neuron damage. 9-Methyl-β-carboline also regulates the PI3K pathway and exerts an anti-proliferative effect on astrocytes. 9-Methyl-β-carboline is widely used in Parkinson's disease-related studies .
Cat. No.: HY-W130965
CAS No.: 20127-63-3
Target:
Cat. No.: HY-N10450
CAS No.: 72755-19-2
Synonyms: 1-Ethoxycarbonyl-β-carboline
Target:
ZDLD20, a β-carboline, is orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 6.51 μM. ZDLD20 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD20 exhibits potent anticancer activity .
Synonyms: 2-Amino-α-carboline; AαC
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Research Areas:
AalphaC (AαC) is a potential carcinogen with carcinogenic activity. AalphaC is an important biomarker in tobacco smoke and is associated with tobacco smoke exposure. Urinary concentrations of AalphaC are significantly higher in dedicated smokers than in non-smokers, indicating its importance in monitoring tobacco exposure. AalphaC levels increase significantly with increasing serum nicotine levels, indicating its close relationship with tobacco use. In addition, consuming high-temperature cooked beef significantly increases the amount of AalphaC in urine, while consuming vegetables is associated with a decrease in AalphaC concentrations. Smoking half a pack of cigarettes is associated with a significant increase in the amount of AalphaC, which further confirms the biological activity of AalphaC and its association with dietary habits .
Cat. No.: HY-174156
CAS No.: 3092616-03-7
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Research Areas:
Y2641, a etrahydro-β-carboline derivative, is an orally active dual RANKL/TNF-α inhibitor with Kd values of 3.984 μM and 18.59 μM for RANKL and TNF-α, respectively. Y2641 inhibits RANKL-induced osteoclastogenic and has anti-inflammatory and cartilage destruction. Y2641 can be used for study of osteoarthritis .
Cat. No.: HY-W060074
CAS No.: 50892-83-6
Category:
Infection Alkaloids Microorganisms Pyridine Alkaloids Disease Research Fields Indole Alkaloids
Target:
Cat. No.: HY-N11016
CAS No.: 55854-60-9
Category:
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
