2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Tetrahydro-β-carboline

Tetrahydro-β-carboline  (Synonyms: Tryptoline)

Cat. No.: HY-20696 Purity: 97.14%
COA Handling Instructions

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Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 µM.

For research use only. We do not sell to patients.

Tetrahydro-β-carboline Chemical Structure

Tetrahydro-β-carboline Chemical Structure

CAS No. : 16502-01-5

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Tetrahydro-β-carboline Related Antibodies

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Description

Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 µM[1].

IC50 & Target[1]

serotonin

6.1 μM (Ki)

In Vivo

Tetrahydro-β-carboline (20 µg; i.c.v.) increases the serotonin levels in the same part of the brain in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 180-200g female Sprague-Dawley rats[1]
Dosage: 20 µg
Administration: Intraventricular injection
Result: Increased of serotonin levels in the same part of the brain whereas the monoamine oxidase activity was not altered.
Molecular Weight

172.23

Formula

C11H12N2
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

C1(NC2=C3CCNC2)=C3C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (580.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8062 mL 29.0309 mL 58.0619 mL
5 mM 1.1612 mL 5.8062 mL 11.6124 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.54%

COA (251 KB) HNMR (120 KB) LCMS (120 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.8062 mL 29.0309 mL 58.0619 mL 145.1547 mL
5 mM 1.1612 mL 5.8062 mL 11.6124 mL 29.0309 mL
10 mM 0.5806 mL 2.9031 mL 5.8062 mL 14.5155 mL
15 mM 0.3871 mL 1.9354 mL 3.8708 mL 9.6770 mL
20 mM 0.2903 mL 1.4515 mL 2.9031 mL 7.2577 mL
25 mM 0.2322 mL 1.1612 mL 2.3225 mL 5.8062 mL
30 mM 0.1935 mL 0.9677 mL 1.9354 mL 4.8385 mL
40 mM 0.1452 mL 0.7258 mL 1.4515 mL 3.6289 mL
50 mM 0.1161 mL 0.5806 mL 1.1612 mL 2.9031 mL
60 mM 0.0968 mL 0.4838 mL 0.9677 mL 2.4192 mL
80 mM 0.0726 mL 0.3629 mL 0.7258 mL 1.8144 mL
100 mM 0.0581 mL 0.2903 mL 0.5806 mL 1.4515 mL
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Tetrahydro-β-carboline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrahydro-β-carboline16502-01-5Tryptoline5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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